GREMLIN Database
DUF4351 - Domain of unknown function (DUF4351)
PFAM: PF14261 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (54)
Sequences: 11328 (8650)
Seq/√Len: 1177.1
META: 0.895

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
11_L43_A3.0651.00
18_R48_D2.7611.00
14_R44_E2.5571.00
18_R44_E2.3391.00
34_L42_L2.0941.00
35_S38_Q1.8261.00
13_L28_E1.7451.00
14_R40_E1.5611.00
15_L46_L1.5421.00
28_E32_E1.4671.00
13_L31_I1.4131.00
24_P27_V1.3981.00
4_R10_E1.3831.00
50_S54_D1.3491.00
13_L32_E1.3311.00
9_A32_E1.3301.00
17_E28_E1.2811.00
2_E6_E1.2641.00
43_A46_L1.2611.00
16_L23_L1.2421.00
8_E40_E1.2271.00
5_Q9_A1.2151.00
45_A49_A1.2001.00
41_A45_A1.1141.00
4_R7_G1.0841.00
16_L52_L1.0811.00
10_E40_E1.0781.00
17_E22_P1.0491.00
13_L17_E1.0371.00
51_S54_D1.0161.00
8_E11_L1.0131.00
12_L42_L1.0121.00
29_E33_A0.9941.00
25_P29_E0.9921.00
44_E48_D0.9781.00
15_L43_A0.9431.00
36_L40_E0.9421.00
20_F51_S0.8991.00
42_L55_L0.8811.00
25_P28_E0.8711.00
14_R18_R0.8631.00
8_E36_L0.8571.00
20_F52_L0.8541.00
49_A55_L0.8401.00
38_Q41_A0.8221.00
15_L47_L0.8021.00
22_P25_P0.7901.00
29_E32_E0.7671.00
17_E44_E0.7581.00
24_P52_L0.7541.00
12_L43_A0.7461.00
19_R50_S0.7291.00
9_A13_L0.7021.00
7_G43_A0.6941.00
11_L15_L0.6881.00
3_G7_G0.6791.00
42_L49_A0.6731.00
34_L49_A0.6361.00
8_E39_L0.6201.00
26_E29_E0.6061.00
34_L38_Q0.6061.00
4_R8_E0.5931.00
7_G11_L0.5661.00
41_A44_E0.5611.00
16_L46_L0.5571.00
45_A55_L0.5521.00
37_E40_E0.5521.00
17_E23_L0.5511.00
5_Q36_L0.5391.00
34_L45_A0.5361.00
9_A34_L0.5301.00
20_F49_A0.5281.00
3_G6_E0.5261.00
19_R40_E0.5231.00
23_L52_L0.5191.00
20_F50_S0.5171.00
16_L31_I0.5101.00
10_E13_L0.5091.00
49_A52_L0.5061.00
27_V30_R0.5061.00
18_R45_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4x86A 1 0.7119 44.4 0.766 Contact Map
1ywfA 1 0.7627 12.9 0.82 Contact Map
3mjkA 2 0.5763 9.9 0.829 Contact Map
3kyzA 2 0.5763 5.9 0.846 Contact Map
4qkoA 2 0.5593 5.8 0.847 Contact Map
4anoA 1 0.9153 5.7 0.847 Contact Map
2qnlA 2 0.9153 5.7 0.847 Contact Map
3u43A 1 0.5593 5.3 0.849 Contact Map
4xlgB 1 0.8814 5.3 0.849 Contact Map
3mjgA 2 0 5.1 0.85 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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