GREMLIN Database
DnaJ-X - X-domain of DnaJ-containing
PFAM: PF14308 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 208 (196)
Sequences: 715 (485)
Seq/√Len: 34.6
META: 0.266

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_G185_G5.1741.00
9_A162_K4.6281.00
16_L180_A4.0581.00
63_A182_K3.9171.00
17_S21_E3.4911.00
35_A184_L3.1641.00
51_L152_I3.0781.00
164_L181_L2.8431.00
169_V174_R2.8081.00
8_L159_V2.7541.00
16_L181_L2.7261.00
57_Y87_H2.6911.00
48_G145_W2.6521.00
15_R38_E2.5891.00
5_V158_E2.5761.00
33_E36_R2.5111.00
87_H153_E2.4511.00
55_I156_L2.4491.00
39_A187_I2.3750.99
1_Q155_T2.3270.99
27_V30_A2.1960.99
40_E43_K2.1410.99
2_K6_E2.0300.98
1_Q5_V2.0160.98
42_L59_Y1.9840.98
39_A188_F1.9360.98
67_L178_A1.9260.98
8_L59_Y1.8670.97
4_R155_T1.8190.97
29_E33_E1.7610.96
82_V85_K1.7330.96
67_L175_K1.7270.95
163_V177_R1.7110.95
51_L59_Y1.6880.95
66_F188_F1.6650.94
170_S173_K1.6440.94
71_K76_G1.6260.94
42_L187_I1.5980.93
13_K16_L1.5910.93
6_E10_E1.5860.93
6_E9_A1.5330.92
5_V155_T1.5060.91
31_F35_A1.4660.90
14_D17_S1.4520.89
127_E130_A1.4480.89
92_T95_T1.4400.89
166_D174_R1.4340.89
55_I86_G1.4250.88
56_G177_R1.4210.88
170_S176_L1.3760.86
20_V173_K1.3660.86
53_H163_V1.3630.86
177_R185_G1.3590.86
3_E7_K1.3510.85
60_V186_E1.3390.85
42_L51_L1.3260.84
48_G149_K1.3160.84
21_E173_K1.3120.84
19_Y28_T1.2590.81
109_M132_L1.2590.81
7_K47_F1.2510.81
31_F145_W1.1960.77
39_A65_Q1.1960.77
141_L160_C1.1820.77
110_A114_E1.1700.76
143_A147_G1.1690.76
75_V78_F1.1660.76
31_F52_L1.1570.75
1_Q4_R1.1300.73
112_A116_G1.1260.73
49_V53_H1.1250.73
195_E198_E1.1210.73
92_T154_S1.1190.73
151_D155_T1.0740.69
193_R197_E1.0670.69
31_F160_C1.0390.67
95_T99_A1.0340.66
128_E131_E1.0230.66
110_A113_E1.0220.66
36_R190_K1.0140.65
13_K163_V1.0090.64
39_A132_L1.0090.64
9_A13_K1.0060.64
9_A83_K1.0060.64
32_R186_E0.9980.64
24_K176_L0.9960.63
87_H93_V0.9810.62
4_R56_G0.9710.61
148_N152_I0.9660.61
137_T140_I0.9620.61
46_S133_E0.9600.61
36_R170_S0.9580.60
58_V153_E0.9490.60
18_P22_G0.9480.60
17_S20_V0.9390.59
89_V96_A0.9290.58
159_V163_V0.9230.58
10_E14_D0.9210.57
5_V149_K0.9170.57
65_Q80_S0.9110.57
64_A98_S0.9100.56
54_T188_F0.9100.56
94_S146_K0.9090.56
153_E181_L0.9090.56
20_V27_V0.9080.56
16_L42_L0.9060.56
5_V9_A0.9040.56
179_K183_I0.9030.56
18_P21_E0.8950.55
82_V86_G0.8950.55
156_L160_C0.8670.53
61_R94_S0.8660.53
90_K106_M0.8600.52
33_E60_V0.8570.52
79_F184_L0.8550.52
194_D197_E0.8410.51
78_F82_V0.8230.49
64_A182_K0.8210.49
58_V105_T0.8210.49
152_I200_E0.8180.49
23_D26_G0.8140.48
43_K52_L0.8080.48
193_R196_E0.8070.48
145_W149_K0.8060.48
67_L155_T0.8060.48
11_K15_R0.8030.47
43_K149_K0.8020.47
52_L180_A0.7930.46
62_K164_L0.7920.46
190_K195_E0.7910.46
103_Q148_N0.7900.46
186_E189_Q0.7900.46
8_L151_D0.7850.46
152_I180_A0.7850.46
103_Q107_E0.7780.45
3_E155_T0.7750.45
8_L51_L0.7720.45
66_F178_A0.7700.45
50_E74_G0.7650.44
51_L155_T0.7620.44
6_E162_K0.7610.44
162_K171_K0.7550.43
92_T106_M0.7520.43
133_E143_A0.7520.43
122_E188_F0.7510.43
82_V156_L0.7510.43
130_A133_E0.7480.43
4_R177_R0.7450.42
33_E37_L0.7420.42
116_G121_G0.7370.42
60_V162_K0.7350.42
133_E147_G0.7280.41
131_E169_V0.7260.41
21_E54_T0.7230.41
104_Q174_R0.7230.41
49_V197_E0.7220.41
83_K86_G0.7210.40
54_T141_L0.7190.40
108_E116_G0.7160.40
19_Y93_V0.7150.40
111_K115_K0.7140.40
2_K143_A0.7100.40
39_A191_A0.7050.39
70_Q153_E0.7040.39
105_T152_I0.7040.39
166_D177_R0.7020.39
69_S158_E0.7020.39
14_D96_A0.7000.39
136_V140_I0.6970.39
173_K176_L0.6940.38
86_G145_W0.6900.38
113_E116_G0.6890.38
10_E22_G0.6880.38
43_K49_V0.6870.38
4_R180_A0.6820.37
11_K63_A0.6780.37
26_G169_V0.6770.37
59_Y164_L0.6760.37
166_D170_S0.6760.37
42_L164_L0.6720.37
113_E162_K0.6680.36
88_V150_F0.6680.36
168_S183_I0.6660.36
16_L164_L0.6650.36
2_K169_V0.6630.36
68_G76_G0.6600.36
137_T153_E0.6580.35
126_E130_A0.6560.35
107_E110_A0.6540.35
10_E13_K0.6530.35
51_L148_N0.6520.35
58_V87_H0.6450.34
171_K180_A0.6440.34
51_L54_T0.6430.34
62_K159_V0.6410.34
68_G189_Q0.6380.34
42_L148_N0.6340.34
16_L36_R0.6330.33
169_V175_K0.6320.33
106_M136_V0.6270.33
53_H164_L0.6270.33
47_F188_F0.6270.33
145_W148_N0.6250.33
26_G176_L0.6240.33
13_K177_R0.6210.33
191_A200_E0.6200.32
81_R111_K0.6120.32
94_S99_A0.6110.32
113_E129_L0.6080.32
98_S106_M0.6050.31
14_D19_Y0.6010.31
144_L148_N0.5990.31
9_A196_E0.5990.31
37_L154_S0.5980.31
8_L61_R0.5970.31
62_K149_K0.5940.31
8_L11_K0.5920.30
17_S141_L0.5910.30
46_S66_F0.5890.30
22_G151_D0.5880.30
43_K151_D0.5880.30
112_A115_K0.5860.30
101_D154_S0.5860.30
42_L144_L0.5850.30
31_F62_K0.5830.30
147_G151_D0.5800.30
84_D90_K0.5790.30
182_K195_E0.5760.29
60_V171_K0.5760.29
69_S81_R0.5740.29
179_K188_F0.5740.29
157_R161_D0.5730.29
98_S102_A0.5710.29
111_K114_E0.5680.29
133_E136_V0.5670.29
17_S27_V0.5630.28
175_K180_A0.5630.28
42_L153_E0.5630.28
32_R36_R0.5630.28
23_D27_V0.5610.28
22_G26_G0.5600.28
160_C181_L0.5590.28
42_L62_K0.5590.28
77_G147_G0.5580.28
22_G179_K0.5580.28
140_I144_L0.5570.28
168_S174_R0.5550.28
4_R116_G0.5520.28
73_L171_K0.5520.28
148_N159_V0.5510.28
149_K188_F0.5500.27
55_I102_A0.5480.27
40_E135_E0.5470.27
95_T110_A0.5470.27
39_A43_K0.5470.27
47_F156_L0.5470.27
143_A157_R0.5450.27
166_D169_V0.5440.27
1_Q158_E0.5430.27
1_Q151_D0.5420.27
19_Y179_K0.5410.27
46_S57_Y0.5370.27
149_K153_E0.5370.27
22_G25_G0.5310.26
89_V158_E0.5310.26
12_L16_L0.5290.26
39_A177_R0.5270.26
131_E134_E0.5270.26
169_V181_L0.5260.26
8_L46_S0.5260.26
96_A105_T0.5250.26
15_R35_A0.5240.26
76_G81_R0.5230.26
63_A89_V0.5230.26
103_Q147_G0.5230.26
57_Y69_S0.5220.26
105_T112_A0.5210.26
86_G141_L0.5200.25
81_R86_G0.5200.25
93_V97_S0.5160.25
32_R183_I0.5150.25
13_K166_D0.5140.25
114_E141_L0.5120.25
60_V185_G0.5110.25
98_S142_E0.5100.25
69_S78_F0.5100.25
21_E30_A0.5090.25
90_K162_K0.5090.25
103_Q106_M0.5050.25
162_K166_D0.5030.24
50_E132_L0.5030.24
54_T160_C0.5030.24
75_V116_G0.5020.24
18_P30_A0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k62A 1 0.25 10.7 0.949 Contact Map
3msvA 2 0.4712 5 0.956 Contact Map
2wscG 1 0.3029 5 0.956 Contact Map
1yviA 1 0.6635 3.4 0.96 Contact Map
4g78A 1 0.649 3.2 0.96 Contact Map
2rawB 1 0.2692 2.9 0.961 Contact Map
2qzgA 2 0.2981 2.7 0.962 Contact Map
3a8yC 1 0.1202 2.7 0.962 Contact Map
1nfnA 1 0.2885 2.5 0.962 Contact Map
2zg6A 2 0.3173 2.2 0.963 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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