GREMLIN Database
Cys_rich_CPXG - Cysteine-rich CPXCG
PFAM: PF14255 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (49)
Sequences: 13808 (7347)
Seq/√Len: 1049.6
META: 0.952

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_E35_E2.7461.00
22_E37_R2.3941.00
10_I28_E2.3121.00
2_Q9_E2.1561.00
4_P34_I1.9741.00
12_I36_V1.9371.00
8_E29_V1.8921.00
20_S39_E1.8281.00
26_D31_C1.8091.00
2_Q7_G1.7541.00
25_E28_E1.7201.00
13_L28_E1.6391.00
24_V35_E1.5661.00
39_E48_S1.5421.00
5_Y34_I1.4391.00
1_V10_I1.4321.00
16_P40_V1.3321.00
5_Y32_R1.3121.00
14_V38_V1.2821.00
40_V47_V1.2301.00
10_I34_I1.2081.00
26_D33_P1.1931.00
3_C6_C1.1171.00
41_D46_E1.1111.00
42_E45_G1.0931.00
15_D18_A1.0101.00
1_V34_I0.9381.00
41_D45_G0.9361.00
15_D19_G0.9341.00
7_G25_E0.8761.00
12_I28_E0.8661.00
20_S37_R0.8421.00
14_V40_V0.8411.00
7_G32_R0.8231.00
1_V4_P0.8061.00
1_V12_I0.7781.00
10_I29_V0.7701.00
23_Y36_V0.7681.00
23_Y38_V0.7361.00
41_D48_S0.7201.00
44_G48_S0.7181.00
18_A21_Q0.7081.00
41_D44_G0.7071.00
26_D29_V0.6971.00
10_I23_Y0.6881.00
11_E28_E0.6841.00
19_G40_V0.6591.00
10_I25_E0.6571.00
40_V46_E0.6471.00
44_G47_V0.6451.00
38_V49_V0.6391.00
43_D46_E0.6381.00
13_L25_E0.6241.00
27_C30_C0.6141.00
12_I23_Y0.6101.00
38_V47_V0.6081.00
5_Y15_D0.5971.00
40_V45_G0.5841.00
8_E26_D0.5821.00
12_I21_Q0.5721.00
13_L17_S0.5681.00
1_V36_V0.5651.00
3_C27_C0.5591.00
29_V33_P0.5531.00
45_G48_S0.5521.00
1_V28_E0.5391.00
6_C27_C0.5351.00
3_C30_C0.5241.00
28_E34_I0.5201.00
42_E47_V0.5171.00
15_D25_E0.5161.00
42_E46_E0.5071.00
16_P47_V0.5031.00
16_P19_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wiiA 1 1 77.8 0.713 Contact Map
4qiwP 1 0.8077 67.1 0.736 Contact Map
1pqvS 1 0.7115 63.3 0.742 Contact Map
2lcqA 1 0.6346 62.7 0.743 Contact Map
2fiyA 1 0.9615 54.9 0.754 Contact Map
1vd4A 1 0.8269 54.4 0.755 Contact Map
3po3S 1 0.7115 53.3 0.757 Contact Map
3wwlA 1 0.8269 52.7 0.758 Contact Map
4aybP 1 0.8462 50.2 0.761 Contact Map
3h0gL 1 0.8077 49.9 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0048 seconds.