AbiH - PFAM28P - GREMLIN Contacts

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AbiH - Bacteriophage abortive infection AbiH

PFAM:	PF14253	Sequences: LYIIGNGFDLAHGLKTSYSDFIEYLKKNKKEIYDNELFEYFLKKINKKKEGENWSDFENELGELLKKIDKDDFDELFDDIKDFLEEYLKDEEDFSDSDLLDEKLIEELEEELINELDKLIEELEEYLKEWINKIDISKISKKKKKKLDLPNDLFLNFNYTNTLEKLYGIPKENIIHIHGKLDNNIIFGHGDLDEDYKEIEKYYQNLFKNTGEIIKNNKSFFKSLNYRNIDEFIIYIFGHSLGESDRTYFKEIFEHLNCKSIKWFYYY	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	267 (262)
Sequences:	2932 (2677)
Seq/√Len:	165.4
META:	0.787

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_S	20_D	4.139	1.00
15_K	20_D	4.128	1.00
161_N	180_K	3.905	1.00
154_F	163_L	3.898	1.00
236_I	239_H	3.806	1.00
164_E	176_H	3.179	1.00
10_L	17_S	3.081	1.00
3_I	239_H	2.956	1.00
56_D	59_N	2.877	1.00
176_H	180_K	2.851	1.00
239_H	249_F	2.693	1.00
251_E	254_E	2.684	1.00
12_H	167_Y	2.647	1.00
251_E	255_H	2.518	1.00
10_L	20_D	2.469	1.00
20_D	23_E	2.138	1.00
156_N	176_H	2.130	1.00
161_N	165_K	2.071	1.00
54_W	58_E	2.029	1.00
12_H	162_T	1.956	1.00
203_Y	207_F	1.914	1.00
91_E	94_F	1.843	1.00
3_I	252_I	1.813	1.00
107_E	111_E	1.803	1.00
1_L	252_I	1.779	1.00
25_L	29_K	1.768	1.00
199_I	207_F	1.757	1.00
214_I	218_K	1.755	1.00
259_K	263_W	1.724	1.00
209_N	212_E	1.719	1.00
202_Y	206_L	1.683	1.00
35_N	38_F	1.647	1.00
201_K	204_Q	1.615	1.00
235_Y	264_F	1.593	1.00
59_N	63_E	1.591	1.00
23_E	26_K	1.584	1.00
203_Y	206_L	1.545	1.00
190_G	247_T	1.523	1.00
92_E	95_S	1.509	1.00
246_R	250_K	1.487	1.00
161_N	181_L	1.459	1.00
123_L	126_Y	1.454	1.00
196_Y	205_N	1.428	1.00
24_Y	28_N	1.420	1.00
57_F	61_L	1.420	1.00
212_E	216_N	1.399	1.00
211_G	214_I	1.399	1.00
4_I	8_F	1.397	1.00
107_E	110_E	1.392	1.00
6_N	9_D	1.383	1.00
95_S	98_D	1.380	1.00
78_D	81_K	1.370	1.00
55_S	60_E	1.368	1.00
127_L	130_W	1.366	1.00
205_N	208_K	1.362	1.00
226_Y	230_D	1.360	1.00
104_L	107_E	1.351	1.00
224_L	230_D	1.343	1.00
208_K	212_E	1.343	1.00
90_D	94_F	1.341	1.00
88_L	91_E	1.338	1.00
150_P	153_L	1.334	1.00
221_F	224_L	1.312	1.00
89_K	93_D	1.301	1.00
55_S	242_G	1.298	1.00
126_Y	129_E	1.294	1.00
38_F	42_L	1.276	1.00
12_H	166_L	1.273	1.00
194_E	198_E	1.271	1.00
163_L	176_H	1.266	1.00
97_S	100_L	1.266	1.00
38_F	41_F	1.265	1.00
120_I	123_L	1.252	1.00
115_E	126_Y	1.248	1.00
236_I	241_L	1.244	1.00
44_K	47_K	1.236	1.00
57_F	187_F	1.235	1.00
51_G	57_F	1.235	1.00
10_L	19_S	1.233	1.00
96_D	101_D	1.233	1.00
73_F	76_L	1.227	1.00
249_F	253_F	1.227	1.00
162_T	166_L	1.219	1.00
198_E	201_K	1.217	1.00
191_D	246_R	1.215	1.00
214_I	217_N	1.215	1.00
194_E	201_K	1.206	1.00
250_K	254_E	1.204	1.00
87_Y	94_F	1.193	1.00
241_L	249_F	1.187	1.00
108_L	111_E	1.180	1.00
116_L	126_Y	1.179	1.00
256_L	261_I	1.174	1.00
36_E	39_E	1.174	1.00
197_K	201_K	1.158	1.00
160_T	181_L	1.157	1.00
25_L	28_N	1.156	1.00
96_D	99_L	1.154	1.00
16_T	162_T	1.151	1.00
180_K	185_I	1.150	1.00
80_I	84_L	1.146	1.00
126_Y	130_W	1.144	1.00
10_L	15_K	1.144	1.00
212_E	215_K	1.144	1.00
220_F	223_S	1.141	1.00
14_L	162_T	1.140	1.00
74_D	77_F	1.137	1.00
12_H	16_T	1.137	1.00
18_Y	21_F	1.129	1.00
157_F	239_H	1.129	1.00
112_L	115_E	1.129	1.00
157_F	177_I	1.124	1.00
113_I	116_L	1.122	1.00
56_D	60_E	1.118	1.00
211_G	216_N	1.117	1.00
199_I	204_Q	1.117	1.00
39_E	42_L	1.094	1.00
215_K	218_K	1.093	1.00
261_I	265_Y	1.093	1.00
12_H	237_F	1.087	1.00
241_L	265_Y	1.069	0.99
224_L	229_I	1.067	0.99
200_E	204_Q	1.067	0.99
209_N	213_I	1.059	0.99
120_I	126_Y	1.058	0.99
3_I	248_Y	1.056	0.99
216_N	219_S	1.055	0.99
62_G	189_H	1.053	0.99
94_F	97_S	1.050	0.99
246_R	249_F	1.046	0.99
64_L	68_I	1.044	0.99
208_K	214_I	1.043	0.99
62_G	65_L	1.039	0.99
204_Q	207_F	1.038	0.99
5_G	9_D	1.033	0.99
196_Y	200_E	1.020	0.99
189_H	241_L	1.018	0.99
87_Y	91_E	1.014	0.99
194_E	197_K	1.011	0.99
200_E	205_N	1.010	0.99
73_F	87_Y	1.003	0.99
253_F	261_I	1.001	0.99
87_Y	90_D	0.995	0.99
67_K	71_D	0.994	0.99
83_F	86_E	0.991	0.99
144_K	147_L	0.991	0.99
19_S	23_E	0.989	0.99
258_C	261_I	0.985	0.99
8_F	12_H	0.978	0.99
80_I	83_F	0.974	0.99
201_K	206_L	0.971	0.99
208_K	213_I	0.970	0.99
261_I	264_F	0.965	0.99
210_T	213_I	0.960	0.99
116_L	120_I	0.958	0.99
115_E	123_L	0.958	0.99
35_N	39_E	0.956	0.99
95_S	99_L	0.954	0.99
204_Q	211_G	0.949	0.99
116_L	119_L	0.949	0.99
234_I	252_I	0.945	0.99
244_S	248_Y	0.939	0.99
60_E	63_E	0.937	0.99
189_H	237_F	0.930	0.99
180_K	183_N	0.929	0.99
120_I	130_W	0.926	0.99
128_K	132_N	0.925	0.98
123_L	130_W	0.922	0.98
61_L	65_L	0.921	0.98
189_H	248_Y	0.920	0.98
16_T	134_I	0.907	0.98
119_L	126_Y	0.907	0.98
234_I	247_T	0.906	0.98
104_L	109_E	0.904	0.98
50_E	53_N	0.903	0.98
155_L	175_I	0.903	0.98
3_I	234_I	0.901	0.98
175_I	220_F	0.895	0.98
244_S	249_F	0.890	0.98
236_I	249_F	0.889	0.98
196_Y	207_F	0.889	0.98
81_K	84_L	0.888	0.98
4_I	11_A	0.883	0.98
62_G	190_G	0.880	0.98
81_K	87_Y	0.871	0.98
189_H	244_S	0.868	0.98
199_I	202_Y	0.866	0.98
223_S	226_Y	0.863	0.98
73_F	77_F	0.862	0.98
46_N	49_K	0.859	0.98
196_Y	202_Y	0.855	0.97
196_Y	204_Q	0.854	0.97
108_L	112_L	0.851	0.97
164_E	167_Y	0.849	0.97
210_T	214_I	0.847	0.97
18_Y	187_F	0.845	0.97
120_I	127_L	0.843	0.97
3_I	157_F	0.842	0.97
248_Y	256_L	0.839	0.97
130_W	135_D	0.836	0.97
196_Y	199_I	0.834	0.97
86_E	90_D	0.834	0.97
244_S	247_T	0.833	0.97
89_K	99_L	0.833	0.97
130_W	134_I	0.831	0.97
199_I	203_Y	0.831	0.97
5_G	8_F	0.831	0.97
214_I	219_S	0.825	0.97
200_E	203_Y	0.824	0.97
163_L	169_I	0.822	0.97
124_E	128_K	0.817	0.97
24_Y	27_K	0.816	0.97
193_D	197_K	0.810	0.97
37_L	40_Y	0.808	0.96
85_E	89_K	0.808	0.96
72_D	83_F	0.808	0.96
119_L	123_L	0.806	0.96
249_F	256_L	0.805	0.96
163_L	252_I	0.804	0.96
208_K	211_G	0.802	0.96
94_F	98_D	0.801	0.96
48_K	60_E	0.801	0.96
51_G	60_E	0.799	0.96
239_H	253_F	0.799	0.96
164_E	174_I	0.795	0.96
87_Y	96_D	0.793	0.96
230_D	233_I	0.791	0.96
154_F	169_I	0.790	0.96
31_E	34_D	0.776	0.96
127_L	131_I	0.775	0.96
256_L	265_Y	0.774	0.96
195_D	198_E	0.774	0.96
247_T	251_E	0.773	0.95
192_L	196_Y	0.772	0.95
198_E	202_Y	0.771	0.95
47_K	50_E	0.763	0.95
59_N	243_E	0.760	0.95
211_G	217_N	0.759	0.95
224_L	228_N	0.756	0.95
197_K	200_E	0.754	0.95
17_S	187_F	0.754	0.95
167_Y	170_P	0.753	0.95
243_E	246_R	0.751	0.95
217_N	221_F	0.751	0.95
3_I	249_F	0.748	0.95
113_I	118_K	0.745	0.94
11_A	237_F	0.740	0.94
258_C	262_K	0.737	0.94
115_E	118_K	0.737	0.94
236_I	263_W	0.729	0.94
54_W	65_L	0.727	0.94
202_Y	210_T	0.726	0.94
55_S	62_G	0.726	0.94
72_D	76_L	0.724	0.94
157_F	248_Y	0.724	0.94
96_D	100_L	0.724	0.94
202_Y	208_K	0.723	0.94
200_E	207_F	0.721	0.93
238_G	245_D	0.720	0.93
13_G	229_I	0.718	0.93
61_L	189_H	0.716	0.93
190_G	196_Y	0.715	0.93
193_D	196_Y	0.715	0.93
257_N	261_I	0.715	0.93
94_F	99_L	0.714	0.93
143_K	149_L	0.714	0.93
60_E	64_L	0.710	0.93
171_K	180_K	0.703	0.93
62_G	243_E	0.702	0.93
93_D	97_S	0.701	0.92
192_L	195_D	0.692	0.92
177_I	234_I	0.690	0.92
36_E	40_Y	0.685	0.92
101_D	106_E	0.684	0.92
33_Y	39_E	0.681	0.91
67_K	72_D	0.679	0.91
124_E	130_W	0.679	0.91
79_D	83_F	0.678	0.91
97_S	107_E	0.678	0.91
211_G	215_K	0.677	0.91
208_K	217_N	0.677	0.91
223_S	233_I	0.676	0.91
155_L	177_I	0.675	0.91
239_H	242_G	0.675	0.91
219_S	222_K	0.674	0.91
207_F	210_T	0.673	0.91
92_E	96_D	0.667	0.91
10_L	13_G	0.666	0.90
155_L	248_Y	0.665	0.90
241_L	247_T	0.661	0.90
234_I	248_Y	0.660	0.90
237_F	249_F	0.659	0.90
4_I	154_F	0.659	0.90
202_Y	207_F	0.658	0.90
2_Y	55_S	0.656	0.90
2_Y	61_L	0.653	0.90
220_F	226_Y	0.648	0.89
228_N	231_E	0.647	0.89
201_K	205_N	0.640	0.89
131_I	134_I	0.640	0.89
62_G	244_S	0.639	0.89
196_Y	206_L	0.638	0.89
196_Y	203_Y	0.636	0.88
163_L	167_Y	0.635	0.88
34_D	38_F	0.634	0.88
190_G	207_F	0.633	0.88
77_F	81_K	0.631	0.88
91_E	98_D	0.624	0.87
190_G	248_Y	0.623	0.87
119_L	127_L	0.617	0.87
134_I	137_S	0.616	0.87
104_L	111_E	0.611	0.86
145_K	148_D	0.610	0.86
123_L	127_L	0.610	0.86
107_E	123_L	0.608	0.86
108_L	118_K	0.606	0.86
153_L	156_N	0.603	0.86
195_D	200_E	0.602	0.85
192_L	203_Y	0.602	0.85
197_K	204_Q	0.598	0.85
141_K	145_K	0.598	0.85
248_Y	258_C	0.596	0.85
217_N	224_L	0.594	0.85
155_L	220_F	0.592	0.85
120_I	124_E	0.587	0.84
119_L	130_W	0.586	0.84
80_I	87_Y	0.582	0.84
197_K	205_N	0.581	0.83
100_L	103_K	0.580	0.83
41_F	179_G	0.580	0.83
66_K	69_D	0.580	0.83
253_F	256_L	0.578	0.83
62_G	242_G	0.577	0.83
76_L	80_I	0.574	0.83
10_L	187_F	0.573	0.83
108_L	115_E	0.571	0.82
127_L	133_K	0.571	0.82
122_E	126_Y	0.571	0.82
226_Y	233_I	0.567	0.82
206_L	209_N	0.567	0.82
86_E	89_K	0.563	0.82
48_K	51_G	0.563	0.82
89_K	92_E	0.562	0.81
13_G	237_F	0.562	0.81
96_D	104_L	0.561	0.81
10_L	16_T	0.560	0.81
105_I	108_L	0.560	0.81
21_F	57_F	0.559	0.81
240_S	245_D	0.557	0.81
221_F	251_E	0.557	0.81
242_G	246_R	0.555	0.81
244_S	254_E	0.552	0.80
119_L	124_E	0.550	0.80
94_F	100_L	0.547	0.80
259_K	262_K	0.545	0.79
175_I	217_N	0.542	0.79
116_L	123_L	0.540	0.79
178_H	252_I	0.540	0.79
117_D	124_E	0.540	0.79
135_D	149_L	0.539	0.79
62_G	249_F	0.539	0.79
1_L	18_Y	0.538	0.79
209_N	215_K	0.538	0.79
125_E	128_K	0.537	0.78
194_E	199_I	0.535	0.78
20_D	186_I	0.533	0.78
256_L	259_K	0.533	0.78
180_K	184_N	0.533	0.78
85_E	88_L	0.532	0.78
45_I	49_K	0.530	0.77
239_H	246_R	0.529	0.77
14_L	134_I	0.528	0.77
84_L	88_L	0.527	0.77
125_E	129_E	0.525	0.77
80_I	92_E	0.520	0.76
222_K	225_N	0.520	0.76
221_F	233_I	0.519	0.76
246_R	254_E	0.519	0.76
98_D	101_D	0.518	0.76
76_L	79_D	0.517	0.76
10_L	22_I	0.517	0.76
95_S	101_D	0.516	0.76
127_L	134_I	0.515	0.75
153_L	173_N	0.514	0.75
57_F	244_S	0.514	0.75
112_L	119_L	0.511	0.75
243_E	250_K	0.504	0.74
4_I	156_N	0.504	0.74
61_L	187_F	0.503	0.74
229_I	233_I	0.501	0.74
23_E	27_K	0.501	0.74
45_I	177_I	0.501	0.74
22_I	55_S	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2l8kA	1	0.1498	12.1	0.95	Contact Map
1ex9A	1	0.3521	6.1	0.956	Contact Map
2b6hA	2	0.2247	3.5	0.961	Contact Map
1z08A	2	0.2135	3.3	0.961	Contact Map
3x1lB	1	0.2247	3.1	0.962	Contact Map
1z06A	1	0.2022	3.1	0.962	Contact Map
1r2qA	1	0.2135	3.1	0.962	Contact Map
3ds8A	1	0.3408	3	0.962	Contact Map
2gf9A	1	0.2247	3	0.962	Contact Map
3pqcA	1	0.2247	2.9	0.962	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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