GREMLIN Database
DUF4359 - Domain of unknown function (DUF4359)
PFAM: PF14271 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (95)
Sequences: 1169 (947)
Seq/√Len: 97.1
META: 0.83

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_L93_F5.3381.00
13_Y76_T2.8841.00
66_Q75_T2.5691.00
9_S12_D2.4541.00
16_F96_F2.3181.00
65_R74_Y2.2261.00
65_R72_S2.2141.00
3_L92_I2.1921.00
74_Y96_F2.1701.00
13_Y74_Y2.0721.00
13_Y63_T2.0451.00
89_T98_T2.0421.00
4_A69_G1.9081.00
13_Y96_F1.8461.00
66_Q73_I1.8181.00
14_E60_D1.8011.00
6_T94_G1.7731.00
63_T76_T1.6731.00
10_K14_E1.6701.00
7_N65_R1.6431.00
74_Y89_T1.6051.00
92_I97_F1.5741.00
30_C44_C1.5641.00
35_N38_G1.5461.00
7_N74_Y1.5131.00
63_T74_Y1.4591.00
16_F98_T1.4421.00
90_L99_L1.4341.00
15_E19_E1.4321.00
7_N72_S1.3990.99
47_L50_S1.3610.99
46_S50_S1.3150.99
26_K49_A1.2920.99
13_Y89_T1.2680.99
89_T96_F1.2580.99
13_Y16_F1.2500.99
34_P37_L1.1800.98
42_S45_K1.1760.98
16_F74_Y1.1670.98
17_A21_L1.1240.98
19_E52_G1.1030.97
4_A7_N1.0720.97
58_L62_N1.0640.97
15_E95_N1.0560.96
42_S91_G1.0410.96
66_Q69_G1.0310.96
75_T79_G1.0010.95
25_L28_E0.9940.95
68_Y71_F0.9840.95
16_F63_T0.9760.94
75_T88_V0.9460.93
43_N46_S0.9450.93
7_N63_T0.9180.92
17_A28_E0.9010.92
28_E53_P0.8710.90
88_V96_F0.8690.90
17_A65_R0.8660.90
44_C47_L0.8630.90
12_D15_E0.8500.89
63_T96_F0.8110.87
45_K49_A0.7980.86
11_E24_Y0.7870.85
41_Q45_K0.7800.85
22_T67_N0.7780.84
10_K65_R0.7640.83
62_N73_I0.7460.82
74_Y78_L0.7410.81
2_A57_S0.7370.81
10_K61_N0.7370.81
51_G56_E0.7320.81
74_Y88_V0.7270.80
5_L42_S0.7230.80
77_E85_Y0.7210.80
40_L43_N0.7050.78
53_P56_E0.6990.77
12_D38_G0.6930.77
9_S67_N0.6890.76
2_A23_E0.6850.76
8_P91_G0.6810.76
42_S50_S0.6740.75
3_L69_G0.6730.75
51_G79_G0.6710.75
51_G54_L0.6600.73
65_R73_I0.6580.73
14_E17_A0.6560.73
80_G88_V0.6560.73
25_L48_V0.6500.72
10_K60_D0.6500.72
29_L58_L0.6480.72
67_N72_S0.6450.72
4_A67_N0.6420.71
30_C34_P0.6410.71
88_V100_D0.6390.71
4_A34_P0.6320.70
20_Q24_Y0.6320.70
75_T81_E0.6240.69
12_D31_E0.6240.69
27_E100_D0.6210.69
24_Y27_E0.6140.68
17_A72_S0.6130.68
20_Q57_S0.6080.67
26_K46_S0.6070.67
29_L33_T0.6020.66
31_E60_D0.5990.66
7_N89_T0.5990.66
7_N17_A0.5940.65
90_L96_F0.5940.65
13_Y93_F0.5910.65
94_G99_L0.5910.65
21_L78_L0.5830.64
70_L98_T0.5810.64
24_Y49_A0.5780.63
80_G97_F0.5780.63
77_E92_I0.5760.63
87_V94_G0.5750.63
19_E32_K0.5700.62
5_L21_L0.5610.61
70_L73_I0.5590.61
25_L95_N0.5580.61
22_T77_E0.5560.60
13_Y56_E0.5560.60
13_Y88_V0.5540.60
68_Y73_I0.5540.60
5_L67_N0.5480.59
65_R96_F0.5470.59
63_T88_V0.5450.59
23_E40_L0.5440.59
36_I71_F0.5390.58
15_E86_K0.5390.58
46_S70_L0.5330.57
32_K100_D0.5320.57
11_E31_E0.5320.57
20_Q60_D0.5320.57
25_L58_L0.5290.57
17_A27_E0.5290.57
9_S81_E0.5230.56
28_E34_P0.5190.55
61_N64_E0.5170.55
4_A75_T0.5170.55
42_S90_L0.5150.55
55_I73_I0.5060.53
71_F90_L0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rp4A 4 0.5446 11 0.894 Contact Map
1h6qA 1 0.8416 7.2 0.903 Contact Map
1wixA 1 0.4356 6.7 0.904 Contact Map
1yz1A 1 0.8416 5.8 0.907 Contact Map
1txjA 1 0.8416 5.1 0.909 Contact Map
1lshA 1 0.9307 4.6 0.911 Contact Map
2kg4A 1 0.4257 3.9 0.914 Contact Map
4cgyA 1 0.7129 3.8 0.915 Contact Map
2iueA 1 0.4554 3.6 0.916 Contact Map
1wy6A 1 0.6634 3.6 0.916 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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