GREMLIN Database
DUF4357 - Domain of unknown function (DUF4357)
PFAM: PF14267 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (54)
Sequences: 7559 (5706)
Seq/√Len: 776.5
META: 0.916

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_A40_A3.3501.00
9_V23_Y2.5641.00
11_V20_T2.3791.00
9_V21_K2.3301.00
13_E18_V2.2271.00
40_A45_E2.1611.00
36_L40_A2.1531.00
48_D52_K2.0911.00
19_F35_V2.0901.00
3_K7_D2.0861.00
19_F23_Y1.9191.00
27_S30_A1.8331.00
29_S42_G1.7071.00
2_E6_E1.6651.00
25_F34_V1.5091.00
36_L45_E1.4421.00
5_I17_L1.3601.00
28_P43_R1.3581.00
38_R45_E1.3561.00
11_V18_V1.3531.00
26_S30_A1.3341.00
41_N44_T1.1161.00
13_E16_K1.0441.00
10_L17_L1.0111.00
33_A40_A1.0061.00
10_L19_F0.9841.00
12_E17_L0.9711.00
30_A34_V0.8831.00
28_P54_L0.8831.00
12_E15_D0.8531.00
4_L34_V0.8461.00
44_T53_T0.8351.00
33_A39_S0.8171.00
8_G11_V0.8141.00
24_L36_L0.7971.00
2_E5_I0.7881.00
29_S33_A0.7861.00
19_F34_V0.7831.00
4_L9_V0.7761.00
12_E16_K0.7461.00
7_D21_K0.7341.00
1_R22_D0.7301.00
1_R17_L0.6691.00
10_L35_V0.6611.00
3_K6_E0.6581.00
32_A45_E0.6471.00
14_G18_V0.6471.00
30_A33_A0.6441.00
1_R37_G0.6391.00
32_A36_L0.6381.00
23_Y34_V0.6301.00
5_I12_E0.6291.00
21_K24_L0.6281.00
19_F25_F0.6231.00
4_L23_Y0.6201.00
4_L8_G0.6091.00
24_L35_V0.5981.00
29_S41_N0.5981.00
5_I39_S0.5931.00
28_P41_N0.5841.00
33_A38_R0.5841.00
31_A46_W0.5691.00
40_A44_T0.5611.00
30_A43_R0.5561.00
25_F30_A0.5561.00
49_K52_K0.5551.00
27_S31_A0.5541.00
22_D37_G0.5451.00
19_F22_D0.5311.00
17_L35_V0.5311.00
37_G48_D0.5301.00
38_R44_T0.5261.00
35_V46_W0.5251.00
4_L10_L0.5211.00
13_E20_T0.5191.00
36_L44_T0.5191.00
43_R54_L0.5181.00
22_D34_V0.5041.00
33_A43_R0.5041.00
24_L38_R0.5031.00
9_V19_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rf6A 1 0.7407 8.9 0.855 Contact Map
1zn6A 1 0.9259 8.9 0.856 Contact Map
3bv4A 2 0.9815 6.5 0.864 Contact Map
2yewB 4 0.963 6.2 0.865 Contact Map
3muuA 3 0.963 6.2 0.865 Contact Map
3j0fE 4 0.963 5.8 0.868 Contact Map
4yiiA 1 0.3704 5.7 0.868 Contact Map
1oh4A 1 0.5556 5.7 0.868 Contact Map
3j0cA 4 0.963 5.7 0.868 Contact Map
3t5xA 1 0.5741 5.5 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0046 seconds.