GREMLIN Database
PP2 - Phloem protein 2
PFAM: PF14299 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (136)
Sequences: 1161 (790)
Seq/√Len: 67.7
META: 0.053

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_C125_W5.0811.00
15_W44_W4.0541.00
47_I131_V3.0671.00
9_R35_E2.9091.00
75_Y127_G2.9011.00
106_F113_V2.6001.00
15_W21_Y2.5161.00
49_G115_F2.5071.00
41_Q127_G2.4571.00
115_F136_I2.2271.00
9_R24_W2.2161.00
100_E137_R2.1731.00
41_Q125_W2.0491.00
13_I37_A1.9671.00
21_Y44_W1.9201.00
23_R38_E1.8861.00
15_W42_V1.8321.00
21_Y43_C1.8201.00
43_C123_G1.8081.00
59_G108_N1.8071.00
50_K112_E1.7581.00
70_L77_W1.6971.00
77_W82_V1.6961.00
31_S132_E1.5720.99
8_A11_L1.5680.99
66_F117_L1.5120.99
94_R100_E1.5100.99
38_E71_G1.4720.99
83_E121_D1.4480.98
8_A24_W1.4100.98
65_Y137_R1.4080.98
56_L60_T1.4050.98
5_M67_V1.3960.98
23_R40_L1.3780.98
66_F103_L1.3620.98
22_W128_G1.3600.98
14_T46_E1.3480.97
46_E120_I1.3460.97
9_R13_I1.3400.97
94_R97_G1.3080.97
13_I22_W1.2910.97
64_A134_I1.2620.96
52_E112_E1.2420.96
96_D100_E1.2380.96
14_T125_W1.2220.95
115_F134_I1.1940.95
39_L44_W1.1860.95
8_A131_V1.1770.94
97_G100_E1.1470.94
46_E116_S1.1460.94
128_G131_V1.1380.93
4_Y51_I1.1210.93
99_M113_V1.1050.92
54_R92_K1.0840.92
57_S60_T1.0750.91
87_S114_E1.0720.91
133_G137_R1.0640.91
4_Y28_L1.0460.90
83_E86_V1.0440.90
15_W125_W1.0390.90
92_K120_I1.0390.90
112_E115_F1.0350.90
86_V89_G1.0260.89
66_F77_W1.0080.88
18_D21_Y1.0040.88
60_T67_V0.9980.88
22_W49_G0.9950.88
6_L11_L0.9940.88
130_I133_G0.9760.87
72_D88_L0.9650.86
23_R73_R0.9580.86
60_T65_Y0.9560.85
41_Q121_D0.9390.84
74_A81_P0.9350.84
91_P94_R0.9290.84
91_P130_I0.9280.84
39_L46_E0.9210.83
30_E69_K0.8980.82
14_T21_Y0.8980.82
39_L126_K0.8950.81
100_E133_G0.8940.81
54_R84_F0.8840.81
14_T18_D0.8770.80
90_G97_G0.8740.80
48_R118_Y0.8660.79
26_S36_V0.8620.79
42_V126_K0.8520.78
116_S136_I0.8420.77
12_S17_D0.8410.77
56_L62_Y0.8370.77
14_T86_V0.8360.77
65_Y135_E0.8310.76
56_L67_V0.8280.76
79_I82_V0.8220.76
42_V125_W0.8220.76
44_W126_K0.8220.76
15_W18_D0.8120.75
91_P97_G0.8120.75
2_K132_E0.8050.74
100_E107_F0.7990.74
45_L84_F0.7970.73
20_R41_Q0.7970.73
83_E89_G0.7960.73
43_C124_H0.7940.73
2_K7_S0.7890.73
98_W104_G0.7850.72
59_G71_G0.7810.72
60_T101_I0.7800.72
72_D124_H0.7720.71
68_F84_F0.7580.70
68_F89_G0.7570.69
6_L101_I0.7540.69
51_I56_L0.7530.69
79_I90_G0.7510.69
13_I21_Y0.7430.68
40_L125_W0.7400.68
22_W39_L0.7390.68
58_P62_Y0.7370.67
61_T107_F0.7340.67
81_P122_G0.7290.67
5_M133_G0.7280.66
45_L50_K0.7270.66
45_L129_L0.7270.66
65_Y133_G0.7250.66
75_Y78_D0.7190.66
52_E111_G0.7060.64
96_D102_E0.7060.64
24_W37_A0.7050.64
52_E117_L0.7050.64
53_T113_V0.6960.63
41_Q75_Y0.6940.63
114_E127_G0.6910.62
11_L134_I0.6840.62
33_F102_E0.6740.61
13_I110_D0.6690.60
59_G63_A0.6620.59
109_E112_E0.6580.59
100_E135_E0.6570.59
35_E64_A0.6520.58
3_C7_S0.6500.58
7_S33_F0.6490.58
6_L93_E0.6480.58
76_G126_K0.6460.57
56_L69_K0.6420.57
32_R96_D0.6400.57
45_L56_L0.6400.57
77_W84_F0.6390.56
7_S46_E0.6380.56
31_S67_V0.6320.56
8_A37_A0.6310.56
92_K136_I0.6290.55
20_R23_R0.6250.55
14_T44_W0.6180.54
15_W43_C0.6170.54
15_W22_W0.6120.53
11_L50_K0.6090.53
30_E46_E0.6090.53
8_A67_V0.6090.53
16_G19_P0.5960.51
23_R99_M0.5910.51
7_S136_I0.5880.50
25_I38_E0.5880.50
119_E128_G0.5880.50
20_R54_R0.5870.50
33_F100_E0.5830.50
117_L131_V0.5830.50
13_I24_W0.5820.50
63_A67_V0.5820.50
23_R82_V0.5780.49
74_A124_H0.5780.49
106_F111_G0.5780.49
105_E136_I0.5770.49
18_D131_V0.5750.49
45_L118_Y0.5700.48
119_E124_H0.5680.48
26_S29_P0.5670.48
63_A137_R0.5670.48
116_S122_G0.5600.47
45_L117_L0.5580.47
50_K114_E0.5530.46
18_D123_G0.5530.46
76_G81_P0.5510.46
10_A136_I0.5500.46
53_T58_P0.5460.45
72_D79_I0.5450.45
40_L70_L0.5450.45
71_G101_I0.5410.45
69_K130_I0.5390.45
71_G127_G0.5380.44
61_T115_F0.5380.44
4_Y38_E0.5350.44
77_W101_I0.5330.44
47_I71_G0.5310.44
20_R71_G0.5310.44
72_D113_V0.5310.44
133_G138_P0.5280.43
34_S63_A0.5250.43
61_T117_L0.5210.42
35_E111_G0.5190.42
24_W56_L0.5190.42
29_P36_V0.5130.42
64_A67_V0.5100.41
53_T82_V0.5070.41
6_L10_A0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dyoA 1 0.9203 46.9 0.916 Contact Map
4xupA 1 0.9275 11 0.938 Contact Map
1bquA 2 0.6739 8.5 0.941 Contact Map
4xurA 1 0.8986 8.3 0.942 Contact Map
2q7nA 3 0.6087 5.7 0.946 Contact Map
4xuoA 1 0.8986 5.6 0.946 Contact Map
1i1rA 1 0.6159 5.1 0.947 Contact Map
3csgA 1 0.5362 5 0.947 Contact Map
2ocfD 1 0.5797 4.9 0.948 Contact Map
1fnfA 1 0.587 4.8 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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