GREMLIN Database
DUF4369 - Domain of unknown function (DUF4369)
PFAM: PF14289 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (97)
Sequences: 24420 (20024)
Seq/√Len: 2033.1
META: 0.919

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_F53_G3.8761.00
16_G49_F3.3131.00
13_T50_S2.6771.00
17_T48_K2.6371.00
42_A51_F2.4051.00
15_K50_S2.2731.00
98_E101_L2.2541.00
17_T84_T2.1291.00
13_T52_K2.0861.00
26_V43_K1.9851.00
15_K80_K1.9701.00
15_K82_T1.9001.00
13_T80_K1.8051.00
82_T94_T1.7941.00
25_T43_K1.7721.00
77_E98_E1.7071.00
97_K100_D1.6361.00
18_I85_G1.6331.00
84_T92_K1.6261.00
97_K101_L1.5501.00
19_K86_D1.5371.00
86_D89_D1.5351.00
15_K48_K1.4741.00
42_A49_F1.4721.00
29_L64_R1.4601.00
73_P76_L1.4211.00
72_I91_A1.3781.00
96_S99_N1.3451.00
76_L79_G1.3141.00
61_Y76_L1.2711.00
26_V41_S1.2271.00
11_G52_K1.1911.00
85_G91_A1.1801.00
81_I85_G1.1471.00
85_G90_L1.1401.00
19_K84_T1.1241.00
62_Y73_P1.1071.00
75_F98_E1.0971.00
44_V49_F1.0671.00
30_K37_V1.0631.00
11_G54_K1.0561.00
29_L38_V1.0551.00
60_F64_R1.0421.00
5_C8_K1.0411.00
29_L32_D1.0411.00
53_G76_L1.0341.00
84_T94_T1.0311.00
20_G86_D1.0091.00
81_I96_S0.9811.00
30_K39_I0.9751.00
96_S100_D0.9621.00
28_L40_D0.9591.00
29_L33_G0.9591.00
82_T85_G0.9491.00
60_F73_P0.9251.00
75_F99_N0.9051.00
21_L24_G0.9041.00
30_K59_G0.9021.00
30_K33_G0.8961.00
77_E96_S0.8871.00
37_V40_D0.8831.00
11_G78_N0.8751.00
25_T41_S0.8711.00
77_E81_I0.8691.00
10_N54_K0.8571.00
74_F99_N0.8551.00
91_A99_N0.8411.00
59_G62_Y0.8291.00
41_S51_F0.8261.00
94_T100_D0.8141.00
27_Y41_S0.8121.00
21_L44_V0.8091.00
40_D43_K0.8091.00
13_T16_G0.8041.00
26_V29_L0.8041.00
25_T66_D0.8011.00
87_A90_L0.7941.00
8_K11_G0.7861.00
14_I81_I0.7861.00
12_F55_V0.7801.00
6_C9_K0.7771.00
27_Y40_D0.7711.00
38_V41_S0.7671.00
95_G99_N0.7601.00
22_K25_T0.7581.00
93_V96_S0.7571.00
62_Y70_G0.7531.00
31_Y36_L0.7451.00
28_L41_S0.7351.00
64_R71_Y0.7341.00
49_F85_G0.7241.00
45_K48_K0.7161.00
31_Y35_G0.7131.00
62_Y71_Y0.7101.00
79_G96_S0.7081.00
93_V99_N0.7061.00
60_F66_D0.6981.00
16_G44_V0.6931.00
12_F76_L0.6911.00
33_G36_L0.6911.00
32_D37_V0.6891.00
66_D70_G0.6881.00
74_F83_I0.6871.00
74_F77_E0.6801.00
7_A10_N0.6791.00
63_L66_D0.6661.00
18_I21_L0.6601.00
67_N70_G0.6521.00
7_A11_G0.6491.00
17_T82_T0.6411.00
25_T28_L0.6401.00
59_G63_L0.6231.00
86_D91_A0.6141.00
24_G28_L0.6071.00
29_L36_L0.6041.00
32_D36_L0.5991.00
23_D43_K0.5951.00
20_G87_A0.5941.00
60_F75_F0.5931.00
19_K47_G0.5841.00
55_V59_G0.5781.00
32_D35_G0.5741.00
35_G38_V0.5691.00
10_N78_N0.5671.00
22_K44_V0.5671.00
55_V76_L0.5561.00
58_P76_L0.5551.00
24_G43_K0.5551.00
23_D45_K0.5541.00
24_G66_D0.5541.00
21_L85_G0.5471.00
11_G53_G0.5461.00
55_V58_P0.5441.00
55_V78_N0.5421.00
62_Y66_D0.5411.00
72_I76_L0.5391.00
64_R67_N0.5341.00
86_D90_L0.5301.00
61_Y65_L0.5251.00
39_I61_Y0.5231.00
20_G47_G0.5231.00
49_F84_T0.5151.00
59_G76_L0.5091.00
23_D27_Y0.5071.00
60_F65_L0.5021.00
83_I91_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4u3sB 1 0.8725 30.4 0.842 Contact Map
1uwyA 1 0.8725 10.6 0.872 Contact Map
1h8lA 1 0.8137 6.9 0.882 Contact Map
3qcwA 1 0 6.6 0.883 Contact Map
2nsmA 1 0.8137 6.1 0.885 Contact Map
4eibA 2 0.6667 6 0.885 Contact Map
3ecqA 1 0.9412 5.4 0.888 Contact Map
3w5fA 1 0.4608 5.1 0.889 Contact Map
4kdwA 1 0.8039 5 0.89 Contact Map
3uafA 2 0.8431 4.7 0.891 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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