GREMLIN Database
PcfJ - PcfJ-like protein
PFAM: PF14284 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (162)
Sequences: 2684 (2182)
Seq/√Len: 171.4
META: 0.89

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
141_R145_N3.1161.00
90_G98_G2.8541.00
94_H144_C2.7431.00
121_K124_E2.5781.00
80_P115_F2.5781.00
28_K32_D2.5261.00
97_V128_T2.2521.00
116_L129_I2.2131.00
30_A33_R2.1461.00
97_V113_I2.0181.00
86_L103_Y1.9861.00
92_A125_P1.9831.00
130_E139_Q1.9541.00
104_D108_K1.9411.00
80_P86_L1.9391.00
95_H128_T1.9371.00
78_R85_E1.9271.00
86_L113_I1.8851.00
8_M35_V1.8711.00
76_I122_P1.8611.00
75_Y126_F1.8591.00
94_H143_K1.7731.00
26_D29_K1.7121.00
45_E49_E1.6991.00
111_S130_E1.6671.00
72_D160_K1.6461.00
41_K45_E1.6291.00
93_L143_K1.6251.00
105_R110_E1.5981.00
44_K48_E1.5461.00
81_K85_E1.5441.00
8_M32_D1.5331.00
89_E128_T1.5061.00
12_L38_Y1.5021.00
118_K126_F1.4971.00
39_N42_K1.4901.00
155_I159_N1.4681.00
90_G97_V1.4681.00
89_E117_R1.4631.00
88_E92_A1.4491.00
89_E115_F1.4461.00
35_V39_N1.4321.00
47_A50_I1.4301.00
11_K38_Y1.4271.00
76_I119_K1.4251.00
8_M34_L1.3951.00
46_R49_E1.3781.00
142_G146_K1.3771.00
89_E95_H1.3711.00
84_E88_E1.3671.00
78_R81_K1.3521.00
39_N91_K1.3421.00
77_I114_L1.3261.00
74_G119_K1.3081.00
38_Y42_K1.2981.00
71_E119_K1.2811.00
43_E46_R1.2761.00
75_Y116_L1.2601.00
48_E52_K1.2471.00
143_K146_K1.2241.00
118_K121_K1.2081.00
161_W165_I1.2081.00
32_D35_V1.2051.00
131_V162_A1.1941.00
8_M11_K1.1911.00
89_E97_V1.1911.00
129_I140_C1.1801.00
5_Y9_L1.1801.00
11_K42_K1.1741.00
4_D31_H1.1581.00
8_M12_L1.1491.00
132_S138_V1.1471.00
5_Y30_A1.1361.00
9_L21_Y1.1351.00
93_L125_P1.1141.00
30_A34_L1.1031.00
159_N162_A1.1001.00
19_P22_L1.0951.00
95_H142_G1.0951.00
79_V114_L1.0771.00
148_P151_H1.0751.00
95_H125_P1.0631.00
58_E62_K1.0480.99
142_G148_P1.0460.99
36_K39_N1.0420.99
50_I54_A1.0220.99
46_R50_I1.0220.99
83_V103_Y1.0110.99
87_I98_G0.9980.99
106_V112_L0.9960.99
8_M38_Y0.9910.99
45_E48_E0.9890.99
90_G95_H0.9880.99
80_P106_V0.9860.99
129_I158_V0.9830.99
5_Y34_L0.9780.99
127_Y154_I0.9750.99
82_S85_E0.9720.99
15_D18_N0.9700.99
12_L34_L0.9500.99
29_K33_R0.9450.99
34_L37_K0.9450.99
140_C158_V0.9440.99
74_G153_E0.9410.99
78_R115_F0.9310.99
131_V161_W0.9280.99
130_E138_V0.9250.99
141_R147_N0.9230.99
18_N21_Y0.9220.99
9_L14_K0.9150.99
2_W27_L0.9140.99
11_K41_K0.9140.99
116_L127_Y0.9110.99
7_D11_K0.9100.99
70_F157_F0.8980.98
53_K56_E0.8980.98
42_K46_R0.8870.98
24_P30_A0.8770.98
105_R111_S0.8580.98
12_L41_K0.8550.98
127_Y140_C0.8380.97
74_G118_K0.8320.97
77_I157_F0.8270.97
48_E51_K0.8200.97
86_L106_V0.8170.97
118_K123_D0.8150.97
38_Y41_K0.8140.97
127_Y142_G0.8040.97
33_R37_K0.8020.97
86_L93_L0.7910.96
87_I91_K0.7880.96
58_E61_F0.7850.96
80_P85_E0.7790.96
114_L131_V0.7660.96
116_L154_I0.7620.96
157_F161_W0.7620.96
70_F77_I0.7580.95
85_E88_E0.7570.95
156_K160_K0.7540.95
105_R130_E0.7540.95
126_F154_I0.7510.95
117_R122_P0.7500.95
14_K37_K0.7450.95
141_R146_K0.7430.95
57_D61_F0.7420.95
93_L144_C0.7420.95
47_A51_K0.7380.95
95_H141_R0.7270.94
96_C102_Y0.7270.94
71_E76_I0.7230.94
152_E156_K0.7180.94
49_E52_K0.7170.94
89_E93_L0.7100.94
14_K34_L0.7090.94
50_I53_K0.7040.93
61_F64_L0.6980.93
150_Y153_E0.6960.93
156_K159_N0.6930.93
158_V162_A0.6890.93
60_R64_L0.6820.92
127_Y151_H0.6790.92
41_K44_K0.6780.92
148_P158_V0.6750.92
129_I161_W0.6700.91
31_H35_V0.6700.91
7_D10_E0.6690.91
6_L10_E0.6690.91
51_K55_K0.6680.91
132_S135_G0.6560.91
62_K84_E0.6540.90
79_V106_V0.6540.90
4_D8_M0.6530.90
65_K81_K0.6460.90
10_E13_G0.6430.90
39_N43_E0.6400.90
110_E134_D0.6390.89
129_I137_V0.6340.89
152_E155_I0.6340.89
72_D75_Y0.6340.89
2_W16_L0.6300.89
106_V113_I0.6300.89
103_Y106_V0.6300.89
80_P93_L0.6280.89
43_E47_A0.6280.89
151_H154_I0.6280.89
8_M27_L0.6260.88
117_R128_T0.6200.88
60_R63_E0.6180.88
78_R117_R0.6180.88
86_L116_L0.6160.88
12_L37_K0.6080.87
77_I116_L0.6060.87
76_I79_V0.6050.87
116_L157_F0.6050.87
151_H155_I0.6020.87
34_L38_Y0.6000.86
49_E53_K0.5950.86
155_I158_V0.5940.86
115_F122_P0.5910.86
83_V86_L0.5900.85
111_S138_V0.5900.85
88_E125_P0.5890.85
140_C148_P0.5830.85
127_Y141_R0.5800.84
127_Y148_P0.5800.84
110_E132_S0.5790.84
138_V141_R0.5780.84
6_L16_L0.5750.84
43_E87_I0.5740.84
154_I161_W0.5650.83
132_S136_K0.5560.82
27_L30_A0.5550.82
115_F128_T0.5520.81
140_C154_I0.5450.81
136_K162_A0.5390.80
26_D30_A0.5390.80
72_D157_F0.5380.80
14_K21_Y0.5360.80
37_K40_A0.5340.79
20_K25_K0.5320.79
106_V111_S0.5320.79
80_P113_I0.5310.79
46_R104_D0.5300.79
161_W164_L0.5270.78
112_L133_L0.5240.78
69_E76_I0.5240.78
131_V136_K0.5230.78
9_L16_L0.5220.78
20_K94_H0.5200.77
42_K45_E0.5190.77
38_Y45_E0.5170.77
57_D60_R0.5160.77
127_Y146_K0.5150.77
98_G103_Y0.5150.77
95_H145_N0.5140.77
9_L15_D0.5140.77
40_A43_E0.5090.76
142_G154_I0.5090.76
53_K112_L0.5080.76
69_E79_V0.5050.75
14_K18_N0.5050.75
148_P152_E0.5030.75
2_W79_V0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3s1sA 1 0.3964 11.8 0.929 Contact Map
3doaA 1 0.4556 6.5 0.937 Contact Map
4ys0A 1 0.3254 4.6 0.941 Contact Map
2kw6A 2 0.3195 4.1 0.942 Contact Map
2yggA 1 0.1598 2.7 0.948 Contact Map
2m1lA 2 0.284 2.6 0.948 Contact Map
3ci9A 5 0.1302 2.6 0.948 Contact Map
2jrbA 1 0.3254 2.1 0.95 Contact Map
2qfaB 1 0.1302 1.9 0.951 Contact Map
4nkjA 3 0.2604 1.9 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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