GREMLIN Database
DUF4340 - Domain of unknown function (DUF4340)
PFAM: PF14238 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 185 (167)
Sequences: 25409 (20662)
Seq/√Len: 1598.9
META: 0.965

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
62_L77_R3.0661.00
38_D41_R2.7641.00
117_R129_T2.7511.00
52_T60_T2.4781.00
60_T79_A2.4231.00
119_E129_T2.3441.00
76_A87_V2.3251.00
50_T60_T2.2841.00
39_L77_R2.2111.00
141_L144_P2.1091.00
78_L81_E2.0851.00
111_D114_D2.0831.00
98_S101_D2.0711.00
134_G137_W2.0521.00
117_R131_E1.9241.00
13_Q17_E1.9151.00
166_A169_F1.8761.00
50_T62_L1.8731.00
62_L79_A1.8401.00
2_R8_D1.8281.00
40_A45_D1.7951.00
89_G93_D1.7861.00
11_A16_V1.7521.00
122_T127_T1.7111.00
106_R165_R1.7041.00
29_E88_S1.6871.00
19_L102_W1.6831.00
39_L84_V1.6711.00
16_V20_L1.6531.00
103_R169_F1.6181.00
133_D138_W1.5791.00
123_A126_G1.5781.00
119_E127_T1.5771.00
3_I11_A1.5581.00
121_I126_G1.4991.00
151_S155_E1.4831.00
63_I74_V1.4731.00
39_L44_L1.4421.00
44_L62_L1.4371.00
97_K101_D1.4251.00
73_G86_L1.4201.00
149_A154_V1.4131.00
100_D168_D1.4131.00
155_E159_S1.3901.00
31_F34_E1.3631.00
150_D153_K1.3621.00
12_D15_A1.3371.00
112_P162_S1.3211.00
18_S22_A1.3161.00
54_T57_D1.3031.00
17_E21_S1.3011.00
39_L82_P1.2911.00
21_S25_D1.2351.00
52_T58_L1.2331.00
153_K156_S1.2261.00
28_A85_Y1.2251.00
34_E83_R1.2211.00
10_P104_D1.2041.00
106_R109_D1.1991.00
42_Y84_V1.1931.00
12_D105_K1.1721.00
112_P159_S1.1641.00
154_V158_L1.1641.00
76_A85_Y1.1601.00
29_E73_G1.1441.00
43_G65_K1.1401.00
4_T8_D1.1371.00
30_R86_L1.1331.00
36_P39_L1.1231.00
54_T58_L1.1171.00
22_A94_S1.1141.00
67_T70_D1.1101.00
92_L96_D1.1091.00
74_V92_L1.1081.00
130_L154_V1.1051.00
3_I6_P1.1041.00
121_I127_T1.1011.00
47_P50_T1.0981.00
67_T86_L1.0911.00
131_E142_T1.0881.00
63_I76_A1.0711.00
156_S159_S1.0711.00
143_K146_G1.0671.00
100_D105_K1.0661.00
12_D104_D1.0641.00
152_A156_S1.0581.00
97_K102_W1.0511.00
3_I99_P1.0321.00
133_D136_G1.0271.00
127_T143_K1.0181.00
121_I124_G1.0141.00
59_A78_L1.0141.00
18_S94_S1.0131.00
133_D137_W1.0061.00
61_L76_A1.0051.00
18_S21_S1.0021.00
121_I125_G0.9971.00
112_P155_E0.9961.00
31_F83_R0.9931.00
93_D96_D0.9871.00
19_L95_L0.9831.00
66_K74_V0.9751.00
42_Y75_Y0.9741.00
14_S18_S0.9601.00
77_R82_P0.9531.00
126_G130_L0.9491.00
15_A97_K0.9471.00
15_A18_S0.9451.00
55_D58_L0.9401.00
142_T146_G0.9241.00
141_L145_A0.9171.00
110_F162_S0.9151.00
67_T73_G0.9121.00
144_P147_A0.9111.00
74_V78_L0.9111.00
105_K166_A0.9101.00
23_L53_L0.8971.00
48_A74_V0.8961.00
141_L146_G0.8931.00
12_D165_R0.8921.00
110_F115_V0.8861.00
66_K89_G0.8861.00
66_K71_G0.8821.00
143_K147_A0.8791.00
141_L147_A0.8711.00
73_G88_S0.8591.00
137_W140_L0.8511.00
28_A31_F0.8501.00
135_D138_W0.8501.00
22_A90_S0.8441.00
134_G138_W0.8431.00
88_S91_L0.8351.00
70_D73_G0.8331.00
159_S163_D0.8301.00
5_E8_D0.8231.00
156_S160_A0.8211.00
2_R10_P0.8181.00
28_A78_L0.8031.00
122_T126_G0.8001.00
75_Y86_L0.7941.00
39_L42_Y0.7931.00
132_R135_D0.7921.00
65_K75_Y0.7911.00
59_A79_A0.7901.00
37_A41_R0.7831.00
15_A105_K0.7811.00
129_T143_K0.7811.00
122_T125_G0.7801.00
129_T142_T0.7791.00
103_R166_A0.7791.00
77_R80_G0.7721.00
20_L24_A0.7681.00
66_K92_L0.7661.00
67_T71_G0.7621.00
6_P168_D0.7621.00
141_L149_A0.7611.00
33_T36_P0.7521.00
103_R107_L0.7511.00
152_A155_E0.7491.00
26_L91_L0.7491.00
55_D59_A0.7431.00
7_V99_P0.7251.00
121_I128_L0.7221.00
72_G89_G0.7221.00
140_L143_K0.7181.00
107_L166_A0.7121.00
44_L77_R0.7051.00
132_R137_W0.7041.00
14_S17_E0.6941.00
98_S102_W0.6891.00
36_P82_P0.6891.00
49_A92_L0.6881.00
35_D82_P0.6811.00
15_A101_D0.6801.00
104_D109_D0.6771.00
30_R33_T0.6761.00
118_I157_L0.6631.00
74_V87_V0.6521.00
90_S93_D0.6511.00
22_A25_D0.6501.00
142_T145_A0.6481.00
68_P72_G0.6471.00
21_S24_A0.6451.00
3_I9_Y0.6451.00
31_F85_Y0.6431.00
140_L146_G0.6421.00
94_S97_K0.6351.00
2_R6_P0.6331.00
100_D103_R0.6321.00
111_D162_S0.6291.00
145_A149_A0.6281.00
158_L162_S0.6281.00
3_I7_V0.6271.00
132_R136_G0.6221.00
112_P116_T0.6181.00
28_A87_V0.6171.00
49_A96_D0.6151.00
67_T72_G0.6141.00
36_P41_R0.6131.00
99_P103_R0.6121.00
118_I130_L0.6101.00
32_V75_Y0.6031.00
6_P9_Y0.6021.00
33_T39_L0.5991.00
107_L164_L0.5881.00
35_D38_D0.5861.00
33_T37_A0.5841.00
74_V89_G0.5811.00
132_R138_W0.5801.00
29_E32_V0.5781.00
48_A62_L0.5751.00
81_E85_Y0.5661.00
123_A128_L0.5641.00
159_S162_S0.5611.00
38_D42_Y0.5591.00
39_L45_D0.5571.00
77_R81_E0.5551.00
65_K68_P0.5551.00
6_P103_R0.5551.00
87_V91_L0.5541.00
123_A127_T0.5531.00
115_V158_L0.5531.00
116_T131_E0.5511.00
124_G127_T0.5461.00
50_T79_A0.5421.00
26_L87_V0.5391.00
53_L59_A0.5371.00
44_L47_P0.5361.00
30_R73_G0.5351.00
68_P71_G0.5331.00
118_I158_L0.5331.00
40_A46_K0.5301.00
129_T132_R0.5291.00
136_G151_S0.5281.00
27_K88_S0.5231.00
44_L84_V0.5221.00
112_P158_L0.5211.00
37_A42_Y0.5211.00
89_G92_L0.5151.00
38_D43_G0.5151.00
44_L64_G0.5141.00
101_D105_K0.5131.00
43_G47_P0.5101.00
48_A65_K0.5091.00
66_K72_G0.5081.00
62_L80_G0.5061.00
105_K165_R0.5061.00
140_L144_P0.5041.00
77_R84_V0.5031.00
155_E158_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2l5yA 1 0.3351 2.7 0.936 Contact Map
2k60A 1 0.3351 2.1 0.94 Contact Map
3m4aA 1 0.8649 2.1 0.94 Contact Map
2fd4A 1 0.5189 2 0.94 Contact Map
1dd4C 7 0.2162 1.9 0.941 Contact Map
1zavU 5 0.1622 1.7 0.943 Contact Map
2jmcA 1 0.3784 1.7 0.943 Contact Map
1wjxA 1 0.6 1.5 0.944 Contact Map
3nfgB 2 0.4595 1.3 0.946 Contact Map
4bjjB 1 0.1838 1.3 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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