GREMLIN Database
DUF4377 - Domain of unknown function (DUF4377)
PFAM: PF14302 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (75)
Sequences: 2580 (2000)
Seq/√Len: 231.0
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_R65_I3.0581.00
9_C17_C2.4501.00
51_K68_V2.3611.00
49_R71_E2.3191.00
6_T18_L2.2441.00
8_D16_K2.2191.00
53_T68_V2.1541.00
44_Y75_K1.9051.00
69_L72_V1.8551.00
55_V58_P1.7801.00
59_P62_A1.6911.00
52_R67_Y1.6911.00
31_F67_Y1.6831.00
2_V20_V1.6701.00
47_V74_S1.6421.00
36_E68_V1.6311.00
36_E66_R1.5641.00
40_Y46_Y1.5521.00
2_V48_L1.5441.00
6_T16_K1.4581.00
53_T66_R1.4191.00
1_E21_R1.3481.00
16_K42_P1.3301.00
47_V73_V1.3021.00
22_E29_Q1.2751.00
55_V66_R1.2631.00
21_R28_W1.2591.00
4_P45_E1.2051.00
41_E75_K1.1981.00
5_E42_P1.1901.00
3_A45_E1.1741.00
51_K70_V1.1711.00
7_V19_Q1.1651.00
41_E44_Y1.1181.00
38_F46_Y1.1161.00
22_E52_R1.1021.00
23_S26_G1.0991.00
49_R70_V1.0861.00
54_K65_I1.0691.00
21_R45_E1.0641.00
3_A19_Q1.0411.00
1_E45_E1.0161.00
37_G69_L0.9821.00
19_Q30_L0.9791.00
1_E24_P0.9781.00
33_D63_S0.9261.00
10_V14_P0.9151.00
5_E19_Q0.8960.99
12_V61_D0.8690.99
58_P62_A0.8580.99
12_V15_Q0.8470.99
60_A63_S0.8400.99
35_I69_L0.8400.99
18_L34_E0.8360.99
1_E47_V0.8290.99
20_V31_F0.8290.99
54_K64_S0.8140.99
1_E23_S0.8120.99
31_F34_E0.7930.99
28_W45_E0.7790.98
11_G32_Y0.7760.98
48_L69_L0.7660.98
46_Y72_V0.7610.98
6_T34_E0.7590.98
26_G29_Q0.7440.98
72_V75_K0.7270.98
3_A21_R0.7150.97
38_F69_L0.7120.97
21_R27_E0.7070.97
21_R26_G0.7040.97
11_G14_P0.6960.97
10_V61_D0.6940.97
15_Q32_Y0.6910.97
8_D14_P0.6850.97
32_Y59_P0.6710.96
5_E47_V0.6610.96
40_Y45_E0.6600.96
33_D67_Y0.6400.95
22_E26_G0.6370.95
11_G15_Q0.6360.95
54_K58_P0.6350.95
1_E25_D0.6290.95
10_V13_G0.6280.95
19_Q28_W0.6240.94
60_A64_S0.6170.94
4_P42_P0.6130.94
51_K66_R0.6040.93
46_Y69_L0.5980.93
55_V64_S0.5960.93
3_A6_T0.5850.92
58_P61_D0.5720.91
55_V59_P0.5690.91
27_E57_N0.5680.91
21_R47_V0.5640.91
13_G16_K0.5540.90
46_Y75_K0.5530.90
49_R73_V0.5490.90
50_V67_Y0.5490.90
55_V62_A0.5440.89
71_E74_S0.5430.89
2_V46_Y0.5420.89
20_V29_Q0.5290.88
34_E66_R0.5270.88
71_E75_K0.5260.88
38_F41_E0.5120.86
70_V74_S0.5100.86
7_V30_L0.5070.86
39_T71_E0.5050.85
58_P64_S0.5020.85
61_D64_S0.5020.85
1_E22_E0.5010.85
57_N64_S0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cjlA 2 0.4 6.4 0.887 Contact Map
1cx1A 1 0.9867 3.2 0.902 Contact Map
4hsaC 1 0.92 3.1 0.903 Contact Map
4kw3A 1 0.4667 2.5 0.908 Contact Map
2c4xA 1 0.52 2 0.913 Contact Map
4gl2A 1 0.4133 1.8 0.915 Contact Map
3e9vA 1 0.3333 1.7 0.916 Contact Map
2qqpA 9 0.8 1.7 0.916 Contact Map
4mgqA 1 0.9867 1.6 0.917 Contact Map
1pc6A 2 0.7733 1.6 0.917 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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