GREMLIN Database
YwiC - YwiC-like protein
PFAM: PF14256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (125)
Sequences: 3774 (3109)
Seq/√Len: 278.1
META: 0.891

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_L32_A3.4351.00
37_A67_L2.7801.00
54_R58_R2.6881.00
33_L71_A2.4321.00
60_W64_Y2.4261.00
107_S110_G2.0211.00
12_L36_L1.9971.00
19_L28_G1.9771.00
54_R57_A1.9711.00
37_A71_A1.9511.00
35_A121_A1.8801.00
120_L123_P1.8781.00
87_L91_P1.7911.00
37_A68_A1.7431.00
43_Q47_L1.7391.00
52_R57_A1.7261.00
56_R59_R1.7161.00
53_R57_A1.6871.00
60_W63_V1.6861.00
98_W102_R1.6731.00
10_M13_V1.6631.00
18_G22_A1.6151.00
65_G69_A1.5821.00
67_L71_A1.5821.00
41_A61_L1.5811.00
25_S28_G1.5481.00
74_A78_L1.4611.00
53_R56_R1.4511.00
26_W30_L1.4481.00
100_A105_E1.4411.00
108_L112_L1.4401.00
31_L124_A1.4081.00
4_E7_A1.3611.00
93_F96_Q1.3601.00
46_L100_A1.3571.00
50_G103_R1.3551.00
99_L110_G1.3451.00
64_Y68_A1.3421.00
119_A123_P1.3391.00
115_A119_A1.3271.00
34_A75_L1.3131.00
95_V99_L1.3081.00
30_L71_A1.3051.00
34_A38_A1.2941.00
16_L20_L1.2851.00
96_Q114_G1.2761.00
3_R43_Q1.2471.00
55_R59_R1.2461.00
30_L74_A1.2441.00
53_R59_R1.2251.00
96_Q110_G1.2231.00
17_L21_V1.2121.00
39_F42_R1.2061.00
75_L79_G1.1821.00
11_L36_L1.1671.00
86_A93_F1.1641.00
55_R58_R1.1541.00
40_L64_Y1.1441.00
43_Q46_L1.1441.00
3_R10_M1.1391.00
9_G13_V1.1251.00
38_A68_A1.1231.00
62_L66_A1.1231.00
2_P5_H1.0781.00
94_A98_W1.0741.00
59_R63_V1.0701.00
10_M14_P1.0581.00
73_A77_A1.0561.00
91_P94_A1.0301.00
111_E114_G1.0291.00
89_A120_L1.0271.00
39_F111_E1.0181.00
58_R62_L1.0031.00
105_E110_G0.9891.00
45_L61_L0.9841.00
118_L121_A0.9791.00
98_W101_A0.9711.00
63_V66_A0.9611.00
62_L65_G0.9611.00
2_P8_W0.9551.00
60_W65_G0.9261.00
48_L58_R0.9241.00
75_L78_L0.9241.00
48_L61_L0.9151.00
61_L65_G0.9031.00
34_A68_A0.9031.00
30_L33_L0.9001.00
19_L24_P0.8981.00
39_F43_Q0.8911.00
47_L57_A0.8811.00
34_A71_A0.8731.00
74_A77_A0.8701.00
99_L104_R0.8541.00
116_A120_L0.8401.00
96_Q100_A0.8361.00
114_G118_L0.8361.00
41_A45_L0.8351.00
35_A89_A0.8341.00
104_R107_S0.8311.00
85_L89_A0.8301.00
46_L51_D0.7980.99
68_A72_G0.7720.99
3_R7_A0.7690.99
111_E115_A0.7640.99
95_V98_W0.7590.99
13_V17_L0.7540.99
95_V113_A0.7540.99
121_A125_A0.7530.99
43_Q50_G0.7450.99
96_Q111_E0.7440.99
41_A44_P0.7390.99
48_L60_W0.7360.99
33_L67_L0.7190.99
24_P28_G0.7180.99
28_G125_A0.7180.99
15_L125_A0.7180.99
4_E44_P0.7160.99
26_W29_L0.7140.99
66_A70_A0.7090.98
27_A78_L0.7070.98
48_L51_D0.7060.98
52_R56_R0.7060.98
111_E118_L0.7010.98
41_A65_G0.6980.98
111_E119_A0.6940.98
20_L24_P0.6940.98
7_A43_Q0.6870.98
41_A68_A0.6840.98
83_L86_A0.6840.98
83_L89_A0.6830.98
37_A41_A0.6790.98
99_L107_S0.6760.98
10_M43_Q0.6750.98
71_A75_L0.6750.98
31_L86_A0.6730.98
93_F97_L0.6730.98
44_P114_G0.6700.98
54_R59_R0.6580.98
2_P6_G0.6560.98
56_R69_A0.6510.97
23_G28_G0.6480.97
111_E117_A0.6440.97
52_R59_R0.6340.97
3_R11_L0.6320.97
30_L78_L0.6230.97
76_L80_P0.6200.97
34_A72_G0.6160.96
90_A94_A0.6160.96
66_A101_A0.6090.96
52_R58_R0.5980.96
46_L105_E0.5940.96
116_A119_A0.5930.96
10_M20_L0.5900.95
37_A64_Y0.5850.95
28_G32_A0.5760.95
37_A40_L0.5750.95
44_P47_L0.5700.94
29_L33_L0.5660.94
18_G51_D0.5650.94
25_S29_L0.5630.94
84_W87_L0.5600.94
111_E121_A0.5560.94
47_L51_D0.5510.93
25_S30_L0.5500.93
15_L31_L0.5480.93
9_G42_R0.5470.93
1_L40_L0.5460.93
83_L87_L0.5460.93
65_G72_G0.5430.93
66_A76_L0.5390.93
56_R60_W0.5380.93
109_L113_A0.5340.92
15_L35_A0.5340.92
2_P7_A0.5280.92
42_R117_A0.5240.92
52_R55_R0.5240.92
40_L43_Q0.5220.91
27_A30_L0.5200.91
96_Q99_L0.5170.91
14_P39_F0.5090.90
7_A11_L0.5060.90
108_L121_A0.5050.90
121_A124_A0.5040.90
81_A84_W0.5040.90
9_G14_P0.5030.90
11_L118_L0.5010.90
61_L102_R0.5010.90
42_R46_L0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8968 26.9 0.886 Contact Map
3rceA 1 0.8968 12.9 0.902 Contact Map
3wajA 1 0.9365 10.9 0.905 Contact Map
1xioA 2 0.4048 6.2 0.915 Contact Map
3qapA 1 0.4048 4.7 0.92 Contact Map
2nq2A 2 0.7619 3.9 0.923 Contact Map
3giaA 1 0.8968 3.6 0.924 Contact Map
4qtnA 3 0.627 3.6 0.924 Contact Map
4p02A 1 0.7063 3.4 0.925 Contact Map
3tx3A 2 0.8175 3.2 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0055 seconds.