GREMLIN Database
DUF4355 - Domain of unknown function (DUF4355)
PFAM: PF14265 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 125 (122)
Sequences: 2239 (1918)
Seq/√Len: 173.7
META: 0.767

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
96_D99_E2.8141.00
58_E63_E2.7441.00
53_E57_K2.6461.00
9_V12_I2.6391.00
56_E60_E2.2711.00
57_K61_E2.2681.00
82_K108_E2.2531.00
25_E29_E2.1091.00
108_E112_N2.0641.00
61_E65_E2.0491.00
116_E120_E2.0461.00
20_E24_L1.7981.00
118_A121_E1.7501.00
6_Q10_D1.6771.00
7_E10_D1.5901.00
74_E97_A1.5651.00
111_F115_V1.5591.00
51_E56_E1.5591.00
111_F114_A1.5421.00
24_L27_E1.5141.00
45_E49_K1.4741.00
16_R19_R1.4651.00
72_K90_D1.4281.00
75_A100_T1.4041.00
42_M50_Y1.3981.00
121_E124_K1.3961.00
8_E11_K1.3741.00
50_Y54_K1.3711.00
62_L66_L1.3601.00
21_K25_E1.3581.00
24_L28_L1.3541.00
23_K27_E1.3541.00
60_E64_A1.3481.00
17_L20_E1.3401.00
20_E23_K1.3311.00
28_L31_E1.3221.00
29_E32_L1.3171.00
93_V100_T1.3161.00
15_K19_R1.2611.00
43_S46_E1.2531.00
59_L62_L1.2111.00
15_K18_A1.2041.00
53_E56_E1.1981.00
55_L59_L1.1971.00
91_F103_N1.1941.00
64_A68_R1.1891.00
49_K53_E1.1731.00
90_D106_A1.1591.00
94_G99_E1.1591.00
18_A21_K1.1551.00
57_K60_E1.1511.00
26_K30_E1.1511.00
5_T8_E1.1511.00
102_A105_E1.1461.00
52_L56_E1.1261.00
12_I16_R1.1211.00
68_R72_K1.1211.00
18_A22_K1.1121.00
5_T9_V1.0951.00
55_L58_E1.0881.00
4_F8_E1.0861.00
44_E48_A1.0831.00
87_E106_A1.0791.00
82_K105_E1.0621.00
94_G103_N1.0491.00
78_I81_E1.0420.99
109_K113_K1.0290.99
34_E37_E1.0270.99
101_K105_E1.0250.99
119_V122_R1.0180.99
54_K58_E1.0020.99
28_L32_L0.9930.99
38_K50_Y0.9700.99
16_R20_E0.9580.99
46_E49_K0.9570.99
35_E39_L0.9480.99
105_E109_K0.9460.99
35_E38_K0.9410.99
34_E38_K0.9120.99
95_E99_E0.9090.99
27_E31_E0.9020.98
50_Y53_E0.9000.98
69_R73_A0.8990.98
38_K42_M0.8980.98
11_K15_K0.8950.98
99_E103_N0.8820.98
66_L69_R0.8820.98
6_Q9_V0.8800.98
11_K14_Q0.8740.98
45_E48_A0.8680.98
62_L65_E0.8640.98
115_V119_V0.8630.98
78_I82_K0.8630.98
113_K116_E0.8600.98
3_T6_Q0.8590.98
10_D14_Q0.8530.98
21_K24_L0.8510.98
9_V13_V0.8390.98
78_I101_K0.8380.98
74_E77_K0.8360.98
92_L107_L0.8330.97
52_L55_L0.8330.97
26_K29_E0.8300.97
63_E67_A0.8250.97
14_Q18_A0.8190.97
117_K121_E0.8080.97
79_L92_L0.8070.97
66_L70_E0.8040.97
62_L69_R0.7990.97
65_E70_E0.7970.97
79_L104_I0.7910.97
37_E41_K0.7880.96
27_E30_E0.7880.96
44_E47_K0.7840.96
22_K25_E0.7830.96
33_K37_E0.7780.96
114_A118_A0.7770.96
118_A122_R0.7690.96
100_T103_N0.7610.96
37_E40_A0.7520.95
81_E101_K0.7380.95
8_E12_I0.7340.95
117_K120_E0.7340.95
80_A86_V0.7320.95
13_V16_R0.7260.94
65_E69_R0.7240.94
55_L66_L0.7240.94
13_V17_L0.7200.94
78_I104_I0.7130.94
61_E64_A0.7100.94
48_A52_L0.7100.94
76_R86_V0.7070.94
72_K76_R0.7060.94
38_K41_K0.6910.93
39_L47_K0.6770.92
115_V118_A0.6710.92
63_E66_L0.6700.92
51_E54_K0.6670.92
58_E62_L0.6650.91
62_L73_A0.6570.91
104_I108_E0.6560.91
58_E61_E0.6550.91
71_L94_G0.6490.90
39_L43_S0.6470.90
97_A101_K0.6370.90
23_K26_K0.6340.89
24_L31_E0.6330.89
5_T12_I0.6320.89
19_R23_K0.6320.89
114_A117_K0.6250.89
85_P88_L0.6200.88
6_Q16_R0.6110.88
7_E11_K0.6030.87
48_A51_E0.5970.86
54_K57_K0.5930.86
39_L97_A0.5830.85
102_A106_A0.5820.85
25_E31_E0.5820.85
91_F107_L0.5720.84
64_A95_E0.5690.84
71_L97_A0.5680.84
67_A95_E0.5660.83
62_L70_E0.5660.83
12_I17_L0.5650.83
5_T13_V0.5630.83
64_A67_A0.5620.83
49_K52_L0.5610.83
10_D19_R0.5560.82
73_A76_R0.5510.82
4_F9_V0.5460.81
92_L104_I0.5460.81
87_E113_K0.5420.81
3_T7_E0.5400.80
51_E55_L0.5400.80
100_T107_L0.5380.80
36_A39_L0.5300.79
22_K26_K0.5280.79
120_E124_K0.5260.79
99_E102_A0.5240.78
113_K117_K0.5200.78
76_R80_A0.5130.77
31_E37_E0.5040.76
82_K101_K0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dmqA 1 0.576 9.2 0.886 Contact Map
3jywX 1 0.568 5.4 0.898 Contact Map
4ujrU 1 0.568 4.8 0.9 Contact Map
1u7lA 1 0.832 3.6 0.906 Contact Map
3j39h 1 0.6 3.1 0.909 Contact Map
2bnxA 2 0.184 3.1 0.909 Contact Map
1u2mA 3 0.864 2.8 0.911 Contact Map
4w20h 1 0.592 2.7 0.912 Contact Map
4uaeA 1 0.344 2.4 0.914 Contact Map
2ll2A 1 0.072 2.3 0.915 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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