GREMLIN Database
DUF4376 - Domain of unknown function (DUF4376)
PFAM: PF14301 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (99)
Sequences: 3306 (2795)
Seq/√Len: 280.9
META: 0.838

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_A11_A3.8901.00
62_T65_Q3.6711.00
26_D29_S2.9651.00
96_T99_E2.5541.00
83_A87_L2.2481.00
7_A10_R2.1821.00
87_L90_A2.1011.00
15_G25_T1.9501.00
39_A74_A1.9471.00
87_L94_A1.9461.00
53_T57_T1.9381.00
83_A86_A1.9061.00
52_K58_F1.7871.00
76_H80_C1.6381.00
52_K84_E1.5741.00
78_Q82_A1.5731.00
5_K88_K1.5611.00
34_T38_L1.5551.00
53_T59_V1.5411.00
6_A10_R1.5001.00
52_K85_R1.4621.00
17_T22_T1.4601.00
50_T60_T1.4151.00
24_D29_S1.3201.00
85_R89_A1.3161.00
36_A51_W1.3061.00
23_F69_L1.2691.00
52_K81_F1.2351.00
63_A67_I1.2351.00
97_I100_V1.2281.00
41_Q67_I1.2231.00
84_E88_K1.2091.00
4_I91_I1.2081.00
44_P47_G1.2071.00
11_A14_G1.2061.00
37_V41_Q1.2011.00
25_T73_V1.1951.00
16_F76_H1.1711.00
37_V67_I1.1571.00
42_A71_A1.1231.00
94_A100_V1.1141.00
4_I84_E1.0771.00
5_K9_D1.0721.00
37_V70_A1.0601.00
30_Q77_V1.0581.00
27_R31_A1.0531.00
24_D56_N1.0531.00
24_D54_A1.0471.00
21_K53_T1.0411.00
11_A80_C1.0371.00
79_A83_A1.0301.00
21_K57_T1.0301.00
75_A79_A1.0021.00
40_A66_L0.9991.00
40_A67_I0.9981.00
9_D12_E0.9941.00
15_G76_H0.9871.00
18_V69_L0.9711.00
9_D13_T0.9581.00
61_L65_Q0.9491.00
64_A67_I0.9431.00
95_T99_E0.9281.00
43_A47_G0.9121.00
68_A72_A0.9101.00
12_E80_C0.9051.00
43_A46_A0.9031.00
12_E32_R0.8981.00
16_F73_V0.8941.00
8_R84_E0.8801.00
40_A63_A0.8721.00
4_I7_A0.8651.00
18_V65_Q0.8501.00
38_L41_Q0.8491.00
37_V42_A0.8341.00
65_Q68_A0.8271.00
21_K59_V0.8010.99
22_T54_A0.7980.99
19_N65_Q0.7980.99
2_A6_A0.7930.99
18_V72_A0.7920.99
23_F61_L0.7880.99
21_K55_D0.7840.99
85_R88_K0.7800.99
36_A66_L0.7710.99
40_A43_A0.7650.99
81_F85_R0.7470.99
32_R35_G0.7410.99
89_A93_A0.7320.99
32_R77_V0.7270.99
33_I73_V0.7270.99
27_R32_R0.7140.99
88_K92_E0.7130.99
23_F53_T0.7130.99
11_A83_A0.7120.99
50_T58_F0.7120.99
29_S32_R0.7020.98
4_I88_K0.7000.98
90_A94_A0.6980.98
91_I100_V0.6950.98
30_Q35_G0.6730.98
64_A68_A0.6680.98
86_A90_A0.6680.98
47_G60_T0.6670.98
70_A74_A0.6620.98
32_R81_F0.6590.98
28_E31_A0.6580.98
44_P64_A0.6530.98
37_V66_L0.6480.97
82_A86_A0.6430.97
3_E6_A0.6430.97
13_T30_Q0.6430.97
36_A74_A0.6390.97
49_P60_T0.6340.97
39_A71_A0.6290.97
8_R12_E0.6270.97
25_T76_H0.6190.97
38_L42_A0.6130.96
12_E77_V0.6130.96
44_P48_T0.6120.96
31_A34_T0.6080.96
16_F25_T0.6060.96
79_A82_A0.6040.96
89_A92_E0.5970.96
6_A9_D0.5950.96
13_T27_R0.5880.95
49_P82_A0.5860.95
2_A5_K0.5830.95
22_T55_D0.5810.95
4_I87_L0.5790.95
29_S51_W0.5740.95
50_T82_A0.5730.95
33_I70_A0.5730.95
36_A78_Q0.5710.95
56_N88_K0.5690.95
14_G76_H0.5650.94
30_Q34_T0.5650.94
35_G77_V0.5640.94
35_G70_A0.5600.94
58_F85_R0.5410.93
76_H79_A0.5350.93
49_P85_R0.5330.92
73_V77_V0.5240.92
52_K56_N0.5230.92
67_I70_A0.5210.92
80_C83_A0.5160.91
83_A94_A0.5110.91
42_A67_I0.5090.91
72_A75_A0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4glwA 2 0.5 16.9 0.863 Contact Map
3uq8A 1 0.5588 11.7 0.873 Contact Map
1zauA 1 0.5098 10.8 0.875 Contact Map
4lh6A 1 0.549 7.8 0.882 Contact Map
1kq3A 5 0.7451 7.5 0.883 Contact Map
3jslA 2 0.4902 6.6 0.886 Contact Map
1b04A 1 0.5098 5.2 0.891 Contact Map
3uhjA 5 0.7255 5 0.893 Contact Map
2xb0X 1 0.7451 4.7 0.894 Contact Map
1jq5A 5 0.7353 4.4 0.896 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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