GREMLIN Database
DUF4360 - Domain of unknown function (DUF4360)
PFAM: PF14273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 178 (176)
Sequences: 1548 (1201)
Seq/√Len: 90.5
META: 0.708

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_Y143_T5.1641.00
88_A158_I4.1641.00
70_A128_L3.9721.00
68_T131_S3.6951.00
81_S114_D3.1851.00
83_P156_S3.0191.00
54_N142_N2.7861.00
56_Q95_Y2.7091.00
31_F165_G2.5741.00
80_A88_A2.5731.00
91_R104_S2.4471.00
20_A33_V2.3881.00
79_F114_D2.2241.00
75_D120_T2.1541.00
95_Y140_N2.1121.00
35_F163_T2.1021.00
80_A113_L2.0511.00
19_T37_Q2.0411.00
94_Y121_D2.0301.00
4_T62_H1.9871.00
76_Y94_Y1.9841.00
67_F126_A1.9761.00
86_A156_S1.9261.00
97_Q137_R1.7631.00
70_A130_W1.7601.00
68_T176_R1.7361.00
73_S120_T1.7361.00
52_R144_E1.7281.00
67_F177_R1.7111.00
42_A147_V1.5941.00
12_G15_C1.5851.00
91_R106_S1.5601.00
148_T154_A1.5561.00
77_R162_S1.5391.00
89_T106_S1.5281.00
62_H136_D1.5271.00
130_W176_R1.5121.00
65_Q175_W1.5111.00
46_A50_D1.4861.00
58_N138_N1.4741.00
87_T110_T1.4030.99
83_P86_A1.3930.99
80_A158_I1.3750.99
82_L147_V1.3410.99
69_Y173_L1.3260.99
73_S122_T1.3220.99
150_S154_A1.3150.99
56_Q142_N1.2990.99
148_T152_S1.2810.99
93_E102_T1.2780.99
33_V57_L1.2730.99
40_A147_V1.2520.98
25_S30_A1.2480.98
13_S39_L1.2390.98
58_N140_N1.2350.98
6_D60_P1.2260.98
169_T172_H1.2150.98
80_A109_F1.2130.98
77_R164_D1.2090.98
109_F119_I1.2070.98
82_L86_A1.2050.98
10_Y20_A1.1970.98
5_I8_V1.1960.98
68_T127_S1.1930.98
117_Y159_T1.1900.98
60_P138_N1.1530.97
16_P37_Q1.1420.97
11_N17_A1.1420.97
77_R116_D1.1360.97
25_S32_T1.1260.97
151_N154_A1.1160.97
63_V66_G1.1150.97
87_T108_T1.1050.97
48_P51_D1.0910.96
34_L75_D1.0870.96
145_L158_I1.0590.96
47_G50_D1.0540.95
56_Q140_N1.0490.95
89_T108_T1.0460.95
43_G46_A1.0400.95
24_V28_N1.0220.95
96_F132_P1.0180.95
90_Q119_I1.0160.94
75_D118_Q1.0130.94
32_T164_D1.0080.94
170_V173_L0.9940.94
65_Q174_Q0.9870.94
59_L141_I0.9810.93
148_T151_N0.9780.93
58_N97_Q0.9710.93
93_E144_E0.9690.93
30_A34_L0.9540.92
107_H121_D0.9490.92
44_P150_S0.9430.92
11_N36_D0.9410.92
161_D164_D0.9350.92
90_Q107_H0.9270.91
9_T23_A0.9230.91
34_L162_S0.9140.91
24_V31_F0.9050.90
32_T162_S0.8980.90
78_G117_Y0.8910.90
97_Q138_N0.8900.90
40_A51_D0.8860.89
22_V33_V0.8830.89
62_H128_L0.8820.89
69_Y130_W0.8810.89
174_Q177_R0.8750.89
52_R98_G0.8670.88
10_Y17_A0.8640.88
69_Y175_W0.8620.88
83_P154_A0.8620.88
15_C55_C0.8540.88
86_A147_V0.8530.87
92_A141_I0.8520.87
84_A110_T0.8520.87
91_R144_E0.8480.87
77_R161_D0.8440.87
25_S29_T0.8390.87
7_V59_L0.8370.86
52_R142_N0.8230.86
74_A123_L0.8220.85
6_D62_H0.8180.85
93_E104_S0.8090.85
41_Q50_D0.8070.84
3_I7_V0.8030.84
130_W133_C0.8020.84
36_D116_D0.8020.84
22_V31_F0.7980.84
105_F123_L0.7940.83
64_P94_Y0.7910.83
170_V174_Q0.7830.83
27_D76_Y0.7800.82
79_F161_D0.7790.82
173_L178_C0.7740.82
90_Q137_R0.7700.82
71_I175_W0.7660.81
148_T155_T0.7660.81
81_S115_D0.7660.81
32_T161_D0.7560.80
19_T57_L0.7530.80
175_W178_C0.7530.80
95_Y142_N0.7500.80
129_V135_A0.7400.79
12_G55_C0.7360.79
53_K140_N0.7330.78
11_N34_L0.7310.78
69_Y132_P0.7260.78
82_L156_S0.7240.77
36_D161_D0.7030.75
9_T21_S0.7030.75
16_P19_T0.7020.75
65_Q126_A0.7020.75
89_T146_R0.7010.75
43_G52_R0.6980.75
57_L167_I0.6970.75
67_F70_A0.6960.75
51_D147_V0.6930.74
60_P136_D0.6910.74
52_R95_Y0.6900.74
11_N58_N0.6900.74
50_D53_K0.6840.73
11_N16_P0.6840.73
128_L176_R0.6840.73
34_L164_D0.6820.73
109_F168_T0.6810.73
74_A94_Y0.6670.71
7_V60_P0.6660.71
63_V77_R0.6650.71
67_F133_C0.6650.71
82_L88_A0.6640.71
35_F79_F0.6620.71
8_V31_F0.6610.71
82_L111_G0.6550.70
96_F131_S0.6530.70
52_R146_R0.6450.69
125_V166_S0.6440.69
47_G87_T0.6440.69
116_D161_D0.6430.69
46_A51_D0.6430.69
130_W174_Q0.6410.68
160_M163_T0.6350.68
56_Q141_I0.6340.68
92_A96_F0.6310.67
30_A164_D0.6300.67
45_G48_P0.6270.67
123_L127_S0.6250.66
42_A150_S0.6230.66
75_D164_D0.6220.66
9_T58_N0.6210.66
42_A156_S0.6210.66
25_S52_R0.6190.66
13_S54_N0.6180.66
73_S100_S0.6160.65
145_L160_M0.6140.65
44_P154_A0.6140.65
40_A52_R0.6120.65
10_Y21_S0.6080.64
149_S152_S0.6070.64
52_R97_Q0.6070.64
147_V156_S0.6010.63
90_Q165_G0.5990.63
32_T75_D0.5980.63
44_P147_V0.5980.63
44_P148_T0.5970.63
107_H119_I0.5970.63
79_F157_F0.5940.63
39_L159_T0.5940.63
55_C178_C0.5900.62
57_L89_T0.5900.62
92_A121_D0.5870.62
96_F127_S0.5830.61
116_D144_E0.5820.61
64_P175_W0.5790.61
166_S177_R0.5790.61
21_S34_L0.5750.60
23_A30_A0.5730.60
54_N140_N0.5720.60
152_S168_T0.5690.59
10_Y34_L0.5680.59
57_L163_T0.5670.59
32_T79_F0.5600.58
165_G168_T0.5570.58
93_E142_N0.5570.58
99_S131_S0.5510.57
95_Y98_G0.5460.56
84_A104_S0.5430.56
159_T168_T0.5420.56
27_D30_A0.5410.55
71_I111_G0.5390.55
99_S132_P0.5380.55
23_A61_V0.5380.55
60_P93_E0.5340.55
73_S168_T0.5320.54
23_A34_L0.5310.54
43_G144_E0.5310.54
13_S89_T0.5290.54
10_Y36_D0.5290.54
157_F161_D0.5280.54
38_Y42_A0.5280.54
62_H65_Q0.5270.54
41_Q155_T0.5260.53
105_F119_I0.5220.53
21_S36_D0.5210.53
152_S177_R0.5200.53
156_S160_M0.5190.52
68_T130_W0.5180.52
22_V28_N0.5170.52
27_D77_R0.5170.52
76_Y121_D0.5160.52
67_F112_P0.5130.52
32_T77_R0.5120.51
44_P152_S0.5110.51
70_A131_S0.5100.51
74_A141_I0.5090.51
40_A158_I0.5090.51
21_S26_P0.5060.51
42_A83_P0.5050.51
131_S135_A0.5050.51
70_A94_Y0.5040.50
88_A116_D0.5020.50
58_N144_E0.5010.50
93_E97_Q0.5000.50
117_Y160_M0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pkmA 2 0.9438 7.3 0.939 Contact Map
1ic9A 1 0.1517 6.6 0.94 Contact Map
2lc4A 1 0.2079 3.8 0.946 Contact Map
1w3fA 4 0.6461 2.9 0.949 Contact Map
4a41A 1 0.4438 2.2 0.952 Contact Map
4b9pA 1 0.7978 1.9 0.954 Contact Map
2ag4A 1 0.309 1.7 0.956 Contact Map
3h3iA 1 0.3933 1.5 0.957 Contact Map
4ca9A 5 0.382 1.5 0.957 Contact Map
4tv4A 3 0.3258 1.5 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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