GREMLIN Database
DUF4342 - Domain of unknown function (DUF4342)
PFAM: PF14242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 81 (75)
Sequences: 7574 (4631)
Seq/√Len: 534.7
META: 0.943

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_K21_E5.2781.00
34_K78_E3.6811.00
27_N46_T2.7341.00
13_E17_D2.5141.00
39_T42_E2.4531.00
35_N38_K2.3441.00
30_R42_E2.1321.00
29_R45_L2.0611.00
11_S14_E2.0071.00
24_H28_V1.9731.00
32_I42_E1.8431.00
32_I78_E1.8361.00
40_L75_C1.7081.00
14_E17_D1.4571.00
4_R8_F1.4301.00
21_E25_E1.4251.00
26_G46_T1.4121.00
69_A73_T1.3471.00
25_E29_R1.3371.00
72_V75_C1.3031.00
7_E78_E1.2751.00
68_I72_V1.2471.00
34_K39_T1.1771.00
23_I27_N1.1531.00
22_L28_V1.1421.00
32_I80_E1.1381.00
61_V65_V1.1261.00
17_D21_E1.1231.00
35_N40_L1.0841.00
59_A62_L1.0441.00
16_V20_K1.0351.00
31_I43_I1.0071.00
43_I48_G0.9901.00
5_T78_E0.9791.00
56_A60_P0.9571.00
46_T49_V0.9491.00
57_V61_V0.9471.00
6_E10_V0.9441.00
7_E11_S0.9161.00
57_V60_P0.9061.00
46_T50_V0.9001.00
70_A77_I0.8981.00
8_F11_S0.8951.00
3_T80_E0.8941.00
56_A59_A0.8821.00
5_T8_F0.8681.00
4_R11_S0.8481.00
3_T7_E0.8481.00
23_I26_G0.8421.00
9_K74_E0.8321.00
17_D20_K0.8271.00
35_N75_C0.8201.00
5_T9_K0.8041.00
10_V15_L0.7951.00
12_G16_V0.7941.00
63_A66_G0.7891.00
14_E18_K0.7861.00
33_I75_C0.7821.00
31_I48_G0.7751.00
32_I39_T0.7711.00
4_R9_K0.7501.00
5_T32_I0.7461.00
9_K76_T0.7451.00
64_A67_A0.7431.00
16_V65_V0.7351.00
22_L79_V0.7331.00
61_V64_A0.7191.00
13_E20_K0.7011.00
7_E34_K0.6941.00
4_R49_V0.6911.00
26_G49_V0.6761.00
47_V50_V0.6741.00
61_V68_I0.6661.00
8_F79_V0.6651.00
19_V31_I0.6621.00
34_K76_T0.6621.00
43_I61_V0.6621.00
6_E81_R0.6601.00
41_L68_I0.6581.00
63_A68_I0.6531.00
64_A68_I0.6461.00
47_V51_G0.6301.00
44_P47_V0.6251.00
56_A63_A0.6241.00
50_V58_L0.6221.00
20_K24_H0.6191.00
22_L26_G0.6111.00
7_E76_T0.5971.00
74_E78_E0.5941.00
38_K42_E0.5890.99
30_R80_E0.5850.99
34_K37_G0.5850.99
35_N78_E0.5800.99
28_V44_P0.5740.99
40_L72_V0.5730.99
5_T11_S0.5670.99
5_T21_E0.5650.99
9_K14_E0.5560.99
3_T81_R0.5560.99
51_G58_L0.5540.99
8_F18_K0.5460.99
19_V23_I0.5300.99
33_I37_G0.5230.99
67_A71_L0.5200.99
41_L44_P0.5160.99
49_V56_A0.5150.99
58_L77_I0.5140.99
23_I46_T0.5100.99
11_S18_K0.5080.99
63_A67_A0.5060.98
71_L77_I0.5020.98
4_R14_E0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2oarA 7 0.6173 8.8 0.865 Contact Map
3zg9B 1 0 6.2 0.874 Contact Map
3bo0B 1 0.8025 5.1 0.879 Contact Map
2xyqA 1 0.4691 5 0.88 Contact Map
3k9dA 2 0.9877 4.4 0.883 Contact Map
3jz4A 4 0.9753 4.1 0.884 Contact Map
2ww9B 1 0.7284 4 0.885 Contact Map
3ek1A 5 0.9753 3.6 0.888 Contact Map
2w8nA 4 0.963 3.5 0.888 Contact Map
3my7A 2 0.9877 3.3 0.889 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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