GREMLIN Database
DUF4358 - Domain of unknown function (DUF4358)
PFAM: PF14270 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 102 (95)
Sequences: 2358 (2049)
Seq/√Len: 210.2
META: 0.855

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_E49_K3.2661.00
44_E66_R2.8041.00
60_K92_T2.7771.00
60_K64_E2.1601.00
50_A59_V2.0401.00
43_D84_K2.0351.00
30_D49_K1.9861.00
71_K86_E1.8521.00
55_D58_A1.8151.00
91_V98_A1.7421.00
27_D55_D1.7111.00
48_F59_V1.6951.00
29_E51_K1.6261.00
50_A56_A1.6161.00
56_A92_T1.5851.00
24_D27_D1.5721.00
81_Q84_K1.5581.00
13_D16_Y1.5551.00
68_E72_E1.5451.00
52_D55_D1.5391.00
61_E65_A1.5031.00
33_V46_A1.5031.00
57_E61_E1.5011.00
28_V31_Y1.4831.00
49_K95_N1.4521.00
48_F63_L1.4311.00
67_I88_A1.4071.00
42_A81_Q1.3881.00
53_E95_N1.3781.00
27_D58_A1.3741.00
40_A78_L1.3501.00
67_I71_K1.3211.00
11_E34_Y1.2671.00
82_Y86_E1.2631.00
18_E24_D1.2561.00
83_A86_E1.2501.00
21_Y33_V1.2141.00
68_E71_K1.2121.00
70_Q85_L1.2111.00
71_K85_L1.2061.00
21_Y46_A1.1991.00
47_V98_A1.1751.00
46_A63_L1.1741.00
64_E68_E1.1731.00
83_A87_N1.1641.00
28_V48_F1.1401.00
71_K82_Y1.1391.00
49_K96_Y1.1371.00
85_L101_V1.1251.00
57_E60_K1.1131.00
56_A97_V1.0931.00
69_D73_S1.0591.00
51_K55_D1.0541.00
44_E70_Q1.0461.00
61_E64_E1.0331.00
63_L99_L1.0321.00
72_E75_E1.0121.00
27_D62_A1.0071.00
70_Q73_S0.9911.00
65_A68_E0.9851.00
67_I99_L0.9751.00
12_L33_V0.9450.99
12_L16_Y0.9390.99
14_A31_Y0.9230.99
17_L31_Y0.9200.99
74_F78_L0.9140.99
58_A61_E0.9040.99
74_F85_L0.8940.99
64_E67_I0.8930.99
53_E56_A0.8870.99
50_A95_N0.8830.99
23_I62_A0.8770.99
73_S76_G0.8630.99
70_Q74_F0.8570.99
71_K75_E0.8530.99
63_L90_V0.8310.99
40_A81_Q0.8220.99
66_R70_Q0.8180.98
65_A69_D0.8150.98
75_E82_Y0.8040.98
75_E86_E0.7950.98
78_L81_Q0.7700.98
67_I85_L0.7630.98
59_V97_V0.7560.97
70_Q101_V0.7550.97
50_A97_V0.7400.97
28_V47_V0.7180.97
21_Y44_E0.7080.96
12_L35_Y0.6970.96
63_L97_V0.6950.96
15_D19_D0.6850.96
46_A99_L0.6830.95
22_G65_A0.6760.95
43_D101_V0.6570.94
42_A101_V0.6520.94
41_T78_L0.6470.94
73_S78_L0.6470.94
17_L21_Y0.6470.94
38_S74_F0.6420.94
42_A74_F0.6410.94
28_V55_D0.6310.93
92_T97_V0.6220.93
53_E57_E0.6190.92
36_S41_T0.6070.92
23_I28_V0.6070.92
38_S41_T0.6070.92
67_I90_V0.6010.91
54_D57_E0.5960.91
43_D85_L0.5910.91
90_V100_V0.5870.90
63_L100_V0.5870.90
18_E22_G0.5870.90
36_S39_G0.5780.90
56_A95_N0.5720.89
10_M37_M0.5580.88
74_F81_Q0.5560.88
56_A60_K0.5520.87
40_A77_Y0.5440.87
60_K90_V0.5410.86
90_V97_V0.5380.86
41_T84_K0.5380.86
85_L88_A0.5340.86
52_D56_A0.5330.86
42_A84_K0.5320.86
37_M40_A0.5320.86
22_G53_E0.5300.85
10_M19_D0.5270.85
17_L25_A0.5250.85
57_E92_T0.5230.85
80_E83_A0.5200.84
16_Y19_D0.5190.84
90_V99_L0.5170.84
98_A101_V0.5160.84
36_S43_D0.5160.84
96_Y99_L0.5140.84
79_P82_Y0.5140.84
31_Y48_F0.5130.83
10_M16_Y0.5090.83
33_V44_E0.5050.82
67_I70_Q0.5040.82
27_D30_D0.5040.82
50_A54_D0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgwB 1 0.6765 6.8 0.884 Contact Map
1jmtA 1 0.7451 5.3 0.89 Contact Map
2x8rA 1 0.6569 3.7 0.898 Contact Map
4m77A 1 0.6176 3.7 0.898 Contact Map
1q9uA 2 0.549 3.1 0.902 Contact Map
4m7dA 1 0.6275 3.1 0.902 Contact Map
2hgmA 1 0.8137 3 0.903 Contact Map
3p04A 2 0.6078 2.7 0.905 Contact Map
1jfxA 1 0.6667 2.7 0.905 Contact Map
4f7uA 1 0.6863 2.7 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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