GREMLIN Database
DUF4372 - Domain of unknown function (DUF4372)
PFAM: PF14294 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (72)
Sequences: 19671 (8056)
Seq/√Len: 949.4
META: 0.982

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_S38_D3.0621.00
15_R37_W3.0521.00
37_W41_V2.4331.00
10_L41_V2.2931.00
27_G36_C2.1501.00
15_R19_D2.1091.00
26_G29_R2.0541.00
10_L44_L1.9531.00
17_E20_R1.8731.00
3_K11_D1.8521.00
16_H20_R1.6871.00
28_D36_C1.5251.00
40_F44_L1.5101.00
64_H67_K1.4861.00
45_F60_C1.4021.00
17_E21_L1.3811.00
3_K7_S1.3711.00
51_R56_D1.3621.00
18_F22_V1.3351.00
31_V36_C1.3311.00
19_D23_K1.3171.00
34_F42_A1.2751.00
8_Q11_D1.2531.00
28_D31_V1.2461.00
22_V36_C1.2401.00
16_H19_D1.2391.00
14_P17_E1.2371.00
18_F37_W1.2291.00
36_C39_Q1.2031.00
7_S11_D1.2021.00
13_L40_F1.1191.00
61_L68_L1.0951.00
58_E62_R1.0891.00
62_R65_S1.0501.00
21_L24_R1.0231.00
31_V35_S0.9951.00
64_H71_L0.9791.00
46_A57_I0.9691.00
31_V34_F0.9621.00
21_L25_Y0.9561.00
41_V73_I0.9501.00
38_D73_I0.9461.00
62_R68_L0.9341.00
4_T71_L0.9321.00
18_F40_F0.9261.00
39_Q43_M0.9211.00
34_F38_D0.9191.00
19_D37_W0.9131.00
29_R32_R0.8921.00
61_L73_I0.8911.00
52_E56_D0.8801.00
6_F45_F0.8771.00
18_F36_C0.8741.00
68_L73_I0.8601.00
51_R57_I0.8411.00
42_A73_I0.8381.00
22_V27_G0.8261.00
54_L58_E0.8241.00
20_R23_K0.7921.00
9_L48_L0.7801.00
6_F41_V0.7711.00
27_G31_V0.7611.00
34_F45_F0.7571.00
45_F49_T0.7401.00
21_L27_G0.7311.00
66_G69_Y0.7191.00
42_A46_A0.7171.00
10_L37_W0.7101.00
30_Y36_C0.7091.00
19_D28_D0.7071.00
56_D59_A0.7061.00
30_Y33_S0.7021.00
28_D32_R0.7011.00
46_A54_L0.6921.00
59_A62_R0.6921.00
20_R24_R0.6821.00
39_Q54_L0.6621.00
4_T46_A0.6601.00
44_L48_L0.6581.00
63_A69_Y0.6571.00
22_V28_D0.6371.00
15_R20_R0.6351.00
51_R60_C0.6331.00
65_S68_L0.6311.00
13_L17_E0.6281.00
42_A61_L0.6261.00
53_S56_D0.6251.00
13_L37_W0.6231.00
47_Q58_E0.6181.00
26_G31_V0.6181.00
43_M46_A0.6161.00
47_Q57_I0.6001.00
2_G7_S0.5991.00
8_Q12_L0.5971.00
64_H68_L0.5961.00
55_R58_E0.5901.00
65_S69_Y0.5881.00
59_A63_A0.5691.00
50_G56_D0.5631.00
5_V8_Q0.5501.00
60_C68_L0.5461.00
33_S54_L0.5421.00
56_D60_C0.5361.00
49_T52_E0.5301.00
45_F61_L0.5261.00
14_P19_D0.5181.00
26_G36_C0.5091.00
10_L15_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mzzA 1 0.3108 4.8 0.895 Contact Map
4hrrA 1 0.9865 3.2 0.904 Contact Map
3doeB 1 0.4054 3.1 0.905 Contact Map
1vzmA 1 0.4189 3.1 0.905 Contact Map
5agaA 4 1 2.7 0.907 Contact Map
4jrbA 1 0.8784 2.7 0.907 Contact Map
1q8hA 2 0.3649 2.4 0.91 Contact Map
3g46A 2 0.9865 2.1 0.913 Contact Map
3qxlA 1 0.9865 2.1 0.913 Contact Map
2v6eA 2 1 2 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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