GREMLIN Database
O-ag_pol_Wzy - O-antigen polysaccharide polymerase Wzy
PFAM: PF14296 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 447 (429)
Sequences: 1343 (1297)
Seq/√Len: 62.6
META: 0.754

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
375_A387_F9.0351.00
91_G388_M6.7611.00
94_S385_I5.6701.00
315_T378_N5.3311.00
98_G392_G5.1461.00
379_F383_G4.9111.00
263_G266_R4.8651.00
432_R436_W4.8051.00
371_Y388_M3.7011.00
374_E378_N3.4841.00
87_L384_V3.2971.00
297_T373_A3.2511.00
351_W369_F3.2101.00
98_G389_F3.1811.00
156_G159_A3.1371.00
368_G424_R3.0121.00
313_G379_F2.8871.00
313_G378_N2.6631.00
46_F50_F2.6341.00
348_L351_W2.6051.00
325_P328_F2.6031.00
91_G98_G2.5941.00
369_F378_N2.5441.00
421_F425_G2.3471.00
369_F375_A2.3171.00
91_G384_V2.2991.00
214_G368_G2.2761.00
91_G95_F2.2581.00
241_K244_K2.2461.00
325_P329_G2.2461.00
130_G182_A2.1871.00
311_T315_T2.1511.00
220_I259_L2.1451.00
316_Y378_N2.1291.00
301_V377_L2.1251.00
283_F287_Q2.1231.00
102_F393_F2.0501.00
130_G137_S2.0451.00
370_S424_R2.0441.00
433_P436_W2.0411.00
329_G332_P2.0181.00
371_Y375_A2.0161.00
94_S98_G1.9941.00
326_N332_P1.9731.00
372_I388_M1.9621.00
375_A378_N1.9611.00
392_G396_R1.9521.00
370_S373_A1.9381.00
88_S91_G1.9331.00
98_G102_F1.9231.00
288_G293_V1.9231.00
217_G421_F1.8981.00
313_G316_Y1.8641.00
328_F332_P1.8351.00
366_G369_F1.8331.00
231_F234_N1.8291.00
338_S342_A1.8271.00
43_Y96_L1.7881.00
217_G221_L1.7570.99
228_W232_Y1.7520.99
326_N329_G1.7060.99
157_Y368_G1.7030.99
348_L353_T1.7000.99
339_V342_A1.7000.99
312_Y315_T1.6610.99
295_A298_I1.6590.99
345_G348_L1.6210.99
433_P437_Y1.6000.99
129_V394_L1.5920.99
328_F331_I1.5860.99
50_F53_F1.5520.99
42_P47_L1.5410.99
423_P426_S1.5390.99
286_E290_S1.5230.99
369_F426_S1.5160.98
221_L421_F1.5070.98
49_T423_P1.4890.98
315_T318_Y1.4880.98
138_F142_L1.4820.98
337_N341_L1.4650.98
133_L246_I1.4600.98
39_I42_P1.4530.98
376_Y380_G1.4450.98
102_F396_R1.4310.98
302_D305_P1.4300.98
52_L425_G1.4290.98
323_I332_P1.4250.98
369_F374_E1.4230.98
372_I384_V1.4100.98
305_P308_E1.3900.97
391_L422_L1.3880.97
293_V298_I1.3840.97
41_S399_Y1.3800.97
376_Y381_Y1.3790.97
56_G288_G1.3750.97
324_I328_F1.3730.97
292_R295_A1.3710.97
87_L372_I1.3690.97
397_K401_K1.3690.97
53_F369_F1.3670.97
370_S374_E1.3660.97
316_Y374_E1.3630.97
54_L57_R1.3580.97
22_L26_F1.3560.97
426_S429_S1.3540.97
229_Y233_R1.3250.96
152_V156_G1.3210.96
40_F44_F1.3170.96
364_G370_S1.3100.96
260_S263_G1.3090.96
95_F412_Y1.3050.96
358_P367_L1.2950.96
295_A372_I1.2930.96
87_L91_G1.2870.96
369_F377_L1.2820.96
313_G317_L1.2770.96
243_K254_V1.2730.95
301_V305_P1.2630.95
178_F319_F1.2610.95
15_L18_L1.2580.95
208_L212_L1.2540.95
217_G291_F1.2420.95
222_L394_L1.2350.95
320_L325_P1.2300.95
371_Y374_E1.2260.94
284_F287_Q1.2220.94
325_P332_P1.2210.94
283_F286_E1.2180.94
133_L137_S1.2150.94
388_M392_G1.2140.94
335_S338_S1.2130.94
98_G132_I1.2020.94
41_S54_L1.2020.94
369_F373_A1.2010.94
42_P399_Y1.1940.94
239_K253_I1.1900.93
297_T301_V1.1900.93
352_L367_L1.1830.93
53_F370_S1.1750.93
349_S352_L1.1630.93
263_G286_E1.1580.93
353_T365_G1.1580.93
378_N426_S1.1560.92
216_R424_R1.1530.92
210_S213_T1.1500.92
436_W439_I1.1490.92
348_L369_F1.1420.92
53_F56_G1.1400.92
99_Y387_F1.1400.92
338_S341_L1.1340.92
95_F392_G1.1310.92
64_F129_V1.1250.91
161_Y361_Y1.1140.91
99_Y392_G1.0970.90
225_A390_L1.0970.90
99_Y396_R1.0940.90
118_Y390_L1.0930.90
284_F387_F1.0890.90
291_F295_A1.0890.90
338_S374_E1.0880.90
426_S432_R1.0850.90
87_L381_Y1.0840.90
101_L105_K1.0830.90
126_L130_G1.0780.90
290_S293_V1.0670.89
290_S352_L1.0650.89
146_Y419_L1.0650.89
305_P313_G1.0650.89
395_L419_L1.0640.89
205_L208_L1.0640.89
320_L332_P1.0620.89
38_K41_S1.0440.88
311_T378_N1.0440.88
429_S433_P1.0400.88
229_Y413_L1.0390.88
349_S366_G1.0390.88
211_L219_F1.0380.88
77_S80_I1.0380.88
202_L404_R1.0370.88
168_L220_I1.0310.87
348_L374_E1.0290.87
368_G374_E1.0270.87
122_L126_L1.0250.87
373_A377_L1.0240.87
117_S254_V1.0230.87
39_I44_F1.0190.87
438_L442_L1.0170.87
238_K242_K1.0150.87
375_A422_L1.0080.86
375_A388_M1.0070.86
84_A88_S1.0070.86
54_L369_F1.0010.86
327_L401_K0.9960.86
378_N423_P0.9950.85
97_L385_I0.9940.85
256_L268_G0.9910.85
396_R399_Y0.9870.85
257_V266_R0.9860.85
127_R130_G0.9850.85
219_F432_R0.9850.85
174_L177_S0.9840.85
369_F423_P0.9750.84
323_I328_F0.9740.84
288_G291_F0.9730.84
262_I265_I0.9690.84
48_I56_G0.9660.84
24_L32_Y0.9640.84
54_L423_P0.9640.84
288_G368_G0.9560.83
146_Y150_L0.9560.83
289_G293_V0.9540.83
85_L89_L0.9520.83
382_L390_L0.9500.83
247_L250_L0.9500.83
135_L324_I0.9490.83
95_F395_L0.9460.82
91_G392_G0.9460.82
356_L367_L0.9440.82
95_F348_L0.9440.82
422_L425_G0.9380.82
213_T365_G0.9370.82
420_L431_L0.9360.82
84_A296_Y0.9300.81
84_A295_A0.9280.81
175_L178_F0.9280.81
348_L357_N0.9230.81
53_F217_G0.9220.81
235_R239_K0.9150.80
168_L400_K0.9140.80
168_L306_N0.9140.80
230_Y235_R0.9140.80
316_Y375_A0.9110.80
369_F425_G0.9100.80
143_L258_L0.9090.80
129_V144_Y0.9080.80
14_N17_F0.9070.80
286_E295_A0.8990.79
185_L249_L0.8970.79
288_G370_S0.8960.79
378_N428_L0.8940.79
313_G321_S0.8930.79
227_L231_F0.8930.79
121_K194_K0.8920.79
432_R435_L0.8890.78
219_F222_L0.8890.78
128_K205_L0.8870.78
335_S341_L0.8870.78
217_G429_S0.8860.78
368_G375_A0.8770.77
94_S389_F0.8770.77
197_L202_L0.8760.77
221_L377_L0.8710.77
176_S370_S0.8680.77
399_Y412_Y0.8680.77
50_F54_L0.8660.76
324_I332_P0.8650.76
325_P331_I0.8650.76
300_Y369_F0.8620.76
43_Y53_F0.8620.76
322_G329_G0.8610.76
178_F187_L0.8590.76
360_A365_G0.8590.76
376_Y379_F0.8580.76
378_N427_F0.8580.76
72_G75_F0.8560.76
38_K42_P0.8540.75
422_L430_F0.8490.75
235_R238_K0.8480.75
94_S382_L0.8460.75
230_Y238_K0.8450.75
112_K136_I0.8430.75
116_L134_F0.8430.75
169_P329_G0.8410.74
255_L349_S0.8410.74
311_T314_K0.8400.74
53_F290_S0.8390.74
294_L297_T0.8380.74
178_F182_A0.8370.74
367_L423_P0.8370.74
419_L444_I0.8350.74
417_P425_G0.8290.73
436_W440_I0.8290.73
269_G373_A0.8220.73
286_E368_G0.8200.72
369_F424_R0.8200.72
30_I205_L0.8170.72
337_N340_E0.8170.72
366_G373_A0.8140.72
197_L240_I0.8140.72
46_F54_L0.8110.72
434_L439_I0.8100.72
90_L117_S0.8090.71
62_Y65_G0.8090.71
43_Y50_F0.8090.71
271_I384_V0.8060.71
53_F57_R0.8050.71
52_L228_W0.8030.71
374_E379_F0.8010.71
214_G290_S0.8000.71
249_L254_V0.7990.70
427_F430_F0.7980.70
336_G350_D0.7970.70
29_L49_T0.7940.70
29_L33_S0.7930.70
198_L376_Y0.7920.70
230_Y234_N0.7900.70
101_L224_L0.7870.69
260_S266_R0.7870.69
194_K197_L0.7860.69
321_S325_P0.7840.69
205_L310_Y0.7840.69
287_Q369_F0.7840.69
35_K38_K0.7820.69
123_I127_R0.7800.69
389_F393_F0.7790.69
40_F43_Y0.7740.68
317_L320_L0.7730.68
97_L101_L0.7720.68
433_P438_L0.7670.67
157_Y288_G0.7670.67
158_L161_Y0.7660.67
288_G294_L0.7660.67
248_L327_L0.7640.67
384_V392_G0.7620.67
290_S368_G0.7600.67
101_L104_K0.7600.67
415_L425_G0.7580.66
396_R400_K0.7580.66
254_V291_F0.7570.66
136_I202_L0.7560.66
316_Y319_F0.7550.66
15_L19_L0.7540.66
29_L204_L0.7530.66
98_G388_M0.7530.66
284_F310_Y0.7530.66
357_N367_L0.7520.66
262_I281_L0.7500.66
78_E382_L0.7490.65
252_A257_V0.7490.65
224_L283_F0.7460.65
376_Y384_V0.7460.65
351_W355_L0.7450.65
45_L306_N0.7400.65
91_G139_L0.7400.65
373_A399_Y0.7370.64
45_L49_T0.7350.64
247_L251_L0.7350.64
14_N19_L0.7350.64
216_R366_G0.7310.64
84_A314_K0.7290.63
87_L98_G0.7270.63
28_L32_Y0.7270.63
132_I404_R0.7260.63
153_L156_G0.7250.63
295_A374_E0.7220.63
419_L425_G0.7210.63
47_L92_L0.7200.62
98_G232_Y0.7200.62
374_E426_S0.7190.62
52_L56_G0.7180.62
91_G94_S0.7170.62
293_V383_G0.7170.62
84_A376_Y0.7160.62
40_F208_L0.7130.62
53_F58_P0.7130.62
27_I45_L0.7120.62
210_S216_R0.7120.62
189_S349_S0.7110.61
51_F54_L0.7100.61
297_T348_L0.7090.61
12_F16_S0.7090.61
351_W357_N0.7090.61
153_L157_Y0.7070.61
55_F89_L0.7070.61
53_F225_A0.7040.61
27_I385_I0.7040.61
397_K400_K0.7030.61
48_I392_G0.7020.60
353_T392_G0.7010.60
297_T369_F0.7000.60
12_F15_L0.6990.60
201_L328_F0.6980.60
124_K155_G0.6960.60
201_L205_L0.6950.60
30_I209_L0.6940.60
173_S240_I0.6910.59
54_L370_S0.6910.59
224_L257_V0.6890.59
286_E289_G0.6860.59
96_L290_S0.6850.59
251_L255_L0.6850.59
203_F219_F0.6850.59
369_F421_F0.6850.59
118_Y240_I0.6840.58
384_V388_M0.6820.58
134_F182_A0.6790.58
26_F205_L0.6790.58
421_F428_L0.6780.58
60_L65_G0.6770.58
273_S385_I0.6770.58
136_I197_L0.6760.58
135_L150_L0.6760.58
243_K339_V0.6740.57
398_L430_F0.6740.57
31_I144_Y0.6720.57
382_L435_L0.6710.57
319_F326_N0.6700.57
185_L407_F0.6700.57
99_Y102_F0.6690.57
434_L437_Y0.6690.57
92_L428_L0.6680.57
203_F372_I0.6670.57
143_L254_V0.6670.57
30_I33_S0.6670.57
305_P310_Y0.6640.56
246_I251_L0.6630.56
46_F51_F0.6620.56
373_A425_G0.6620.56
378_N422_L0.6600.56
243_K246_I0.6570.55
214_G424_R0.6570.55
13_N17_F0.6570.55
293_V422_L0.6550.55
250_L264_Y0.6550.55
419_L426_S0.6550.55
340_E344_E0.6550.55
352_L356_L0.6530.55
142_L151_Y0.6530.55
22_L29_L0.6530.55
232_Y379_F0.6510.55
327_L348_L0.6510.55
170_G181_I0.6500.55
255_L407_F0.6480.54
88_S294_L0.6470.54
84_A291_F0.6470.54
36_K41_S0.6460.54
301_V304_L0.6460.54
216_R352_L0.6450.54
261_L297_T0.6440.54
85_L300_Y0.6430.54
63_F66_Y0.6430.54
310_Y314_K0.6430.54
217_G420_L0.6410.54
41_S376_Y0.6410.54
91_G383_G0.6410.54
44_F48_I0.6390.53
207_L392_G0.6360.53
378_N388_M0.6360.53
91_G372_I0.6350.53
378_N383_G0.6350.53
338_S348_L0.6350.53
319_F325_P0.6350.53
275_S282_D0.6330.53
180_L386_I0.6330.53
219_F372_I0.6330.53
162_T211_L0.6320.53
94_S101_L0.6310.52
74_D136_I0.6310.52
130_G140_P0.6290.52
137_S140_P0.6290.52
304_L430_F0.6290.52
217_G329_G0.6280.52
14_N23_L0.6280.52
91_G371_Y0.6280.52
216_R260_S0.6270.52
109_L247_L0.6260.52
287_Q293_V0.6260.52
90_L381_Y0.6230.52
251_L324_I0.6220.51
127_R137_S0.6220.51
130_G187_L0.6210.51
217_G369_F0.6190.51
289_G365_G0.6190.51
194_K405_N0.6180.51
225_A416_L0.6180.51
432_R437_Y0.6180.51
375_A427_F0.6170.51
127_R152_V0.6170.51
317_L378_N0.6170.51
310_Y444_I0.6160.51
325_P377_L0.6120.50
287_Q301_V0.6110.50
19_L139_L0.6110.50
131_L394_L0.6110.50
222_L365_G0.6100.50
233_R288_G0.6100.50
191_P195_K0.6080.50
126_L403_K0.6080.50
313_G320_L0.6060.50
159_A190_K0.6060.50
96_L102_F0.6050.49
123_I324_I0.6050.49
186_F189_S0.6050.49
12_F19_L0.6040.49
137_S371_Y0.6020.49
252_A256_L0.6000.49
358_P364_G0.5990.49
171_L174_L0.5980.49
391_L419_L0.5960.48
101_L110_N0.5960.48
141_F145_L0.5960.48
358_P362_L0.5940.48
81_I248_L0.5940.48
220_I258_L0.5930.48
38_K399_Y0.5920.48
337_N342_A0.5920.48
50_F220_I0.5920.48
157_Y266_R0.5900.48
240_I262_I0.5880.48
315_T332_P0.5880.48
157_Y186_F0.5870.47
321_S324_I0.5850.47
202_L244_K0.5850.47
423_P428_L0.5840.47
192_S240_I0.5840.47
25_I305_P0.5830.47
21_L152_V0.5820.47
34_L241_K0.5820.47
157_Y364_G0.5810.47
49_T53_F0.5810.47
25_I202_L0.5790.47
309_P313_G0.5790.47
148_G310_Y0.5780.46
58_P62_Y0.5770.46
152_V346_N0.5770.46
176_S181_I0.5770.46
95_F248_L0.5760.46
336_G342_A0.5760.46
346_N349_S0.5750.46
228_W332_P0.5740.46
240_I421_F0.5740.46
225_A229_Y0.5730.46
189_S250_L0.5730.46
48_I101_L0.5700.45
41_S129_V0.5700.45
23_L281_L0.5690.45
217_G366_G0.5680.45
74_D254_V0.5680.45
213_T377_L0.5680.45
168_L176_S0.5670.45
366_G425_G0.5670.45
161_Y347_S0.5670.45
76_F81_I0.5670.45
410_A420_L0.5670.45
157_Y173_S0.5660.45
31_I139_L0.5660.45
215_S367_L0.5660.45
353_T369_F0.5660.45
228_W357_N0.5640.45
371_Y423_P0.5640.45
262_I266_R0.5640.45
101_L249_L0.5630.45
99_Y425_G0.5600.44
127_R131_L0.5600.44
59_F323_I0.5590.44
301_V372_I0.5590.44
309_P376_Y0.5580.44
215_S373_A0.5570.44
65_G407_F0.5570.44
131_L135_L0.5550.44
291_F369_F0.5540.44
317_L325_P0.5540.44
62_Y66_Y0.5530.44
118_Y223_L0.5530.44
75_F89_L0.5530.44
352_L357_N0.5520.43
411_L437_Y0.5520.43
206_Y374_E0.5510.43
417_P439_I0.5510.43
82_N372_I0.5500.43
266_R288_G0.5500.43
176_S183_L0.5490.43
48_I193_K0.5470.43
148_G164_F0.5470.43
99_Y326_N0.5470.43
22_L30_I0.5460.43
351_W366_G0.5450.43
162_T220_I0.5450.43
21_L224_L0.5440.43
323_I391_L0.5430.42
29_L32_Y0.5410.42
229_Y283_F0.5410.42
401_K404_R0.5410.42
23_L386_I0.5410.42
360_A363_S0.5410.42
353_T357_N0.5400.42
308_E393_F0.5400.42
128_K199_I0.5400.42
254_V441_L0.5380.42
230_Y395_L0.5380.42
259_L404_R0.5370.42
381_Y410_A0.5360.42
300_Y304_L0.5360.42
180_L390_L0.5350.42
80_I83_K0.5340.41
194_K254_V0.5340.41
149_L153_L0.5340.41
187_L253_I0.5330.41
23_L27_I0.5320.41
316_Y321_S0.5310.41
80_I227_L0.5280.41
58_P64_F0.5270.41
194_K397_K0.5270.41
393_F401_K0.5270.41
25_I197_L0.5260.41
70_I73_L0.5260.41
433_P439_I0.5260.41
217_G365_G0.5250.40
389_F437_Y0.5220.40
29_L393_F0.5220.40
249_L263_G0.5220.40
284_F288_G0.5220.40
58_P256_L0.5210.40
113_K133_L0.5210.40
196_L252_A0.5200.40
305_P351_W0.5200.40
115_L398_L0.5180.40
200_L207_L0.5170.40
252_A274_S0.5160.39
339_V343_L0.5130.39
60_L67_Y0.5120.39
225_A373_A0.5120.39
66_Y278_N0.5120.39
83_K282_D0.5120.39
215_S421_F0.5110.39
350_D361_Y0.5110.39
219_F373_A0.5110.39
182_A291_F0.5100.39
262_I420_L0.5090.39
129_V137_S0.5090.39
375_A383_G0.5070.38
185_L291_F0.5070.38
125_N128_K0.5070.38
201_L409_L0.5070.38
105_K108_K0.5060.38
206_Y411_L0.5050.38
241_K251_L0.5040.38
46_F221_L0.5020.38
178_F185_L0.5020.38
145_L152_V0.5010.38
345_G351_W0.5010.38
261_L265_I0.5010.38
218_P358_P0.5000.38
29_L47_L0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwaA 2 0.0984 1.8 0.969 Contact Map
3giaA 1 0.226 1.4 0.971 Contact Map
2l2tA 2 0.0984 1.2 0.972 Contact Map
1iijA 1 0.0783 1.2 0.972 Contact Map
2ks1B 1 0.0984 1.1 0.973 Contact Map
2ksfA 1 0.2304 1.1 0.973 Contact Map
2l9uA 2 0.0872 0.9 0.974 Contact Map
1v54B 1 0.1611 0.7 0.976 Contact Map
2gsmB 1 0.1834 0.7 0.976 Contact Map
4b19A 1 0.0671 0.7 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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