Glucos_trans_II - PFAM28P - GREMLIN Contacts

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Glucos_trans_II - Glucosyl transferase GtrII

PFAM:	PF14264	Sequences: LPILTNNSLYIDDLGFIFYGRSLYGYWLSQGRWGLELLSKLFGLYDISPFLPGLLAILLLALSAVLLVRLLGIKSKLAALLAALLLVLFPFFLENLSYKFDAPGMALALLLAVLAVYLLRKKKKKLGFLLSALLLALSLGIYQAYIGVFIVLVLILLLRDLLKGKKSLKEILKLGLKYLGVLILGLVLYLLIYKLFLKIFGIELSYLSGILNNIKRFYKIFLYGLLFLGILLLLLLLLLLLLLIALLIRKKKKKKKLLLLLLLLLLLLLPFALNLILLSSPLFRPRTLMGFGVVLVF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	297 (292)
Sequences:	2525 (2364)
Seq/√Len:	138.3
META:	0.74

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_G	140_G	5.128	1.00
189_Y	193_Y	4.264	1.00
108_A	145_Y	4.222	1.00
115_A	135_L	4.017	1.00
169_K	173_K	3.391	1.00
95_N	101_D	3.230	1.00
56_A	106_A	2.954	1.00
135_L	149_F	2.783	1.00
101_D	105_M	2.651	1.00
34_G	137_L	2.615	1.00
140_G	192_I	2.609	1.00
286_R	290_G	2.539	1.00
62_L	110_L	2.509	1.00
115_A	149_F	2.470	1.00
116_V	149_F	2.438	1.00
173_K	177_K	2.389	1.00
132_A	185_G	2.351	1.00
132_A	136_A	2.320	1.00
119_L	131_S	2.269	1.00
182_L	189_Y	2.269	1.00
190_L	194_K	2.262	1.00
27_W	30_Q	2.219	1.00
214_I	217_F	2.200	1.00
194_K	198_K	2.199	1.00
111_L	134_L	2.167	1.00
270_P	274_N	2.091	1.00
267_L	270_P	2.058	1.00
34_G	141_I	2.027	1.00
59_L	110_L	2.020	1.00
15_G	26_Y	1.958	1.00
10_Y	13_D	1.946	1.00
109_L	148_V	1.928	1.00
95_N	105_M	1.912	1.00
185_G	189_Y	1.911	1.00
135_L	185_G	1.885	1.00
48_S	99_K	1.851	1.00
152_L	156_L	1.792	1.00
67_L	86_L	1.777	1.00
112_A	138_S	1.761	1.00
11_I	14_L	1.759	1.00
28_L	36_E	1.752	1.00
14_L	98_Y	1.727	1.00
3_I	13_D	1.685	1.00
35_L	104_G	1.675	1.00
69_R	117_Y	1.673	1.00
251_K	255_K	1.635	1.00
46_D	99_K	1.635	1.00
124_K	127_G	1.629	1.00
36_E	40_K	1.624	1.00
253_K	258_L	1.601	1.00
7_N	10_Y	1.596	1.00
269_L	272_A	1.596	1.00
215_K	219_K	1.558	1.00
212_N	215_K	1.554	1.00
118_L	134_L	1.549	1.00
222_L	225_L	1.525	1.00
96_L	99_K	1.502	1.00
59_L	103_P	1.495	1.00
13_D	99_K	1.474	1.00
196_F	200_F	1.473	1.00
122_K	125_K	1.471	1.00
59_L	63_S	1.461	1.00
107_L	141_I	1.449	1.00
223_Y	226_L	1.435	1.00
65_V	69_R	1.434	1.00
130_L	134_L	1.434	1.00
64_A	87_V	1.396	1.00
68_V	79_A	1.394	1.00
111_L	137_L	1.392	1.00
39_S	104_G	1.388	1.00
245_A	249_R	1.387	1.00
9_L	14_L	1.382	1.00
249_R	253_K	1.381	1.00
144_A	147_G	1.380	1.00
35_L	101_D	1.379	1.00
35_L	100_F	1.378	1.00
64_A	71_L	1.359	1.00
115_A	119_L	1.357	1.00
115_A	134_L	1.357	1.00
66_L	117_Y	1.347	1.00
228_L	231_L	1.332	1.00
118_L	127_G	1.311	1.00
67_L	113_V	1.304	1.00
64_A	83_A	1.302	1.00
89_F	93_L	1.290	1.00
136_A	140_G	1.287	1.00
214_I	218_Y	1.280	1.00
182_L	193_Y	1.266	1.00
7_N	46_D	1.262	1.00
201_G	206_Y	1.244	1.00
278_L	284_R	1.243	1.00
35_L	105_M	1.239	1.00
110_L	114_L	1.235	1.00
207_L	211_L	1.230	1.00
96_L	102_A	1.225	1.00
282_L	286_R	1.224	1.00
197_L	200_F	1.220	1.00
286_R	289_M	1.212	1.00
7_N	13_D	1.210	1.00
156_L	160_D	1.209	1.00
61_A	65_V	1.208	1.00
245_A	252_K	1.198	1.00
230_I	240_L	1.197	1.00
224_G	227_F	1.196	1.00
136_A	192_I	1.195	1.00
3_I	7_N	1.195	1.00
13_D	46_D	1.186	1.00
211_L	215_K	1.183	1.00
18_F	21_R	1.172	0.99
263_L	267_L	1.172	0.99
201_G	204_L	1.171	0.99
224_G	228_L	1.169	0.99
186_L	190_L	1.169	0.99
79_A	83_A	1.169	0.99
143_Q	189_Y	1.168	0.99
202_I	206_Y	1.160	0.99
63_S	109_L	1.156	0.99
69_R	74_K	1.155	0.99
60_L	109_L	1.141	0.99
33_W	140_G	1.139	0.99
84_L	88_L	1.137	0.99
232_L	236_L	1.132	0.99
9_L	13_D	1.105	0.99
91_F	95_N	1.103	0.99
225_L	229_G	1.101	0.99
213_N	217_F	1.101	0.99
274_N	277_L	1.094	0.99
98_Y	143_Q	1.090	0.99
150_I	272_A	1.088	0.99
95_N	145_Y	1.064	0.99
193_Y	204_L	1.063	0.99
10_Y	97_S	1.062	0.99
36_E	39_S	1.061	0.99
69_R	72_G	1.060	0.99
110_L	113_V	1.058	0.99
115_A	131_S	1.056	0.99
193_Y	197_L	1.055	0.99
252_K	256_K	1.049	0.99
253_K	256_K	1.044	0.99
231_L	234_L	1.037	0.99
55_L	107_L	1.034	0.99
212_N	216_R	1.025	0.99
127_G	131_S	1.021	0.99
198_K	202_I	1.020	0.99
93_L	105_M	1.011	0.98
91_F	94_E	1.009	0.98
4_L	57_I	1.006	0.98
247_L	256_K	1.005	0.98
122_K	126_L	1.002	0.98
64_A	68_V	1.002	0.98
73_I	76_K	0.999	0.98
278_L	282_L	0.995	0.98
282_L	287_T	0.994	0.98
136_A	185_G	0.989	0.98
167_S	170_E	0.989	0.98
10_Y	14_L	0.980	0.98
109_L	145_Y	0.978	0.98
38_L	107_L	0.978	0.98
53_G	56_A	0.977	0.98
211_L	217_F	0.976	0.98
271_F	274_N	0.972	0.98
17_I	20_G	0.972	0.98
284_R	290_G	0.970	0.98
252_K	255_K	0.967	0.98
94_E	100_F	0.966	0.98
156_L	159_R	0.966	0.98
111_L	141_I	0.962	0.98
278_L	281_P	0.960	0.98
38_L	104_G	0.959	0.98
166_K	172_L	0.958	0.98
136_A	188_L	0.955	0.98
285_P	288_L	0.954	0.98
59_L	106_A	0.953	0.98
5_T	8_S	0.951	0.98
56_A	59_L	0.949	0.98
224_G	229_G	0.945	0.98
191_L	195_L	0.943	0.98
186_L	189_Y	0.938	0.98
284_R	287_T	0.933	0.97
253_K	257_L	0.933	0.97
232_L	250_K	0.930	0.97
115_A	138_S	0.929	0.97
131_S	149_F	0.922	0.97
292_G	295_L	0.922	0.97
139_L	186_L	0.911	0.97
272_A	276_I	0.906	0.97
270_P	275_L	0.903	0.97
182_L	185_G	0.901	0.97
234_L	238_L	0.899	0.97
224_G	232_L	0.899	0.97
280_S	287_T	0.898	0.97
31_G	143_Q	0.889	0.97
89_F	101_D	0.878	0.96
53_G	102_A	0.877	0.96
287_T	290_G	0.873	0.96
197_L	204_L	0.872	0.96
240_L	243_L	0.871	0.96
55_L	59_L	0.869	0.96
211_L	214_I	0.869	0.96
180_G	183_I	0.866	0.96
92_F	106_A	0.865	0.96
132_A	184_L	0.864	0.96
251_K	254_K	0.856	0.96
271_F	278_L	0.853	0.96
223_Y	228_L	0.852	0.96
226_L	231_L	0.847	0.95
228_L	232_L	0.844	0.95
227_F	230_I	0.840	0.95
208_S	212_N	0.839	0.95
208_S	211_L	0.826	0.95
66_L	110_L	0.822	0.95
13_D	17_I	0.817	0.94
23_L	26_Y	0.816	0.94
94_E	97_S	0.816	0.94
154_L	265_L	0.815	0.94
3_I	6_N	0.809	0.94
166_K	170_E	0.808	0.94
254_K	257_L	0.806	0.94
262_L	266_L	0.805	0.94
98_Y	141_I	0.805	0.94
94_E	98_Y	0.803	0.94
27_W	35_L	0.803	0.94
268_L	271_F	0.802	0.94
123_K	126_L	0.791	0.93
235_L	239_L	0.782	0.93
74_K	77_L	0.779	0.93
11_I	15_G	0.776	0.93
184_L	195_L	0.775	0.93
249_R	255_K	0.770	0.93
164_G	172_L	0.765	0.92
272_A	277_L	0.764	0.92
112_A	135_L	0.762	0.92
114_L	134_L	0.761	0.92
202_I	205_S	0.760	0.92
284_R	288_L	0.760	0.92
62_L	66_L	0.760	0.92
248_I	258_L	0.755	0.92
197_L	202_I	0.754	0.92
190_L	193_Y	0.752	0.92
82_A	86_L	0.751	0.92
100_F	103_P	0.741	0.91
207_L	264_L	0.741	0.91
125_K	132_A	0.735	0.91
89_F	143_Q	0.734	0.91
229_G	241_L	0.728	0.90
285_P	291_F	0.725	0.90
192_I	196_F	0.724	0.90
150_I	275_L	0.718	0.90
58_L	62_L	0.718	0.90
194_K	240_L	0.717	0.90
242_L	248_I	0.715	0.90
88_L	93_L	0.714	0.89
231_L	242_L	0.713	0.89
240_L	244_I	0.711	0.89
210_I	217_F	0.707	0.89
228_L	237_L	0.706	0.89
207_L	210_I	0.705	0.89
227_F	232_L	0.704	0.89
13_D	100_F	0.701	0.89
56_A	63_S	0.700	0.89
223_Y	236_L	0.699	0.88
233_L	252_K	0.697	0.88
197_L	201_G	0.697	0.88
53_G	61_A	0.694	0.88
170_E	173_K	0.692	0.88
149_F	152_L	0.690	0.88
119_L	178_Y	0.688	0.88
32_R	143_Q	0.684	0.87
157_L	160_D	0.682	0.87
111_L	251_K	0.681	0.87
16_F	19_Y	0.679	0.87
21_R	46_D	0.678	0.87
33_W	147_G	0.678	0.87
231_L	241_L	0.678	0.87
73_I	112_A	0.676	0.87
126_L	130_L	0.675	0.87
226_L	229_G	0.675	0.87
101_D	104_G	0.675	0.87
36_E	101_D	0.674	0.87
223_Y	232_L	0.673	0.87
230_I	233_L	0.672	0.86
186_L	193_Y	0.672	0.86
180_G	188_L	0.670	0.86
43_G	59_L	0.669	0.86
243_L	248_I	0.667	0.86
21_R	101_D	0.666	0.86
250_K	254_K	0.666	0.86
147_G	150_I	0.665	0.86
216_R	219_K	0.664	0.86
67_L	110_L	0.664	0.86
152_L	155_I	0.663	0.86
280_S	286_R	0.662	0.86
93_L	101_D	0.658	0.85
134_L	138_S	0.657	0.85
227_F	231_L	0.657	0.85
229_G	235_L	0.656	0.85
221_F	227_F	0.656	0.85
122_K	127_G	0.653	0.85
71_L	156_L	0.652	0.85
263_L	266_L	0.651	0.85
188_L	192_I	0.651	0.85
156_L	178_Y	0.651	0.85
86_L	92_F	0.650	0.85
211_L	218_Y	0.650	0.85
163_K	172_L	0.649	0.85
223_Y	231_L	0.647	0.84
22_S	25_G	0.645	0.84
234_L	249_R	0.645	0.84
266_L	269_L	0.644	0.84
260_L	264_L	0.643	0.84
228_L	239_L	0.643	0.84
9_L	99_K	0.640	0.84
65_V	68_V	0.639	0.84
108_A	119_L	0.638	0.83
53_G	99_K	0.637	0.83
213_N	216_R	0.637	0.83
70_L	117_Y	0.636	0.83
13_D	25_G	0.636	0.83
237_L	248_I	0.631	0.83
63_S	110_L	0.629	0.83
236_L	247_L	0.625	0.82
102_A	106_A	0.625	0.82
229_G	237_L	0.624	0.82
194_K	197_L	0.622	0.82
282_L	288_L	0.621	0.82
269_L	273_L	0.620	0.82
27_W	101_D	0.620	0.82
80_L	83_A	0.619	0.82
76_K	81_L	0.617	0.81
245_A	251_K	0.617	0.81
231_L	240_L	0.615	0.81
229_G	232_L	0.611	0.81
222_L	227_F	0.610	0.81
8_S	135_L	0.609	0.81
67_L	71_L	0.608	0.80
225_L	228_L	0.607	0.80
182_L	186_L	0.607	0.80
262_L	273_L	0.607	0.80
227_F	243_L	0.599	0.79
223_Y	227_F	0.598	0.79
87_V	161_L	0.596	0.79
270_P	277_L	0.596	0.79
46_D	57_I	0.595	0.79
273_L	277_L	0.594	0.79
151_V	288_L	0.594	0.79
164_G	167_S	0.589	0.78
3_I	10_Y	0.587	0.78
193_Y	196_F	0.586	0.78
181_V	185_G	0.585	0.78
33_W	136_A	0.584	0.78
84_L	87_V	0.580	0.77
254_K	258_L	0.579	0.77
231_L	245_A	0.579	0.77
72_G	183_I	0.578	0.77
80_L	140_G	0.577	0.77
100_F	143_Q	0.577	0.77
116_V	143_Q	0.576	0.77
41_L	59_L	0.574	0.77
174_L	177_K	0.573	0.76
226_L	242_L	0.572	0.76
66_L	70_L	0.571	0.76
16_F	20_G	0.570	0.76
35_L	95_N	0.570	0.76
225_L	230_I	0.568	0.76
8_S	14_L	0.568	0.76
125_K	130_L	0.567	0.76
248_I	253_K	0.567	0.76
185_G	201_G	0.567	0.76
113_V	116_V	0.565	0.75
265_L	269_L	0.565	0.75
282_L	289_M	0.564	0.75
68_V	98_Y	0.563	0.75
50_F	54_L	0.561	0.75
3_I	99_K	0.561	0.75
37_L	62_L	0.559	0.75
288_L	291_F	0.559	0.75
39_S	109_L	0.558	0.75
151_V	154_L	0.557	0.74
281_P	290_G	0.557	0.74
37_L	40_K	0.556	0.74
89_F	102_A	0.555	0.74
131_S	151_V	0.554	0.74
41_L	263_L	0.553	0.74
14_L	33_W	0.553	0.74
203_E	206_Y	0.552	0.74
221_F	229_G	0.552	0.74
61_A	160_D	0.546	0.73
29_S	38_L	0.544	0.73
241_L	245_A	0.540	0.72
92_F	95_N	0.540	0.72
13_D	20_G	0.539	0.72
63_S	86_L	0.539	0.72
13_D	103_P	0.539	0.72
220_I	231_L	0.538	0.72
19_Y	22_S	0.537	0.72
222_L	226_L	0.536	0.72
271_F	275_L	0.535	0.71
48_S	53_G	0.533	0.71
39_S	103_P	0.533	0.71
283_F	287_T	0.532	0.71
220_I	240_L	0.532	0.71
14_L	27_W	0.530	0.71
33_W	39_S	0.530	0.71
189_Y	201_G	0.528	0.70
260_L	268_L	0.528	0.70
103_P	106_A	0.527	0.70
266_L	270_P	0.526	0.70
285_P	290_G	0.525	0.70
281_P	286_R	0.523	0.70
131_S	181_V	0.523	0.70
172_L	191_L	0.522	0.70
3_I	94_E	0.520	0.69
167_S	172_L	0.519	0.69
155_I	159_R	0.519	0.69
189_Y	197_L	0.518	0.69
223_Y	233_L	0.518	0.69
273_L	276_I	0.517	0.69
36_E	94_E	0.516	0.69
13_D	97_S	0.515	0.69
240_L	256_K	0.513	0.68
94_E	286_R	0.512	0.68
168_L	173_K	0.511	0.68
209_G	212_N	0.510	0.68
14_L	34_G	0.510	0.68
96_L	143_Q	0.510	0.68
140_G	189_Y	0.509	0.68
223_Y	230_I	0.509	0.68
196_F	199_I	0.509	0.68
232_L	243_L	0.508	0.68
164_G	168_L	0.506	0.67
60_L	96_L	0.505	0.67
187_V	213_N	0.505	0.67
133_L	257_L	0.504	0.67
279_S	286_R	0.503	0.67
63_S	113_V	0.503	0.67
210_I	215_K	0.502	0.67
70_L	120_R	0.501	0.67
18_F	27_W	0.500	0.66

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3rceA	1	0.798	96.4	0.841	Contact Map
3wajA	1	0.8384	86	0.886	Contact Map
3tx3A	2	0.2593	8.2	0.941	Contact Map
3rlfF	1	0.2121	3.3	0.951	Contact Map
3dh4A	3	0.569	2.5	0.954	Contact Map
4p02B	1	0.229	2.2	0.955	Contact Map
4nv5A	1	0.3973	2	0.957	Contact Map
4pypA	1	0.4007	1.7	0.958	Contact Map
4czbA	2	0.2357	1.6	0.959	Contact Map
2l2tA	2	0.1481	1.5	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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