GREMLIN Database
Glucos_trans_II - Glucosyl transferase GtrII
PFAM: PF14264 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 297 (292)
Sequences: 2525 (2364)
Seq/√Len: 138.3
META: 0.74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_G140_G5.1281.00
189_Y193_Y4.2641.00
108_A145_Y4.2221.00
115_A135_L4.0171.00
169_K173_K3.3911.00
95_N101_D3.2301.00
56_A106_A2.9541.00
135_L149_F2.7831.00
101_D105_M2.6511.00
34_G137_L2.6151.00
140_G192_I2.6091.00
286_R290_G2.5391.00
62_L110_L2.5091.00
115_A149_F2.4701.00
116_V149_F2.4381.00
173_K177_K2.3891.00
132_A185_G2.3511.00
132_A136_A2.3201.00
119_L131_S2.2691.00
182_L189_Y2.2691.00
190_L194_K2.2621.00
27_W30_Q2.2191.00
214_I217_F2.2001.00
194_K198_K2.1991.00
111_L134_L2.1671.00
270_P274_N2.0911.00
267_L270_P2.0581.00
34_G141_I2.0271.00
59_L110_L2.0201.00
15_G26_Y1.9581.00
10_Y13_D1.9461.00
109_L148_V1.9281.00
95_N105_M1.9121.00
185_G189_Y1.9111.00
135_L185_G1.8851.00
48_S99_K1.8511.00
152_L156_L1.7921.00
67_L86_L1.7771.00
112_A138_S1.7611.00
11_I14_L1.7591.00
28_L36_E1.7521.00
14_L98_Y1.7271.00
3_I13_D1.6851.00
35_L104_G1.6751.00
69_R117_Y1.6731.00
251_K255_K1.6351.00
46_D99_K1.6351.00
124_K127_G1.6291.00
36_E40_K1.6241.00
253_K258_L1.6011.00
7_N10_Y1.5961.00
269_L272_A1.5961.00
215_K219_K1.5581.00
212_N215_K1.5541.00
118_L134_L1.5491.00
222_L225_L1.5251.00
96_L99_K1.5021.00
59_L103_P1.4951.00
13_D99_K1.4741.00
196_F200_F1.4731.00
122_K125_K1.4711.00
59_L63_S1.4611.00
107_L141_I1.4491.00
223_Y226_L1.4351.00
65_V69_R1.4341.00
130_L134_L1.4341.00
64_A87_V1.3961.00
68_V79_A1.3941.00
111_L137_L1.3921.00
39_S104_G1.3881.00
245_A249_R1.3871.00
9_L14_L1.3821.00
249_R253_K1.3811.00
144_A147_G1.3801.00
35_L101_D1.3791.00
35_L100_F1.3781.00
64_A71_L1.3591.00
115_A119_L1.3571.00
115_A134_L1.3571.00
66_L117_Y1.3471.00
228_L231_L1.3321.00
118_L127_G1.3111.00
67_L113_V1.3041.00
64_A83_A1.3021.00
89_F93_L1.2901.00
136_A140_G1.2871.00
214_I218_Y1.2801.00
182_L193_Y1.2661.00
7_N46_D1.2621.00
201_G206_Y1.2441.00
278_L284_R1.2431.00
35_L105_M1.2391.00
110_L114_L1.2351.00
207_L211_L1.2301.00
96_L102_A1.2251.00
282_L286_R1.2241.00
197_L200_F1.2201.00
286_R289_M1.2121.00
7_N13_D1.2101.00
156_L160_D1.2091.00
61_A65_V1.2081.00
245_A252_K1.1981.00
230_I240_L1.1971.00
224_G227_F1.1961.00
136_A192_I1.1951.00
3_I7_N1.1951.00
13_D46_D1.1861.00
211_L215_K1.1831.00
18_F21_R1.1720.99
263_L267_L1.1720.99
201_G204_L1.1710.99
224_G228_L1.1690.99
186_L190_L1.1690.99
79_A83_A1.1690.99
143_Q189_Y1.1680.99
202_I206_Y1.1600.99
63_S109_L1.1560.99
69_R74_K1.1550.99
60_L109_L1.1410.99
33_W140_G1.1390.99
84_L88_L1.1370.99
232_L236_L1.1320.99
9_L13_D1.1050.99
91_F95_N1.1030.99
225_L229_G1.1010.99
213_N217_F1.1010.99
274_N277_L1.0940.99
98_Y143_Q1.0900.99
150_I272_A1.0880.99
95_N145_Y1.0640.99
193_Y204_L1.0630.99
10_Y97_S1.0620.99
36_E39_S1.0610.99
69_R72_G1.0600.99
110_L113_V1.0580.99
115_A131_S1.0560.99
193_Y197_L1.0550.99
252_K256_K1.0490.99
253_K256_K1.0440.99
231_L234_L1.0370.99
55_L107_L1.0340.99
212_N216_R1.0250.99
127_G131_S1.0210.99
198_K202_I1.0200.99
93_L105_M1.0110.98
91_F94_E1.0090.98
4_L57_I1.0060.98
247_L256_K1.0050.98
122_K126_L1.0020.98
64_A68_V1.0020.98
73_I76_K0.9990.98
278_L282_L0.9950.98
282_L287_T0.9940.98
136_A185_G0.9890.98
167_S170_E0.9890.98
10_Y14_L0.9800.98
109_L145_Y0.9780.98
38_L107_L0.9780.98
53_G56_A0.9770.98
211_L217_F0.9760.98
271_F274_N0.9720.98
17_I20_G0.9720.98
284_R290_G0.9700.98
252_K255_K0.9670.98
94_E100_F0.9660.98
156_L159_R0.9660.98
111_L141_I0.9620.98
278_L281_P0.9600.98
38_L104_G0.9590.98
166_K172_L0.9580.98
136_A188_L0.9550.98
285_P288_L0.9540.98
59_L106_A0.9530.98
5_T8_S0.9510.98
56_A59_L0.9490.98
224_G229_G0.9450.98
191_L195_L0.9430.98
186_L189_Y0.9380.98
284_R287_T0.9330.97
253_K257_L0.9330.97
232_L250_K0.9300.97
115_A138_S0.9290.97
131_S149_F0.9220.97
292_G295_L0.9220.97
139_L186_L0.9110.97
272_A276_I0.9060.97
270_P275_L0.9030.97
182_L185_G0.9010.97
234_L238_L0.8990.97
224_G232_L0.8990.97
280_S287_T0.8980.97
31_G143_Q0.8890.97
89_F101_D0.8780.96
53_G102_A0.8770.96
287_T290_G0.8730.96
197_L204_L0.8720.96
240_L243_L0.8710.96
55_L59_L0.8690.96
211_L214_I0.8690.96
180_G183_I0.8660.96
92_F106_A0.8650.96
132_A184_L0.8640.96
251_K254_K0.8560.96
271_F278_L0.8530.96
223_Y228_L0.8520.96
226_L231_L0.8470.95
228_L232_L0.8440.95
227_F230_I0.8400.95
208_S212_N0.8390.95
208_S211_L0.8260.95
66_L110_L0.8220.95
13_D17_I0.8170.94
23_L26_Y0.8160.94
94_E97_S0.8160.94
154_L265_L0.8150.94
3_I6_N0.8090.94
166_K170_E0.8080.94
254_K257_L0.8060.94
262_L266_L0.8050.94
98_Y141_I0.8050.94
94_E98_Y0.8030.94
27_W35_L0.8030.94
268_L271_F0.8020.94
123_K126_L0.7910.93
235_L239_L0.7820.93
74_K77_L0.7790.93
11_I15_G0.7760.93
184_L195_L0.7750.93
249_R255_K0.7700.93
164_G172_L0.7650.92
272_A277_L0.7640.92
112_A135_L0.7620.92
114_L134_L0.7610.92
202_I205_S0.7600.92
284_R288_L0.7600.92
62_L66_L0.7600.92
248_I258_L0.7550.92
197_L202_I0.7540.92
190_L193_Y0.7520.92
82_A86_L0.7510.92
100_F103_P0.7410.91
207_L264_L0.7410.91
125_K132_A0.7350.91
89_F143_Q0.7340.91
229_G241_L0.7280.90
285_P291_F0.7250.90
192_I196_F0.7240.90
150_I275_L0.7180.90
58_L62_L0.7180.90
194_K240_L0.7170.90
242_L248_I0.7150.90
88_L93_L0.7140.89
231_L242_L0.7130.89
240_L244_I0.7110.89
210_I217_F0.7070.89
228_L237_L0.7060.89
207_L210_I0.7050.89
227_F232_L0.7040.89
13_D100_F0.7010.89
56_A63_S0.7000.89
223_Y236_L0.6990.88
233_L252_K0.6970.88
197_L201_G0.6970.88
53_G61_A0.6940.88
170_E173_K0.6920.88
149_F152_L0.6900.88
119_L178_Y0.6880.88
32_R143_Q0.6840.87
157_L160_D0.6820.87
111_L251_K0.6810.87
16_F19_Y0.6790.87
21_R46_D0.6780.87
33_W147_G0.6780.87
231_L241_L0.6780.87
73_I112_A0.6760.87
126_L130_L0.6750.87
226_L229_G0.6750.87
101_D104_G0.6750.87
36_E101_D0.6740.87
223_Y232_L0.6730.87
230_I233_L0.6720.86
186_L193_Y0.6720.86
180_G188_L0.6700.86
43_G59_L0.6690.86
243_L248_I0.6670.86
21_R101_D0.6660.86
250_K254_K0.6660.86
147_G150_I0.6650.86
216_R219_K0.6640.86
67_L110_L0.6640.86
152_L155_I0.6630.86
280_S286_R0.6620.86
93_L101_D0.6580.85
134_L138_S0.6570.85
227_F231_L0.6570.85
229_G235_L0.6560.85
221_F227_F0.6560.85
122_K127_G0.6530.85
71_L156_L0.6520.85
263_L266_L0.6510.85
188_L192_I0.6510.85
156_L178_Y0.6510.85
86_L92_F0.6500.85
211_L218_Y0.6500.85
163_K172_L0.6490.85
223_Y231_L0.6470.84
22_S25_G0.6450.84
234_L249_R0.6450.84
266_L269_L0.6440.84
260_L264_L0.6430.84
228_L239_L0.6430.84
9_L99_K0.6400.84
65_V68_V0.6390.84
108_A119_L0.6380.83
53_G99_K0.6370.83
213_N216_R0.6370.83
70_L117_Y0.6360.83
13_D25_G0.6360.83
237_L248_I0.6310.83
63_S110_L0.6290.83
236_L247_L0.6250.82
102_A106_A0.6250.82
229_G237_L0.6240.82
194_K197_L0.6220.82
282_L288_L0.6210.82
269_L273_L0.6200.82
27_W101_D0.6200.82
80_L83_A0.6190.82
76_K81_L0.6170.81
245_A251_K0.6170.81
231_L240_L0.6150.81
229_G232_L0.6110.81
222_L227_F0.6100.81
8_S135_L0.6090.81
67_L71_L0.6080.80
225_L228_L0.6070.80
182_L186_L0.6070.80
262_L273_L0.6070.80
227_F243_L0.5990.79
223_Y227_F0.5980.79
87_V161_L0.5960.79
270_P277_L0.5960.79
46_D57_I0.5950.79
273_L277_L0.5940.79
151_V288_L0.5940.79
164_G167_S0.5890.78
3_I10_Y0.5870.78
193_Y196_F0.5860.78
181_V185_G0.5850.78
33_W136_A0.5840.78
84_L87_V0.5800.77
254_K258_L0.5790.77
231_L245_A0.5790.77
72_G183_I0.5780.77
80_L140_G0.5770.77
100_F143_Q0.5770.77
116_V143_Q0.5760.77
41_L59_L0.5740.77
174_L177_K0.5730.76
226_L242_L0.5720.76
66_L70_L0.5710.76
16_F20_G0.5700.76
35_L95_N0.5700.76
225_L230_I0.5680.76
8_S14_L0.5680.76
125_K130_L0.5670.76
248_I253_K0.5670.76
185_G201_G0.5670.76
113_V116_V0.5650.75
265_L269_L0.5650.75
282_L289_M0.5640.75
68_V98_Y0.5630.75
50_F54_L0.5610.75
3_I99_K0.5610.75
37_L62_L0.5590.75
288_L291_F0.5590.75
39_S109_L0.5580.75
151_V154_L0.5570.74
281_P290_G0.5570.74
37_L40_K0.5560.74
89_F102_A0.5550.74
131_S151_V0.5540.74
41_L263_L0.5530.74
14_L33_W0.5530.74
203_E206_Y0.5520.74
221_F229_G0.5520.74
61_A160_D0.5460.73
29_S38_L0.5440.73
241_L245_A0.5400.72
92_F95_N0.5400.72
13_D20_G0.5390.72
63_S86_L0.5390.72
13_D103_P0.5390.72
220_I231_L0.5380.72
19_Y22_S0.5370.72
222_L226_L0.5360.72
271_F275_L0.5350.71
48_S53_G0.5330.71
39_S103_P0.5330.71
283_F287_T0.5320.71
220_I240_L0.5320.71
14_L27_W0.5300.71
33_W39_S0.5300.71
189_Y201_G0.5280.70
260_L268_L0.5280.70
103_P106_A0.5270.70
266_L270_P0.5260.70
285_P290_G0.5250.70
281_P286_R0.5230.70
131_S181_V0.5230.70
172_L191_L0.5220.70
3_I94_E0.5200.69
167_S172_L0.5190.69
155_I159_R0.5190.69
189_Y197_L0.5180.69
223_Y233_L0.5180.69
273_L276_I0.5170.69
36_E94_E0.5160.69
13_D97_S0.5150.69
240_L256_K0.5130.68
94_E286_R0.5120.68
168_L173_K0.5110.68
209_G212_N0.5100.68
14_L34_G0.5100.68
96_L143_Q0.5100.68
140_G189_Y0.5090.68
223_Y230_I0.5090.68
196_F199_I0.5090.68
232_L243_L0.5080.68
164_G168_L0.5060.67
60_L96_L0.5050.67
187_V213_N0.5050.67
133_L257_L0.5040.67
279_S286_R0.5030.67
63_S113_V0.5030.67
210_I215_K0.5020.67
70_L120_R0.5010.67
18_F27_W0.5000.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rceA 1 0.798 96.4 0.841 Contact Map
3wajA 1 0.8384 86 0.886 Contact Map
3tx3A 2 0.2593 8.2 0.941 Contact Map
3rlfF 1 0.2121 3.3 0.951 Contact Map
3dh4A 3 0.569 2.5 0.954 Contact Map
4p02B 1 0.229 2.2 0.955 Contact Map
4nv5A 1 0.3973 2 0.957 Contact Map
4pypA 1 0.4007 1.7 0.958 Contact Map
4czbA 2 0.2357 1.6 0.959 Contact Map
2l2tA 2 0.1481 1.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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