GREMLIN Database
DUF4373 - Domain of unknown function (DUF4373)
PFAM: PF14297 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 96 (93)
Sequences: 5159 (4362)
Seq/√Len: 452.3
META: 0.952

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
24_E66_K2.9351.00
18_R31_K2.7621.00
28_I70_I2.5611.00
21_Y73_Y2.4841.00
15_K59_K2.4261.00
4_H30_W2.3391.00
23_L31_K2.2361.00
20_K73_Y2.1981.00
6_V37_Y2.1951.00
23_L27_G2.1691.00
7_N38_E2.0931.00
4_H34_E1.9881.00
8_A30_W1.9081.00
82_K86_E1.8591.00
68_K72_N1.8541.00
10_N38_E1.6411.00
21_Y69_E1.5291.00
29_Y33_L1.5271.00
26_Y34_E1.4831.00
4_H8_A1.4591.00
26_Y31_K1.4491.00
47_D50_L1.3591.00
17_L74_C1.3481.00
29_Y79_L1.3391.00
28_I67_V1.3291.00
66_K69_E1.2991.00
15_K56_A1.2801.00
9_R31_K1.2411.00
37_Y42_Y1.2311.00
75_V85_F1.2101.00
81_D94_K1.1911.00
21_Y70_I1.1731.00
83_E87_K1.1661.00
73_Y77_L1.1451.00
63_D66_K1.1221.00
51_I68_K1.1191.00
35_L38_E1.0891.00
26_Y30_W1.0861.00
2_F34_E1.0611.00
43_Y90_I1.0601.00
18_R26_Y1.0471.00
12_P35_L1.0431.00
74_C80_F1.0411.00
71_I75_V1.0381.00
49_D77_L1.0361.00
35_L39_N1.0321.00
51_I55_A1.0271.00
64_E68_K1.0201.00
21_Y25_G1.0131.00
8_A26_Y1.0081.00
73_Y76_E0.9861.00
70_I74_C0.9781.00
66_K70_I0.9701.00
75_V80_F0.9641.00
50_L53_L0.9561.00
84_L88_D0.9521.00
15_K18_R0.9471.00
65_E69_E0.9441.00
15_K19_A0.9411.00
19_A56_A0.9371.00
19_A53_L0.9231.00
46_W50_L0.9141.00
9_R38_E0.9121.00
46_W51_I0.9021.00
62_V66_K0.8971.00
30_W34_E0.8921.00
23_L28_I0.8821.00
56_A61_G0.8811.00
48_E52_L0.8751.00
17_L25_G0.8611.00
17_L70_I0.8521.00
20_K77_L0.8471.00
14_I17_L0.8431.00
16_K53_L0.8351.00
20_K52_L0.8251.00
52_L56_A0.8231.00
52_L55_A0.8141.00
12_P39_N0.8021.00
18_R61_G0.8021.00
32_L71_I0.7931.00
29_Y74_C0.7801.00
14_I26_Y0.7781.00
84_L90_I0.7731.00
62_V67_V0.7691.00
35_L44_L0.7671.00
16_K77_L0.7601.00
17_L29_Y0.7551.00
10_N59_K0.7531.00
74_C79_L0.7521.00
18_R23_L0.7471.00
14_I29_Y0.7351.00
9_R34_E0.7301.00
20_K69_E0.7301.00
24_E27_G0.6961.00
9_R35_L0.6961.00
24_E62_V0.6941.00
2_F30_W0.6871.00
16_K20_K0.6771.00
10_N34_E0.6721.00
6_V38_E0.6471.00
69_E76_E0.6431.00
16_K19_A0.6431.00
20_K49_D0.6300.99
4_H26_Y0.6220.99
5_D8_A0.6220.99
16_K49_D0.6140.99
27_G31_K0.6030.99
69_E73_Y0.5980.99
52_L64_E0.5980.99
80_F91_L0.5920.99
29_Y80_F0.5900.99
48_E76_E0.5880.99
49_D52_L0.5860.99
53_L56_A0.5800.99
89_G92_T0.5710.99
45_E48_E0.5660.99
45_E90_I0.5630.99
13_K79_L0.5610.99
13_K95_G0.5600.99
18_R56_A0.5580.99
36_L40_E0.5520.98
31_K60_L0.5510.98
50_L54_F0.5500.98
49_D53_L0.5490.98
67_V70_I0.5440.98
49_D76_E0.5430.98
83_E92_T0.5390.98
8_A34_E0.5360.98
23_L60_L0.5350.98
30_W33_L0.5200.98
78_G81_D0.5200.98
19_A61_G0.5190.98
13_K33_L0.5120.98
82_K88_D0.5110.98
23_L26_Y0.5100.97
83_E86_E0.5090.97
49_D78_G0.5080.97
45_E89_G0.5030.97
31_K59_K0.5010.97
51_I54_F0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4y66A 1 0.7188 49.5 0.829 Contact Map
4ptaD 3 0.875 40 0.838 Contact Map
4pt7A 3 0.9375 38.2 0.84 Contact Map
1z7uA 2 0.8438 23.5 0.857 Contact Map
2xvcA 1 0.5833 18.2 0.863 Contact Map
2o03A 2 0.7917 18.2 0.863 Contact Map
4y66B 1 0.7083 18.2 0.863 Contact Map
1fc3A 3 0.9375 17.8 0.864 Contact Map
3r4kA 2 0.6771 16.9 0.866 Contact Map
2fu4A 2 0.8438 16.6 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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