GREMLIN Database
AbiH - Bacteriophage abortive infection AbiH
PFAM: PF14253 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 267 (262)
Sequences: 2932 (2677)
Seq/√Len: 165.4
META: 0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_S20_D4.1391.00
15_K20_D4.1281.00
161_N180_K3.9051.00
154_F163_L3.8981.00
236_I239_H3.8061.00
164_E176_H3.1791.00
10_L17_S3.0811.00
3_I239_H2.9561.00
56_D59_N2.8771.00
176_H180_K2.8511.00
239_H249_F2.6931.00
251_E254_E2.6841.00
12_H167_Y2.6471.00
251_E255_H2.5181.00
10_L20_D2.4691.00
20_D23_E2.1381.00
156_N176_H2.1301.00
161_N165_K2.0711.00
54_W58_E2.0291.00
12_H162_T1.9561.00
203_Y207_F1.9141.00
91_E94_F1.8431.00
3_I252_I1.8131.00
107_E111_E1.8031.00
1_L252_I1.7791.00
25_L29_K1.7681.00
199_I207_F1.7571.00
214_I218_K1.7551.00
259_K263_W1.7241.00
209_N212_E1.7191.00
202_Y206_L1.6831.00
35_N38_F1.6471.00
201_K204_Q1.6151.00
235_Y264_F1.5931.00
59_N63_E1.5911.00
23_E26_K1.5841.00
203_Y206_L1.5451.00
190_G247_T1.5231.00
92_E95_S1.5091.00
246_R250_K1.4871.00
161_N181_L1.4591.00
123_L126_Y1.4541.00
196_Y205_N1.4281.00
24_Y28_N1.4201.00
57_F61_L1.4201.00
212_E216_N1.3991.00
211_G214_I1.3991.00
4_I8_F1.3971.00
107_E110_E1.3921.00
6_N9_D1.3831.00
95_S98_D1.3801.00
78_D81_K1.3701.00
55_S60_E1.3681.00
127_L130_W1.3661.00
205_N208_K1.3621.00
226_Y230_D1.3601.00
104_L107_E1.3511.00
224_L230_D1.3431.00
208_K212_E1.3431.00
90_D94_F1.3411.00
88_L91_E1.3381.00
150_P153_L1.3341.00
221_F224_L1.3121.00
89_K93_D1.3011.00
55_S242_G1.2981.00
126_Y129_E1.2941.00
38_F42_L1.2761.00
12_H166_L1.2731.00
194_E198_E1.2711.00
163_L176_H1.2661.00
97_S100_L1.2661.00
38_F41_F1.2651.00
120_I123_L1.2521.00
115_E126_Y1.2481.00
236_I241_L1.2441.00
44_K47_K1.2361.00
57_F187_F1.2351.00
51_G57_F1.2351.00
10_L19_S1.2331.00
96_D101_D1.2331.00
73_F76_L1.2271.00
249_F253_F1.2271.00
162_T166_L1.2191.00
198_E201_K1.2171.00
191_D246_R1.2151.00
214_I217_N1.2151.00
194_E201_K1.2061.00
250_K254_E1.2041.00
87_Y94_F1.1931.00
241_L249_F1.1871.00
108_L111_E1.1801.00
116_L126_Y1.1791.00
256_L261_I1.1741.00
36_E39_E1.1741.00
197_K201_K1.1581.00
160_T181_L1.1571.00
25_L28_N1.1561.00
96_D99_L1.1541.00
16_T162_T1.1511.00
180_K185_I1.1501.00
80_I84_L1.1461.00
126_Y130_W1.1441.00
10_L15_K1.1441.00
212_E215_K1.1441.00
220_F223_S1.1411.00
14_L162_T1.1401.00
74_D77_F1.1371.00
12_H16_T1.1371.00
18_Y21_F1.1291.00
157_F239_H1.1291.00
112_L115_E1.1291.00
157_F177_I1.1241.00
113_I116_L1.1221.00
56_D60_E1.1181.00
211_G216_N1.1171.00
199_I204_Q1.1171.00
39_E42_L1.0941.00
215_K218_K1.0931.00
261_I265_Y1.0931.00
12_H237_F1.0871.00
241_L265_Y1.0690.99
224_L229_I1.0670.99
200_E204_Q1.0670.99
209_N213_I1.0590.99
120_I126_Y1.0580.99
3_I248_Y1.0560.99
216_N219_S1.0550.99
62_G189_H1.0530.99
94_F97_S1.0500.99
246_R249_F1.0460.99
64_L68_I1.0440.99
208_K214_I1.0430.99
62_G65_L1.0390.99
204_Q207_F1.0380.99
5_G9_D1.0330.99
196_Y200_E1.0200.99
189_H241_L1.0180.99
87_Y91_E1.0140.99
194_E197_K1.0110.99
200_E205_N1.0100.99
73_F87_Y1.0030.99
253_F261_I1.0010.99
87_Y90_D0.9950.99
67_K71_D0.9940.99
83_F86_E0.9910.99
144_K147_L0.9910.99
19_S23_E0.9890.99
258_C261_I0.9850.99
8_F12_H0.9780.99
80_I83_F0.9740.99
201_K206_L0.9710.99
208_K213_I0.9700.99
261_I264_F0.9650.99
210_T213_I0.9600.99
116_L120_I0.9580.99
115_E123_L0.9580.99
35_N39_E0.9560.99
95_S99_L0.9540.99
204_Q211_G0.9490.99
116_L119_L0.9490.99
234_I252_I0.9450.99
244_S248_Y0.9390.99
60_E63_E0.9370.99
189_H237_F0.9300.99
180_K183_N0.9290.99
120_I130_W0.9260.99
128_K132_N0.9250.98
123_L130_W0.9220.98
61_L65_L0.9210.98
189_H248_Y0.9200.98
16_T134_I0.9070.98
119_L126_Y0.9070.98
234_I247_T0.9060.98
104_L109_E0.9040.98
50_E53_N0.9030.98
155_L175_I0.9030.98
3_I234_I0.9010.98
175_I220_F0.8950.98
244_S249_F0.8900.98
236_I249_F0.8890.98
196_Y207_F0.8890.98
81_K84_L0.8880.98
4_I11_A0.8830.98
62_G190_G0.8800.98
81_K87_Y0.8710.98
189_H244_S0.8680.98
199_I202_Y0.8660.98
223_S226_Y0.8630.98
73_F77_F0.8620.98
46_N49_K0.8590.98
196_Y202_Y0.8550.97
196_Y204_Q0.8540.97
108_L112_L0.8510.97
164_E167_Y0.8490.97
210_T214_I0.8470.97
18_Y187_F0.8450.97
120_I127_L0.8430.97
3_I157_F0.8420.97
248_Y256_L0.8390.97
130_W135_D0.8360.97
196_Y199_I0.8340.97
86_E90_D0.8340.97
244_S247_T0.8330.97
89_K99_L0.8330.97
130_W134_I0.8310.97
199_I203_Y0.8310.97
5_G8_F0.8310.97
214_I219_S0.8250.97
200_E203_Y0.8240.97
163_L169_I0.8220.97
124_E128_K0.8170.97
24_Y27_K0.8160.97
193_D197_K0.8100.97
37_L40_Y0.8080.96
85_E89_K0.8080.96
72_D83_F0.8080.96
119_L123_L0.8060.96
249_F256_L0.8050.96
163_L252_I0.8040.96
208_K211_G0.8020.96
94_F98_D0.8010.96
48_K60_E0.8010.96
51_G60_E0.7990.96
239_H253_F0.7990.96
164_E174_I0.7950.96
87_Y96_D0.7930.96
230_D233_I0.7910.96
154_F169_I0.7900.96
31_E34_D0.7760.96
127_L131_I0.7750.96
256_L265_Y0.7740.96
195_D198_E0.7740.96
247_T251_E0.7730.95
192_L196_Y0.7720.95
198_E202_Y0.7710.95
47_K50_E0.7630.95
59_N243_E0.7600.95
211_G217_N0.7590.95
224_L228_N0.7560.95
197_K200_E0.7540.95
17_S187_F0.7540.95
167_Y170_P0.7530.95
243_E246_R0.7510.95
217_N221_F0.7510.95
3_I249_F0.7480.95
113_I118_K0.7450.94
11_A237_F0.7400.94
258_C262_K0.7370.94
115_E118_K0.7370.94
236_I263_W0.7290.94
54_W65_L0.7270.94
202_Y210_T0.7260.94
55_S62_G0.7260.94
72_D76_L0.7240.94
157_F248_Y0.7240.94
96_D100_L0.7240.94
202_Y208_K0.7230.94
200_E207_F0.7210.93
238_G245_D0.7200.93
13_G229_I0.7180.93
61_L189_H0.7160.93
190_G196_Y0.7150.93
193_D196_Y0.7150.93
257_N261_I0.7150.93
94_F99_L0.7140.93
143_K149_L0.7140.93
60_E64_L0.7100.93
171_K180_K0.7030.93
62_G243_E0.7020.93
93_D97_S0.7010.92
192_L195_D0.6920.92
177_I234_I0.6900.92
36_E40_Y0.6850.92
101_D106_E0.6840.92
33_Y39_E0.6810.91
67_K72_D0.6790.91
124_E130_W0.6790.91
79_D83_F0.6780.91
97_S107_E0.6780.91
211_G215_K0.6770.91
208_K217_N0.6770.91
223_S233_I0.6760.91
155_L177_I0.6750.91
239_H242_G0.6750.91
219_S222_K0.6740.91
207_F210_T0.6730.91
92_E96_D0.6670.91
10_L13_G0.6660.90
155_L248_Y0.6650.90
241_L247_T0.6610.90
234_I248_Y0.6600.90
237_F249_F0.6590.90
4_I154_F0.6590.90
202_Y207_F0.6580.90
2_Y55_S0.6560.90
2_Y61_L0.6530.90
220_F226_Y0.6480.89
228_N231_E0.6470.89
201_K205_N0.6400.89
131_I134_I0.6400.89
62_G244_S0.6390.89
196_Y206_L0.6380.89
196_Y203_Y0.6360.88
163_L167_Y0.6350.88
34_D38_F0.6340.88
190_G207_F0.6330.88
77_F81_K0.6310.88
91_E98_D0.6240.87
190_G248_Y0.6230.87
119_L127_L0.6170.87
134_I137_S0.6160.87
104_L111_E0.6110.86
145_K148_D0.6100.86
123_L127_L0.6100.86
107_E123_L0.6080.86
108_L118_K0.6060.86
153_L156_N0.6030.86
195_D200_E0.6020.85
192_L203_Y0.6020.85
197_K204_Q0.5980.85
141_K145_K0.5980.85
248_Y258_C0.5960.85
217_N224_L0.5940.85
155_L220_F0.5920.85
120_I124_E0.5870.84
119_L130_W0.5860.84
80_I87_Y0.5820.84
197_K205_N0.5810.83
100_L103_K0.5800.83
41_F179_G0.5800.83
66_K69_D0.5800.83
253_F256_L0.5780.83
62_G242_G0.5770.83
76_L80_I0.5740.83
10_L187_F0.5730.83
108_L115_E0.5710.82
127_L133_K0.5710.82
122_E126_Y0.5710.82
226_Y233_I0.5670.82
206_L209_N0.5670.82
86_E89_K0.5630.82
48_K51_G0.5630.82
89_K92_E0.5620.81
13_G237_F0.5620.81
96_D104_L0.5610.81
10_L16_T0.5600.81
105_I108_L0.5600.81
21_F57_F0.5590.81
240_S245_D0.5570.81
221_F251_E0.5570.81
242_G246_R0.5550.81
244_S254_E0.5520.80
119_L124_E0.5500.80
94_F100_L0.5470.80
259_K262_K0.5450.79
175_I217_N0.5420.79
116_L123_L0.5400.79
178_H252_I0.5400.79
117_D124_E0.5400.79
135_D149_L0.5390.79
62_G249_F0.5390.79
1_L18_Y0.5380.79
209_N215_K0.5380.79
125_E128_K0.5370.78
194_E199_I0.5350.78
20_D186_I0.5330.78
256_L259_K0.5330.78
180_K184_N0.5330.78
85_E88_L0.5320.78
45_I49_K0.5300.77
239_H246_R0.5290.77
14_L134_I0.5280.77
84_L88_L0.5270.77
125_E129_E0.5250.77
80_I92_E0.5200.76
222_K225_N0.5200.76
221_F233_I0.5190.76
246_R254_E0.5190.76
98_D101_D0.5180.76
76_L79_D0.5170.76
10_L22_I0.5170.76
95_S101_D0.5160.76
127_L134_I0.5150.75
153_L173_N0.5140.75
57_F244_S0.5140.75
112_L119_L0.5110.75
243_E250_K0.5040.74
4_I156_N0.5040.74
61_L187_F0.5030.74
229_I233_I0.5010.74
23_E27_K0.5010.74
45_I177_I0.5010.74
22_I55_S0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l8kA 1 0.1498 12.1 0.95 Contact Map
1ex9A 1 0.3521 6.1 0.956 Contact Map
2b6hA 2 0.2247 3.5 0.961 Contact Map
1z08A 2 0.2135 3.3 0.961 Contact Map
3x1lB 1 0.2247 3.1 0.962 Contact Map
1z06A 1 0.2022 3.1 0.962 Contact Map
1r2qA 1 0.2135 3.1 0.962 Contact Map
3ds8A 1 0.3408 3 0.962 Contact Map
2gf9A 1 0.2247 3 0.962 Contact Map
3pqcA 1 0.2247 2.9 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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