GREMLIN Database
DUF4363 - Domain of unknown function (DUF4363)
PFAM: PF14276 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (119)
Sequences: 2197 (1985)
Seq/√Len: 182.0
META: 0.832

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_D45_E3.6371.00
82_R98_E3.5761.00
86_Y97_A3.1591.00
43_W90_E2.9361.00
53_L80_L2.7371.00
54_E84_K2.7241.00
91_D94_E2.6891.00
38_I95_A2.3751.00
34_I53_L2.3681.00
79_S98_E2.3361.00
72_E108_H2.2531.00
82_R101_E2.1981.00
10_I14_I2.1091.00
61_K77_E2.1001.00
32_E103_K2.0311.00
33_E49_E1.9531.00
37_A49_E1.8901.00
76_I102_L1.8891.00
94_E97_A1.8621.00
87_I95_A1.8371.00
43_W46_A1.8291.00
41_E92_K1.8061.00
49_E52_E1.6891.00
78_T101_E1.6771.00
35_E103_K1.6551.00
51_E84_K1.6321.00
75_E78_T1.6221.00
30_L56_K1.4841.00
37_A42_D1.4621.00
11_G15_F1.4261.00
35_E100_A1.4231.00
12_L16_S1.4051.00
84_K88_E1.3701.00
14_I18_N1.3501.00
15_F19_Y1.3251.00
45_E49_E1.2891.00
47_E88_E1.2741.00
47_E51_E1.2721.00
17_Q115_L1.2511.00
37_A45_E1.2421.00
31_L102_L1.1531.00
26_E56_K1.1501.00
28_S32_E1.1061.00
16_S67_F1.1031.00
9_L13_S1.0781.00
57_W77_E1.0451.00
83_L99_L1.0160.99
27_L76_I1.0060.99
47_E90_E0.9990.99
35_E99_L0.9810.99
34_I49_E0.9780.99
111_E118_E0.9730.99
23_S60_K0.9710.99
30_L49_E0.9580.99
30_L52_E0.9540.99
60_K64_L0.9500.99
100_A103_K0.9430.99
17_Q20_L0.9430.99
44_E47_E0.9430.99
16_S63_Y0.9350.99
73_I77_E0.9320.99
30_L33_E0.9230.99
61_K118_E0.9220.99
107_E111_E0.9220.99
76_I106_L0.9210.99
21_N25_D0.9130.99
62_K118_E0.9070.99
15_F18_N0.9000.99
57_W80_L0.8950.99
29_E32_E0.8940.99
79_S101_E0.8870.99
70_H74_D0.8790.98
83_L95_A0.8780.98
36_E39_E0.8720.98
98_E101_E0.8350.98
31_L53_L0.8250.98
86_Y91_D0.8220.98
64_L67_F0.8130.97
26_E30_L0.8060.97
16_S113_E0.7980.97
86_Y98_E0.7980.97
27_L106_L0.7920.97
10_I13_S0.7820.97
18_N22_K0.7820.97
74_D108_H0.7810.97
35_E96_L0.7770.97
46_A87_I0.7740.97
36_E40_N0.7740.97
85_A89_A0.7660.96
48_E52_E0.7650.96
64_L70_H0.7590.96
39_E96_L0.7570.96
76_I105_L0.7480.96
13_S16_S0.7470.96
23_S64_L0.7340.95
28_S103_K0.7290.95
21_N114_K0.7270.95
21_N110_P0.7260.95
64_L68_I0.7180.95
86_Y93_D0.7140.95
80_L102_L0.7120.95
54_E58_E0.7110.95
45_E48_E0.7110.95
85_A100_A0.7100.95
5_L13_S0.7070.94
50_L87_I0.7040.94
81_A104_E0.7030.94
52_E55_E0.7010.94
33_E36_E0.6970.94
6_L10_I0.6960.94
35_E39_E0.6950.94
50_L77_E0.6900.94
14_I17_Q0.6870.94
20_L68_I0.6830.93
66_I74_D0.6660.92
72_E112_K0.6620.92
57_W76_I0.6590.92
41_E44_E0.6570.92
19_Y63_Y0.6570.92
34_I95_A0.6540.92
20_L74_D0.6500.92
50_L102_L0.6490.91
66_I70_H0.6440.91
24_T106_L0.6390.91
40_N44_E0.6340.90
19_Y67_F0.6330.90
95_A99_L0.6310.90
13_S17_Q0.6310.90
20_L110_P0.6240.90
50_L84_K0.6210.90
89_A93_D0.6200.89
60_K63_Y0.6170.89
4_I7_A0.6150.89
75_E105_L0.6130.89
38_I43_W0.6120.89
86_Y95_A0.6120.89
92_K96_L0.6110.89
37_A46_A0.6050.88
99_L103_K0.6050.88
89_A96_L0.6030.88
19_Y23_S0.5950.88
98_E105_L0.5930.87
82_R86_Y0.5790.86
78_T105_L0.5760.86
32_E35_E0.5730.86
34_I38_I0.5720.85
31_L77_E0.5710.85
111_E114_K0.5710.85
48_E51_E0.5680.85
53_L76_I0.5680.85
40_N52_E0.5650.85
13_S64_L0.5640.85
79_S102_L0.5610.84
15_F22_K0.5590.84
79_S83_L0.5550.84
84_K100_A0.5530.83
61_K73_I0.5500.83
7_A11_G0.5480.83
82_R97_A0.5430.82
38_I99_L0.5420.82
29_E55_E0.5390.82
47_E84_K0.5390.82
69_D112_K0.5380.82
61_K65_S0.5370.82
69_D75_E0.5350.81
12_L15_F0.5340.81
110_P114_K0.5300.81
29_E33_E0.5290.81
53_L103_K0.5290.81
31_L103_K0.5280.81
24_T110_P0.5270.80
30_L53_L0.5240.80
4_I11_G0.5230.80
86_Y94_E0.5140.79
65_S108_H0.5090.78
16_S19_Y0.5090.78
29_E36_E0.5030.77
16_S20_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3u8pA 1 0.9833 59.6 0.819 Contact Map
4jkvA 2 0.85 35.4 0.844 Contact Map
2kc7A 1 0.775 29.8 0.849 Contact Map
4qinA 2 1 20.8 0.86 Contact Map
3n71A 1 0.9417 19.4 0.863 Contact Map
2f95B 2 0.1333 17.7 0.865 Contact Map
2f93B 2 0.1333 14.9 0.869 Contact Map
3rfyA 2 1 12.7 0.873 Contact Map
4wuyA 1 0.9417 11.8 0.875 Contact Map
4cq4A 4 0.675 11.6 0.875 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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