GREMLIN Database
YHYH - YHYH protein
PFAM: PF14240 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 196 (192)
Sequences: 3396 (2412)
Seq/√Len: 174.1
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
169_G182_F3.6531.00
123_R160_D3.6231.00
130_R155_V3.5841.00
10_L104_F3.1131.00
130_R158_S2.9651.00
99_W174_Y2.8011.00
113_S123_R2.7941.00
166_G179_Y2.7341.00
67_H77_H2.7101.00
111_G125_M2.6621.00
162_D166_G2.6371.00
50_Y148_F2.5901.00
67_H75_H2.5741.00
134_G137_G2.5321.00
162_D179_Y2.5071.00
169_G180_A2.4921.00
64_N82_A2.4881.00
128_S154_Y2.4801.00
164_C193_C2.4301.00
113_S121_G2.4181.00
130_R153_E2.3121.00
128_S158_S2.2771.00
43_D47_G2.1901.00
26_A32_F2.1321.00
97_I183_V2.0991.00
124_R185_D2.0911.00
132_K153_E1.9681.00
115_A120_S1.9531.00
96_L99_W1.6871.00
49_N150_E1.6841.00
125_M182_F1.6671.00
31_P73_A1.6451.00
22_A31_P1.6371.00
125_M160_D1.6361.00
24_G32_F1.6131.00
44_R47_G1.5821.00
36_D49_N1.5741.00
54_G147_T1.5341.00
128_S159_G1.5271.00
33_D69_Q1.5261.00
167_R180_A1.5081.00
167_R182_F1.4921.00
98_G106_I1.4821.00
128_S156_A1.4651.00
104_F166_G1.4541.00
174_Y177_G1.4511.00
26_A76_Y1.4211.00
126_K160_D1.4141.00
25_V31_P1.3981.00
39_S42_N1.3831.00
56_A147_T1.3761.00
51_E152_Y1.3541.00
100_A106_I1.3351.00
66_A76_Y1.3271.00
43_D46_S1.3251.00
48_W52_A1.2961.00
146_G151_D1.2891.00
155_V158_S1.2751.00
140_G144_P1.2361.00
69_Q72_G1.2311.00
27_L96_L1.2241.00
2_F31_P1.2101.00
53_L78_G1.1971.00
36_D39_S1.1891.00
116_T120_S1.1841.00
66_A74_Y1.1761.00
88_D92_H1.1751.00
89_S92_H1.1741.00
191_P194_F1.1731.00
32_F69_Q1.1541.00
139_G144_P1.1381.00
183_V190_I1.1251.00
183_V191_P1.1231.00
115_A118_A1.1081.00
24_G29_G1.1001.00
175_P178_T1.0981.00
117_D120_S1.0981.00
140_G145_D1.0871.00
11_A15_T1.0861.00
92_H95_P1.0771.00
87_L90_T1.0531.00
9_T104_F1.0521.00
94_S122_I1.0481.00
111_G180_A1.0460.99
114_N120_S1.0410.99
128_S155_V1.0370.99
60_G68_V1.0360.99
169_G172_P1.0260.99
114_N117_D1.0230.99
139_G142_Y1.0220.99
131_L145_D1.0160.99
39_S49_N1.0080.99
69_Q73_A1.0060.99
109_P124_R1.0050.99
51_E149_T1.0030.99
11_A14_T0.9780.99
95_P108_G0.9730.99
15_T19_G0.9680.99
94_S180_A0.9630.99
35_G149_T0.9610.99
118_A121_G0.9560.99
19_G36_D0.9280.99
148_F151_D0.9240.99
140_G143_Y0.9080.99
88_D91_Q0.9050.99
62_D74_Y0.8940.98
110_Y122_I0.8870.98
2_F22_A0.8860.98
15_T164_C0.8770.98
52_A61_L0.8720.98
153_E158_S0.8690.98
36_D52_A0.8680.98
54_G57_E0.8630.98
79_N183_V0.8450.98
21_G194_F0.8440.98
10_L15_T0.8400.98
125_M167_R0.8380.98
112_Y121_G0.8350.98
185_D188_P0.8350.98
139_G143_Y0.8330.97
2_F25_V0.8320.97
173_E177_G0.8300.97
109_P185_D0.8300.97
62_D66_A0.8270.97
32_F73_A0.8250.97
171_T175_P0.8230.97
110_Y124_R0.8200.97
174_Y178_T0.8160.97
161_L165_N0.8160.97
79_N84_L0.8140.97
134_G139_G0.8120.97
49_N149_T0.8100.97
49_N52_A0.8030.97
182_F191_P0.8000.97
16_T19_G0.8000.97
171_T174_Y0.7980.97
22_A101_A0.7960.97
38_E68_V0.7890.97
22_A73_A0.7890.97
80_P83_L0.7880.97
92_H122_I0.7800.96
54_G144_P0.7770.96
50_Y54_G0.7760.96
38_E59_L0.7750.96
171_T177_G0.7740.96
162_D184_T0.7720.96
33_D38_E0.7710.96
114_N133_S0.7710.96
114_N170_V0.7690.96
65_N81_T0.7670.96
40_W137_G0.7610.96
142_Y145_D0.7570.96
54_G152_Y0.7560.96
104_F179_Y0.7530.95
146_G152_Y0.7530.95
132_K145_D0.7520.95
94_S169_G0.7460.95
154_Y163_E0.7430.95
108_G182_F0.7420.95
50_Y53_L0.7410.95
156_A163_E0.7360.95
22_A33_D0.7360.95
152_Y187_F0.7340.95
146_G150_E0.7330.95
161_L166_G0.7250.94
107_Y173_E0.7240.94
62_D75_H0.7190.94
17_L35_G0.7170.94
62_D67_H0.7140.94
48_W138_P0.7080.94
41_N47_G0.7050.94
87_L91_Q0.7040.94
10_L14_T0.7040.94
132_K142_Y0.7030.94
30_V76_Y0.7020.93
55_G61_L0.6940.93
78_G81_T0.6900.93
49_N53_L0.6890.93
38_E70_P0.6830.93
128_S160_D0.6810.92
23_I194_F0.6810.92
168_F178_T0.6810.92
87_L92_H0.6770.92
104_F178_T0.6730.92
154_Y159_G0.6730.92
166_G184_T0.6690.92
114_N121_G0.6690.92
146_G153_E0.6660.92
9_T13_G0.6640.91
123_R126_K0.6620.91
127_S186_D0.6610.91
133_S142_Y0.6580.91
135_T139_G0.6570.91
141_A144_P0.6530.91
41_N46_S0.6520.91
35_G51_E0.6500.91
114_N118_A0.6490.90
97_I109_P0.6430.90
25_V101_A0.6380.90
86_S89_S0.6360.90
7_N12_T0.6350.90
112_Y120_S0.6350.90
18_T21_G0.6300.89
14_T164_C0.6300.89
48_W53_L0.6260.89
27_L99_W0.6180.88
80_P84_L0.6160.88
84_L108_G0.6130.88
113_S120_S0.6110.88
28_N74_Y0.6110.88
3_R6_L0.6080.87
65_N78_G0.6070.87
53_L61_L0.6040.87
23_I190_I0.6020.87
35_G49_N0.6010.87
22_A25_V0.5970.86
53_L56_A0.5950.86
40_W48_W0.5950.86
37_A72_G0.5930.86
53_L65_N0.5890.86
179_Y184_T0.5880.86
118_A170_V0.5850.85
187_F192_R0.5850.85
7_N121_G0.5840.85
14_T17_L0.5830.85
94_S182_F0.5830.85
154_Y158_S0.5820.85
34_P149_T0.5800.85
128_S157_G0.5800.85
100_A184_T0.5790.85
160_D167_R0.5780.85
48_W51_E0.5770.85
37_A75_H0.5750.84
51_E192_R0.5680.84
13_G18_T0.5650.83
168_F180_A0.5650.83
7_N10_L0.5580.83
127_S152_Y0.5580.83
111_G120_S0.5550.82
64_N76_Y0.5550.82
189_Y193_C0.5550.82
172_P175_P0.5540.82
146_G154_Y0.5540.82
79_N109_P0.5530.82
84_L89_S0.5480.81
15_T18_T0.5470.81
144_P152_Y0.5440.81
4_I25_V0.5440.81
157_G160_D0.5420.81
181_Y184_T0.5410.81
113_S126_K0.5400.81
162_D165_N0.5380.80
82_A85_E0.5330.80
139_G145_D0.5310.79
78_G83_L0.5290.79
131_L140_G0.5260.79
64_N81_T0.5250.79
107_Y177_G0.5250.79
37_A52_A0.5240.79
143_Y148_F0.5240.79
95_P109_P0.5230.78
149_T152_Y0.5210.78
18_T35_G0.5200.78
32_F190_I0.5190.78
88_D95_P0.5190.78
94_S172_P0.5190.78
111_G121_G0.5180.78
116_T119_T0.5180.78
23_I26_A0.5170.78
115_A121_G0.5170.78
86_S90_T0.5160.77
37_A67_H0.5160.77
170_V176_N0.5150.77
167_R175_P0.5150.77
55_G58_N0.5140.77
29_G66_A0.5140.77
5_P8_P0.5130.77
167_R170_V0.5120.77
84_L88_D0.5110.77
12_T116_T0.5110.77
105_P175_P0.5090.77
112_Y171_T0.5080.76
8_P100_A0.5070.76
89_S95_P0.5060.76
9_T12_T0.5040.76
117_D121_G0.5010.75
48_W54_G0.5000.75
66_A169_G0.5000.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2w91A 1 0.2398 3.8 0.966 Contact Map
4jmqA 1 0.352 2.2 0.97 Contact Map
4aeqA 2 0.1633 1.8 0.971 Contact Map
2m83A 1 0.2398 1.8 0.971 Contact Map
1m5hA 5 0.3673 1.5 0.973 Contact Map
1m5sA 4 0.3673 1.4 0.973 Contact Map
2r5oA 3 0.3061 1.4 0.973 Contact Map
2dk1A 1 0.1071 1.2 0.974 Contact Map
4tmaI 1 0.0816 1.1 0.974 Contact Map
1ftrA 4 0.3673 1.1 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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