GREMLIN Database
FKS1_dom1 - 1,3-beta-glucan synthase subunit FKS1, domain-1
PFAM: PF14288 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 103 (101)
Sequences: 758 (384)
Seq/√Len: 38.2
META: 0.253

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_L56_I5.2621.00
22_M25_C3.2881.00
16_A56_I2.9341.00
63_I87_F2.8451.00
90_L96_C2.5701.00
93_S96_C2.0130.99
42_Q45_L1.9560.98
27_C92_W1.8840.98
28_F32_C1.8250.98
41_L44_R1.7880.97
13_W78_H1.7700.97
12_I51_F1.6880.96
73_G80_A1.6410.95
20_R24_E1.6020.95
85_D88_N1.5950.95
94_P100_L1.5430.94
39_S42_Q1.5220.93
17_A57_T1.5050.93
22_M87_F1.5040.93
10_L19_L1.4890.92
24_E27_C1.4850.92
10_L13_W1.4580.92
27_C31_H1.4520.91
14_G52_L1.4510.91
64_R67_E1.4510.91
33_M83_N1.4190.90
40_E45_L1.4060.90
8_L83_N1.3940.90
66_Q70_I1.3920.90
98_E101_G1.3720.89
49_G57_T1.3480.88
40_E44_R1.3380.88
52_L60_Y1.3250.87
47_P54_N1.2700.85
33_M36_Y1.2390.83
39_S44_R1.2320.83
42_Q46_E1.2010.81
14_G92_W1.1760.80
52_L55_V1.1690.79
12_I17_A1.1190.76
10_L14_G1.1100.76
18_N89_E1.0980.75
78_H82_R1.0970.75
47_P53_D1.0960.75
21_F81_W1.0920.75
40_E43_G1.0910.74
62_V82_R1.0780.74
48_E90_L1.0700.73
64_R68_Y1.0480.71
83_N89_E1.0450.71
5_Q21_F1.0280.70
23_P30_F1.0060.68
71_S74_G1.0050.68
9_Y12_I1.0050.68
49_G54_N0.9870.67
22_M63_I0.9860.67
6_I62_V0.9730.66
13_W16_A0.9720.66
34_A37_L0.9710.65
57_T70_I0.9540.64
60_Y91_F0.9470.64
14_G91_F0.9300.62
2_R101_G0.9230.62
41_L45_L0.9210.61
78_H91_F0.9130.61
77_D100_L0.8930.59
32_C96_C0.8800.58
94_P99_R0.8740.57
2_R34_A0.8610.56
26_L66_Q0.8520.55
8_L33_M0.8430.55
43_G46_E0.8390.54
16_A26_L0.8370.54
50_S54_N0.8290.53
78_H92_W0.8240.53
2_R22_M0.8240.53
62_V83_N0.8050.51
15_E20_R0.8040.51
78_H83_N0.8030.51
53_D57_T0.8010.51
66_Q87_F0.7900.50
23_P27_C0.7880.50
17_A89_E0.7810.49
69_E73_G0.7780.49
90_L97_F0.7700.48
3_L57_T0.7690.48
25_C100_L0.7590.47
83_N96_C0.7570.47
71_S76_A0.7530.46
14_G78_H0.7490.46
13_W52_L0.7450.46
12_I26_L0.7440.46
7_A77_D0.7430.46
10_L52_L0.7330.45
33_M82_R0.7290.44
10_L25_C0.7230.44
97_F102_W0.7200.44
65_D68_Y0.7150.43
14_G27_C0.7050.42
12_I78_H0.6990.42
89_E102_W0.6960.41
41_L46_E0.6870.41
32_C83_N0.6820.40
86_D91_F0.6700.39
24_E28_F0.6660.39
78_H84_Y0.6560.38
9_Y96_C0.6520.38
73_G76_A0.6510.38
68_Y75_E0.6500.38
21_F83_N0.6500.38
25_C29_I0.6450.37
40_E46_E0.6450.37
10_L60_Y0.6370.36
8_L12_I0.6330.36
81_W89_E0.6090.34
93_S98_E0.6020.34
4_L101_G0.6010.34
3_L11_L0.5920.33
4_L7_A0.5920.33
11_L18_N0.5910.33
37_L53_D0.5880.32
30_F34_A0.5880.32
26_L69_E0.5850.32
23_P33_M0.5830.32
9_Y16_A0.5820.32
25_C28_F0.5810.32
17_A38_N0.5780.32
19_L61_R0.5720.31
20_R23_P0.5720.31
12_I96_C0.5670.31
95_E101_G0.5660.31
17_A77_D0.5630.31
21_F25_C0.5550.30
13_W91_F0.5530.30
31_H89_E0.5420.29
24_E31_H0.5390.29
44_R47_P0.5360.29
17_A97_F0.5350.28
36_Y81_W0.5310.28
41_L51_F0.5280.28
62_V89_E0.5270.28
92_W96_C0.5260.28
2_R49_G0.5260.28
22_M38_N0.5250.28
50_S71_S0.5220.28
49_G53_D0.5140.27
50_S53_D0.5120.27
32_C35_D0.5080.27
21_F29_I0.5040.26
2_R46_E0.5030.26
82_R87_F0.5020.26
56_I93_S0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2msxA 1 0.6311 29.2 0.926 Contact Map
2k6xA 1 0.4369 4.4 0.95 Contact Map
2ezvA 3 0.6214 3.1 0.953 Contact Map
2mgxA 1 0.5437 2.4 0.956 Contact Map
3qx3A 2 0.6408 2.3 0.956 Contact Map
3k9fC 1 0.8641 2.2 0.957 Contact Map
3fakA 1 0.6505 2.1 0.957 Contact Map
4gfhA 2 0.8447 1.9 0.958 Contact Map
3m4iA 2 0.7864 1.9 0.958 Contact Map
4khaA 1 0.3301 1.8 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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