GREMLIN Database
DUF4378 - Domain of unknown function (DUF4378)
PFAM: PF14309 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 149 (148)
Sequences: 1214 (915)
Seq/√Len: 75.2
META: 0.086

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_Y38_F5.8281.00
38_F42_E3.1621.00
75_Y78_P2.9301.00
2_F5_V2.8861.00
38_F54_K2.7271.00
4_Y42_E2.3571.00
2_F102_W2.3231.00
42_E53_R2.2211.00
58_D124_W2.1421.00
110_L118_L2.1371.00
62_E149_E2.1321.00
82_S85_P2.0481.00
118_L122_G1.9061.00
60_V129_E1.8661.00
140_R143_L1.8351.00
22_L29_S1.8311.00
76_P81_S1.8301.00
79_W83_V1.8271.00
5_V123_G1.7981.00
5_V101_V1.7721.00
62_E117_D1.7561.00
146_L149_E1.6981.00
111_D118_L1.6541.00
75_Y79_W1.5990.99
37_L41_L1.5570.99
73_F77_P1.5500.99
79_W84_K1.5370.99
79_W82_S1.5320.99
111_D114_V1.5280.99
55_L117_D1.4880.99
56_L105_I1.4800.99
8_I60_V1.4560.99
4_Y57_F1.4510.99
19_S23_L1.4040.99
114_V118_L1.3920.99
23_L26_W1.3850.99
80_V84_K1.3530.98
57_F61_N1.3310.98
26_W29_S1.3240.98
73_F79_W1.2730.97
97_L139_E1.2710.97
74_S77_P1.2580.97
80_V83_V1.2580.97
112_E136_L1.2510.97
81_S85_P1.2460.97
48_E147_V1.2440.97
59_C105_I1.2430.97
32_P139_E1.2350.97
135_G139_E1.2120.96
47_L64_L1.2090.96
104_E108_W1.2020.96
38_F53_R1.2010.96
77_P82_S1.2010.96
44_K50_R1.1950.96
9_L113_L1.1690.96
41_L107_R1.1520.95
106_S135_G1.1460.95
3_S8_I1.1410.95
74_S79_W1.1310.95
63_I104_E1.1290.95
113_L118_L1.1080.94
54_K104_E1.0970.94
13_G61_N1.0910.94
141_L145_D1.0680.93
77_P80_V1.0640.93
136_L143_L1.0550.93
12_S141_L1.0390.92
73_F76_P1.0290.92
113_L133_E1.0270.92
69_E114_V1.0270.92
55_L123_G1.0250.91
122_G127_L1.0210.91
114_V119_S1.0190.91
36_S137_E1.0080.91
97_L106_S1.0020.91
10_S15_L0.9930.90
60_V141_L0.9880.90
94_G103_K0.9760.89
59_C115_D0.9750.89
42_E45_Y0.9710.89
50_R53_R0.9660.89
26_W105_I0.9610.89
60_V115_D0.9590.89
121_G142_I0.9580.88
99_E103_K0.9580.88
119_S122_G0.9460.88
96_K125_L0.9440.88
6_K59_C0.9440.88
50_R57_F0.9440.88
5_V11_A0.9300.87
45_Y130_E0.9250.87
45_Y56_L0.9230.87
116_K135_G0.9140.86
6_K53_R0.9130.86
80_V85_P0.9120.86
42_E57_F0.9110.86
53_R109_L0.9090.86
144_D149_E0.9080.86
16_G138_I0.8980.85
138_I147_V0.8970.85
86_R89_P0.8960.85
90_P114_V0.8960.85
94_G97_L0.8900.84
113_L117_D0.8790.84
131_I135_G0.8740.83
55_L66_E0.8730.83
11_A58_D0.8560.82
13_G32_P0.8560.82
61_N65_L0.8510.82
42_E54_K0.8470.81
36_S130_E0.8360.81
48_E106_S0.8330.80
5_V65_L0.8330.80
26_W30_D0.8320.80
22_L27_H0.8270.80
78_P84_K0.8190.79
38_F41_L0.8190.79
40_E61_N0.8180.79
52_D98_L0.8070.78
6_K12_S0.8060.78
72_S77_P0.7980.77
74_S84_K0.7940.77
128_R145_D0.7920.77
82_S86_R0.7920.77
8_I40_E0.7870.76
109_L137_E0.7730.75
7_D52_D0.7720.75
27_H30_D0.7700.75
102_W106_S0.7650.74
84_K87_I0.7630.74
97_L111_D0.7630.74
110_L113_L0.7610.74
67_I104_E0.7480.73
67_I144_D0.7450.72
73_F81_S0.7430.72
25_R29_S0.7410.72
140_R149_E0.7400.72
63_I108_W0.7390.72
83_V86_R0.7340.71
74_S78_P0.7330.71
115_D118_L0.7300.71
52_D130_E0.7300.71
6_K10_S0.7290.71
117_D132_E0.7290.71
33_L61_N0.7250.70
26_W31_S0.7240.70
58_D61_N0.7190.70
54_K137_E0.7110.69
21_S134_I0.7030.68
74_S136_L0.6880.66
4_Y112_E0.6870.66
35_P66_E0.6830.66
6_K11_A0.6820.66
37_L98_L0.6810.66
124_W136_L0.6800.65
72_S82_S0.6790.65
143_L146_L0.6680.64
39_D113_L0.6630.63
7_D60_V0.6620.63
59_C108_W0.6620.63
31_S37_L0.6570.63
59_C102_W0.6430.61
101_V109_L0.6430.61
114_V121_G0.6420.61
54_K122_G0.6370.60
12_S143_L0.6370.60
13_G94_G0.6310.60
94_G98_L0.6220.59
11_A23_L0.6170.58
24_A27_H0.6160.58
60_V90_P0.6160.58
8_I52_D0.6150.58
18_D29_S0.6130.57
50_R54_K0.6130.57
41_L50_R0.6130.57
13_G97_L0.6120.57
66_E120_G0.6110.57
136_L144_D0.6080.57
25_R31_S0.6040.56
33_L40_E0.6000.56
59_C116_K0.5950.55
32_P55_L0.5940.55
37_L129_E0.5940.55
34_D51_S0.5830.54
32_P59_C0.5820.54
116_K130_E0.5810.54
79_W85_P0.5780.53
34_D66_E0.5720.52
12_S64_L0.5670.52
109_L148_E0.5670.52
120_G143_L0.5640.51
78_P81_S0.5640.51
122_G132_E0.5610.51
93_S105_I0.5610.51
103_K142_I0.5610.51
54_K89_P0.5550.50
43_K48_E0.5520.50
46_S99_E0.5490.49
10_S143_L0.5460.49
23_L146_L0.5460.49
84_K88_R0.5390.48
65_L68_L0.5390.48
8_I15_L0.5360.48
89_P93_S0.5360.48
55_L128_R0.5320.47
128_R132_E0.5310.47
72_S78_P0.5310.47
81_S84_K0.5310.47
57_F140_R0.5250.46
93_S99_E0.5250.46
27_H149_E0.5240.46
84_K141_L0.5180.46
30_D96_K0.5140.45
3_S103_K0.5110.45
140_R144_D0.5110.45
22_L68_L0.5090.44
37_L137_E0.5090.44
46_S148_E0.5070.44
50_R83_V0.5060.44
53_R139_E0.5050.44
7_D14_L0.5020.44
102_W120_G0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2lseA 1 0.5101 7.5 0.928 Contact Map
2dmeA 1 0.3893 5.1 0.933 Contact Map
4kk0A 2 0.8591 4.5 0.935 Contact Map
1ldjA 1 0.3423 3.3 0.939 Contact Map
1q1vA 1 0.3557 3.1 0.94 Contact Map
2vxoA 2 0.4564 3.1 0.94 Contact Map
2btmA 2 0.9128 2.9 0.941 Contact Map
3upsA 2 0.3624 2.6 0.942 Contact Map
3p9aA 4 0.5302 2.4 0.944 Contact Map
1fc6A 1 0.3624 2.3 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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