GREMLIN Database
DUF4347 - Domain of unknown function (DUF4347)
PFAM: PF14252 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (163)
Sequences: 7465 (6492)
Seq/√Len: 508.5
META: 0.874

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_V40_A2.9111.00
23_E44_R2.5091.00
38_A83_W2.4681.00
126_D136_D2.2791.00
2_V22_V2.2771.00
100_V109_F2.0981.00
32_D66_T2.0881.00
76_Y79_Q2.0401.00
69_D72_T2.0351.00
127_L163_V2.0241.00
101_A141_Y2.0091.00
60_E67_T1.9771.00
11_Y26_V1.9491.00
57_S60_E1.9201.00
11_Y15_L1.9201.00
31_R36_Q1.8731.00
31_R39_E1.8691.00
84_G91_G1.8541.00
6_S26_V1.8541.00
125_T141_Y1.8171.00
3_F40_A1.7931.00
44_R47_L1.7921.00
3_F25_V1.7851.00
6_S11_Y1.7781.00
128_T136_D1.7631.00
128_T140_E1.6741.00
27_L36_Q1.6651.00
52_I95_L1.6501.00
10_D13_T1.6421.00
55_H98_C1.6401.00
28_D31_R1.6161.00
62_Q67_T1.5981.00
138_D141_Y1.5801.00
112_A115_Q1.5761.00
3_F37_I1.5751.00
51_H96_Y1.5731.00
35_E39_E1.5631.00
99_D127_L1.5621.00
110_V123_A1.5601.00
72_T76_Y1.5601.00
97_G100_V1.5521.00
126_D140_E1.5511.00
58_P103_G1.5101.00
92_D120_D1.4721.00
95_L113_L1.4671.00
99_D102_A1.4271.00
61_L68_L1.4251.00
60_E69_D1.4111.00
19_R22_V1.3851.00
12_Q16_A1.3811.00
87_L119_A1.3691.00
130_A133_L1.3521.00
110_V141_Y1.3321.00
93_I117_T1.3181.00
56_G100_V1.2671.00
48_D88_S1.2631.00
61_L95_L1.2571.00
80_L83_W1.2411.00
54_S61_L1.2351.00
2_V18_L1.2281.00
74_A112_A1.2271.00
95_L100_V1.2271.00
28_D36_Q1.2201.00
112_A116_L1.2171.00
151_A157_Q1.2161.00
3_F50_I1.2101.00
111_D115_Q1.1941.00
87_L91_G1.1831.00
107_Q141_Y1.1721.00
53_I152_F1.1661.00
126_D138_D1.1361.00
6_S29_A1.1331.00
125_T140_E1.1331.00
58_P102_A1.1171.00
37_I52_I1.1151.00
70_A112_A1.1111.00
150_L157_Q1.1071.00
114_A143_T1.0981.00
35_E79_Q1.0931.00
18_L24_V1.0811.00
52_I93_I1.0621.00
1_I25_V1.0541.00
8_V53_I1.0521.00
136_D140_E1.0491.00
73_L109_F1.0491.00
51_H94_L1.0481.00
33_G66_T1.0431.00
101_A123_A1.0381.00
2_V53_I1.0301.00
36_Q40_A1.0151.00
32_D35_E1.0111.00
77_A116_L1.0001.00
40_A44_R0.9871.00
103_G106_G0.9421.00
125_T136_D0.9421.00
38_A82_A0.9391.00
104_E108_A0.9331.00
17_G156_A0.9311.00
153_S156_A0.9301.00
152_F157_Q0.9251.00
32_D76_Y0.9101.00
34_L76_Y0.9071.00
79_Q82_A0.9051.00
124_S128_T0.9051.00
34_L68_L0.8991.00
61_L109_F0.8971.00
1_I44_R0.8921.00
15_L24_V0.8881.00
15_L18_L0.8781.00
31_R35_E0.8721.00
105_A108_A0.8691.00
108_A112_A0.8691.00
120_D147_E0.8691.00
124_S140_E0.8651.00
95_L109_F0.8651.00
122_A146_I0.8631.00
37_I83_W0.8631.00
92_D146_I0.8621.00
33_G63_L0.8581.00
54_S97_G0.8561.00
130_A161_Q0.8541.00
1_I40_A0.8511.00
58_P105_A0.8511.00
153_S157_Q0.8461.00
130_A160_Y0.8391.00
111_D143_T0.8381.00
34_L83_W0.8381.00
155_A159_A0.8341.00
14_L53_I0.8301.00
154_A158_A0.8301.00
40_A43_G0.8231.00
10_D162_G0.8211.00
7_S62_Q0.8201.00
47_L50_I0.8121.00
86_A91_G0.8121.00
4_I24_V0.8091.00
23_E47_L0.8081.00
50_I87_L0.8031.00
4_I15_L0.8021.00
111_D141_Y0.8001.00
107_Q111_D0.7831.00
109_F113_L0.7821.00
38_A86_A0.7811.00
78_D81_A0.7801.00
114_A121_V0.7711.00
40_A47_L0.7711.00
33_G64_G0.7681.00
66_T72_T0.7661.00
49_A148_T0.7661.00
70_A108_A0.7651.00
93_I119_A0.7641.00
41_L47_L0.7541.00
152_F155_A0.7511.00
130_A134_G0.7511.00
25_V44_R0.7481.00
47_L86_A0.7371.00
47_L91_G0.7361.00
61_L100_V0.7261.00
33_G36_Q0.7201.00
84_G87_L0.7161.00
68_L72_T0.7011.00
100_V110_V0.6841.00
25_V47_L0.6831.00
74_A77_A0.6821.00
42_A82_A0.6781.00
41_L83_W0.6781.00
73_L116_L0.6731.00
59_G106_G0.6711.00
142_S146_I0.6691.00
15_L26_V0.6671.00
101_A106_G0.6661.00
66_T76_Y0.6631.00
17_G153_S0.6551.00
101_A110_V0.6511.00
2_V19_R0.6501.00
50_I93_I0.6441.00
6_S27_L0.6441.00
104_E107_Q0.6441.00
46_G86_A0.6421.00
108_A111_D0.6371.00
63_L66_T0.6351.00
7_S29_A0.6311.00
1_I41_L0.6301.00
94_L122_A0.6291.00
102_A105_A0.6241.00
80_L117_T0.6211.00
41_L50_I0.6181.00
143_T146_I0.6151.00
6_S28_D0.6141.00
133_L163_V0.6111.00
8_V11_Y0.6071.00
12_Q15_L0.6061.00
13_T16_A0.6040.99
124_S136_D0.6000.99
92_D147_E0.5990.99
92_D144_G0.5980.99
14_L17_G0.5920.99
142_S145_A0.5920.99
4_I11_Y0.5910.99
56_G101_A0.5900.99
110_V143_T0.5880.99
120_D144_G0.5870.99
54_S128_T0.5870.99
33_G37_I0.5850.99
154_A157_Q0.5810.99
152_F156_A0.5810.99
68_L76_Y0.5800.99
132_A161_Q0.5790.99
57_S62_Q0.5780.99
39_E42_A0.5710.99
105_A109_F0.5690.99
22_V51_H0.5620.99
135_G163_V0.5610.99
73_L112_A0.5580.99
38_A80_L0.5550.99
80_L116_L0.5530.99
17_G157_Q0.5530.99
56_G95_L0.5520.99
92_D122_A0.5490.99
47_L88_S0.5490.99
98_C124_S0.5490.99
57_S67_T0.5480.99
157_Q161_Q0.5480.99
107_Q125_T0.5460.99
32_D36_Q0.5430.99
23_E26_V0.5410.99
96_Y151_A0.5380.99
27_L33_G0.5340.99
34_L79_Q0.5310.99
56_G97_G0.5300.99
100_V103_G0.5280.99
22_V49_A0.5250.99
81_A84_G0.5230.99
5_D27_L0.5230.99
62_Q65_N0.5210.99
2_V15_L0.5210.99
130_A135_G0.5150.98
93_I113_L0.5090.98
75_A78_D0.5090.98
76_Y80_L0.5050.98
113_L117_T0.5040.98
83_W109_F0.5040.98
34_L38_A0.5040.98
8_V160_Y0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ho6A 1 0.9634 92.8 0.86 Contact Map
3fzyA 1 0.9207 86.4 0.877 Contact Map
3pa8A 2 0.9451 80.9 0.885 Contact Map
3dh0A 1 0.811 15.3 0.929 Contact Map
2jfzA 2 0.7927 9.1 0.936 Contact Map
4jb8A 2 0.622 8.7 0.936 Contact Map
2gzmA 3 0.8049 8.6 0.936 Contact Map
2h54A 1 0.6098 7.2 0.939 Contact Map
2yv4A 1 0.5854 7.2 0.939 Contact Map
2yx1A 2 0.8415 5.6 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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