GREMLIN Database
DUF4368 - Domain of unknown function (DUF4368)
PFAM: PF14287 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 67 (65)
Sequences: 6728 (4649)
Seq/√Len: 576.6
META: 0.96

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_H57_D3.1211.00
41_V57_D2.8171.00
25_I32_M2.7271.00
30_P34_N2.6061.00
45_A52_R2.5021.00
57_D65_K2.4851.00
41_V59_Y2.4651.00
39_K59_Y2.3661.00
43_H55_K2.2281.00
21_K35_E1.9561.00
46_E49_D1.8721.00
48_S51_K1.8271.00
33_L37_I1.6331.00
63_I66_F1.4501.00
15_F19_V1.4461.00
46_E55_K1.4351.00
31_E35_E1.3991.00
29_T32_M1.2801.00
11_N14_K1.2491.00
12_A16_I1.2331.00
46_E53_T1.2311.00
59_Y65_K1.2041.00
19_V36_L1.1631.00
62_F65_K1.1571.00
45_A54_Q1.1271.00
14_K18_L1.1261.00
22_Y32_M1.0971.00
22_Y35_E1.0971.00
38_D61_N1.0701.00
47_K52_R1.0671.00
7_E11_N0.9901.00
10_D14_K0.9791.00
16_I20_R0.9571.00
10_D13_D0.9541.00
42_V56_I0.9511.00
47_K50_G0.9151.00
8_D11_N0.9141.00
3_E6_E0.8991.00
45_A53_T0.8961.00
48_S53_T0.8901.00
4_E8_D0.8631.00
6_E9_S0.8211.00
47_K51_K0.8181.00
37_I58_I0.8171.00
28_L40_I0.8151.00
5_F8_D0.7971.00
55_K65_K0.7851.00
49_D53_T0.7741.00
24_D27_E0.7731.00
4_E7_E0.7721.00
54_Q60_Y0.7591.00
62_F66_F0.7541.00
18_L35_E0.7481.00
19_V23_T0.7421.00
18_L62_F0.7371.00
28_L33_L0.7261.00
38_D64_G0.7101.00
5_F9_S0.7061.00
13_D17_E0.6931.00
23_T60_Y0.6811.00
31_E34_N0.6731.00
45_A48_S0.6651.00
43_H54_Q0.6631.00
60_Y66_F0.6591.00
3_E7_E0.6541.00
40_I58_I0.6451.00
8_D12_A0.6391.00
19_V64_G0.6381.00
6_E10_D0.6361.00
5_F31_E0.6341.00
15_F36_L0.6321.00
38_D59_Y0.6291.00
17_E20_R0.6241.00
37_I42_V0.6151.00
56_I59_Y0.6041.00
25_I29_T0.6021.00
43_H56_I0.5991.00
44_E52_R0.5630.99
50_G53_T0.5620.99
22_Y25_I0.5550.99
5_F12_A0.5540.99
28_L32_M0.5510.99
3_E9_S0.5490.99
45_A49_D0.5430.99
29_T36_L0.5410.99
35_E61_N0.5400.99
20_R23_T0.5250.99
46_E51_K0.5240.99
13_D16_I0.5220.99
32_M36_L0.5210.99
12_A22_Y0.5180.99
15_F34_N0.5170.99
43_H59_Y0.5130.99
21_K47_K0.5100.99
15_F54_Q0.5080.99
54_Q61_N0.5030.99
44_E56_I0.5030.99
7_E10_D0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kisA 2 0.8358 38.5 0.805 Contact Map
1vq8E 1 0.6418 9.3 0.854 Contact Map
4a17E 1 0.6866 5.7 0.868 Contact Map
3fx7A 2 0.7761 4.8 0.873 Contact Map
3j61H 1 0.7313 4.7 0.873 Contact Map
2fh5A 3 0.7612 4.6 0.873 Contact Map
4ujqK 1 0.7313 4.4 0.874 Contact Map
4mtnA 1 0.8209 3.6 0.88 Contact Map
3zf7y 1 0.7313 3.5 0.881 Contact Map
3evyA 1 0 3.2 0.883 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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