GREMLIN Database
DUF4345 - Domain of unknown function (DUF4345)
PFAM: PF14248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 119 (114)
Sequences: 7648 (5884)
Seq/√Len: 551.1
META: 0.901

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_L112_A4.1341.00
40_D98_S2.5941.00
46_R94_D2.5621.00
21_L86_G2.2961.00
62_A72_A2.2711.00
14_L56_G2.2551.00
42_D94_D2.2531.00
23_A26_A2.0691.00
70_R74_L1.9861.00
65_R68_R1.9751.00
65_R69_R1.9321.00
91_L105_L1.8731.00
7_A63_A1.8351.00
77_A115_L1.8261.00
89_L93_L1.8101.00
77_A116_L1.7631.00
46_R93_L1.7271.00
85_L89_L1.7121.00
99_P103_G1.7071.00
100_L104_A1.6641.00
57_L61_L1.6471.00
17_G53_L1.6361.00
10_A60_L1.5881.00
84_G109_L1.5761.00
102_L106_A1.5471.00
5_L115_L1.5421.00
43_S90_S1.5091.00
72_A75_L1.4681.00
91_L96_S1.4601.00
16_I52_L1.4521.00
48_L83_G1.3881.00
11_L15_A1.3771.00
10_A63_A1.3051.00
107_L111_L1.2971.00
77_A112_A1.2961.00
19_L23_A1.2281.00
47_A83_G1.1851.00
90_S94_D1.1791.00
36_L41_L1.1741.00
4_I7_A1.1711.00
20_G49_Y1.1581.00
44_E49_Y1.1531.00
17_G56_G1.1471.00
25_A42_D1.1331.00
98_S101_L1.1281.00
58_L62_A1.1211.00
87_R108_E1.0911.00
61_L72_A1.0861.00
46_R90_S1.0811.00
19_L27_L1.0781.00
88_L92_A1.0781.00
68_R71_T1.0761.00
81_L85_L1.0731.00
61_L68_R1.0701.00
10_A56_G1.0681.00
80_V111_L1.0471.00
15_A19_L1.0431.00
4_I8_L1.0361.00
101_L104_A1.0161.00
97_P102_L1.0101.00
78_L82_G1.0091.00
84_G105_L0.9951.00
103_G107_L0.9931.00
113_P117_L0.9821.00
59_L76_L0.9801.00
61_L65_R0.9611.00
91_L97_P0.9541.00
7_A64_F0.9511.00
20_G44_E0.9461.00
26_A29_A0.9431.00
55_L79_A0.9361.00
88_L109_L0.9281.00
7_A11_L0.9261.00
14_L53_L0.9261.00
9_A111_L0.9191.00
10_A14_L0.9121.00
84_G112_A0.9081.00
69_R72_A0.9071.00
38_S41_L0.9001.00
88_L105_L0.8981.00
103_G106_A0.8931.00
36_L45_L0.8921.00
48_L51_G0.8651.00
54_G82_G0.8641.00
62_A69_R0.8621.00
43_S101_L0.8601.00
28_A45_L0.8531.00
44_E48_L0.8491.00
35_T38_S0.8471.00
56_G60_L0.8431.00
12_I16_I0.8351.00
91_L102_L0.8211.00
66_P69_R0.8171.00
7_A60_L0.8151.00
54_G57_L0.8061.00
60_L64_F0.8051.00
40_D101_L0.8041.00
16_I19_L0.7931.00
5_L9_A0.7911.00
42_D46_R0.7781.00
13_F80_V0.7651.00
21_L53_L0.7591.00
67_E70_R0.7551.00
19_L26_A0.7391.00
24_P42_D0.7271.00
18_L22_L0.7221.00
33_G37_A0.7211.00
3_R7_A0.7211.00
37_A41_L0.7181.00
44_E80_V0.7161.00
96_S99_P0.7161.00
102_L105_L0.7091.00
91_L94_D0.7071.00
20_G27_L0.6911.00
33_G40_D0.6871.00
16_I20_G0.6861.00
105_L109_L0.6851.00
9_A76_L0.6701.00
96_S102_L0.6681.00
71_T74_L0.6671.00
33_G36_L0.6661.00
17_G21_L0.6421.00
69_R73_L0.6371.00
52_L79_A0.6341.00
109_L113_P0.6311.00
3_R66_P0.6271.00
39_P95_G0.6241.00
86_G89_L0.6231.00
15_A18_L0.6231.00
110_V114_L0.6211.00
50_G82_G0.6191.00
44_E87_R0.6171.00
112_A116_L0.6151.00
82_G86_G0.6151.00
28_A34_I0.6081.00
5_L76_L0.6041.00
20_G28_A0.5971.00
50_G54_G0.5931.00
99_P102_L0.5881.00
26_A30_L0.5861.00
111_L115_L0.5821.00
28_A36_L0.5810.99
16_I27_L0.5800.99
106_A110_V0.5790.99
18_L53_L0.5790.99
54_G80_V0.5760.99
110_V113_P0.5730.99
48_L52_L0.5710.99
81_L84_G0.5710.99
14_L60_L0.5680.99
55_L76_L0.5640.99
58_L75_L0.5600.99
47_A86_G0.5590.99
32_L35_T0.5560.99
6_L62_A0.5490.99
74_L116_L0.5480.99
27_L30_L0.5450.99
16_I48_L0.5390.99
51_G83_G0.5380.99
51_G82_G0.5380.99
42_D90_S0.5330.99
36_L42_D0.5260.99
100_L103_G0.5170.99
34_I38_S0.5170.99
79_A83_G0.5160.99
13_F20_G0.5090.99
58_L68_R0.5020.99
86_G90_S0.5020.99
45_L48_L0.5020.99
47_A51_G0.5010.99
24_P27_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.4958 2.6 0.899 Contact Map
4i0uA 4 0.4622 2.4 0.901 Contact Map
4p02A 1 0.8655 1.5 0.912 Contact Map
3wfdB 1 0.5378 1.4 0.914 Contact Map
4humA 1 0.9916 1.3 0.915 Contact Map
4o9uB 2 0.8319 1.1 0.918 Contact Map
3mktA 1 0.9916 1 0.921 Contact Map
4c7rA 3 0.9412 0.9 0.923 Contact Map
4lz6A 1 0.9832 0.9 0.923 Contact Map
4o93B 1 0.605 0.8 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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