GREMLIN Database
DUF4337 - Domain of unknown function (DUF4337)
PFAM: PF14235 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 161 (156)
Sequences: 10672 (6489)
Seq/√Len: 519.5
META: 0.968

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K101_K4.9641.00
99_K102_E3.2681.00
80_A84_A2.9561.00
85_E88_R2.5751.00
78_K81_K2.3791.00
47_S93_K2.1961.00
61_E83_R2.1741.00
95_E98_A2.0921.00
91_S94_K2.0661.00
88_R92_E1.9901.00
40_W97_K1.9891.00
50_Q93_K1.9681.00
39_Q42_F1.9611.00
39_Q99_K1.9481.00
83_R87_A1.8731.00
84_A87_A1.8481.00
102_E105_A1.8471.00
57_A83_R1.7671.00
105_A109_E1.7631.00
95_E99_K1.7411.00
81_K85_E1.7281.00
90_E94_K1.7131.00
109_E113_R1.6981.00
76_E80_A1.6791.00
46_K92_E1.6761.00
94_K97_K1.6711.00
57_A86_A1.6561.00
87_A91_S1.6551.00
50_Q54_E1.6301.00
7_T143_W1.6201.00
91_S95_E1.6181.00
105_A108_D1.6171.00
77_K80_A1.6141.00
80_A83_R1.5841.00
90_E93_K1.5631.00
59_L63_L1.5531.00
155_V159_L1.5121.00
52_L55_L1.5081.00
73_A77_K1.5051.00
101_K105_A1.4911.00
101_K104_E1.4901.00
39_Q96_I1.4821.00
11_L150_G1.4761.00
94_K98_A1.4291.00
50_Q90_E1.4261.00
103_L106_E1.4251.00
34_I37_S1.4211.00
143_W147_L1.3951.00
81_K84_A1.3861.00
147_L151_A1.3811.00
32_A106_E1.3641.00
151_A155_V1.3321.00
144_Y148_G1.3181.00
148_G152_V1.3161.00
35_E103_L1.3141.00
131_A146_S1.3101.00
98_A102_E1.2851.00
36_A104_E1.2821.00
39_Q103_L1.2691.00
79_I83_R1.2631.00
102_E106_E1.2501.00
64_L76_E1.2361.00
110_A113_R1.2281.00
19_S23_G1.1741.00
106_E109_E1.1501.00
38_D42_F1.1401.00
77_K81_K1.1341.00
89_Y92_E1.1261.00
42_F96_I1.1231.00
57_A61_E1.1061.00
18_A157_G1.0991.00
56_A59_L1.0841.00
72_K76_E1.0811.00
87_A90_E1.0791.00
28_E32_A1.0761.00
23_G26_Q1.0741.00
98_A101_K1.0711.00
112_A115_D1.0511.00
58_D78_K1.0451.00
58_D82_Y1.0381.00
99_K103_L1.0381.00
69_P72_K1.0361.00
48_I52_L1.0281.00
74_A77_K1.0221.00
42_F46_K1.0191.00
32_A35_E1.0141.00
109_E112_A1.0021.00
108_D112_A0.9961.00
24_N118_D0.9741.00
129_V132_S0.9711.00
111_L115_D0.9541.00
141_W144_Y0.9531.00
134_A143_W0.9431.00
124_L153_G0.9381.00
54_E86_A0.9221.00
70_A73_A0.9201.00
32_A103_L0.9161.00
73_A76_E0.9111.00
35_E38_D0.9071.00
145_L149_L0.9051.00
120_A157_G0.8951.00
112_A116_R0.8901.00
114_A118_D0.8841.00
14_L154_L0.8801.00
32_A110_A0.8691.00
35_E108_D0.8671.00
76_E79_I0.8671.00
58_D61_E0.8591.00
42_F47_S0.8591.00
35_E39_Q0.8501.00
61_E78_K0.8491.00
71_A74_A0.8491.00
140_R144_Y0.8301.00
30_L34_I0.8281.00
92_E95_E0.8251.00
54_E90_E0.8091.00
158_A161_F0.8041.00
29_A111_L0.8021.00
14_L124_L0.7961.00
116_R159_L0.7931.00
68_A71_A0.7911.00
111_L114_A0.7771.00
18_A120_A0.7711.00
85_E89_Y0.7691.00
21_L24_N0.7661.00
25_A110_A0.7601.00
95_E102_E0.7531.00
7_T147_L0.7501.00
56_A82_Y0.7471.00
37_S41_A0.7411.00
58_D81_K0.7391.00
7_T11_L0.7341.00
131_A134_A0.7321.00
21_L25_A0.7271.00
75_A78_K0.7251.00
46_K96_I0.7221.00
69_P73_A0.7201.00
20_L122_A0.7171.00
50_Q86_A0.7131.00
22_G26_Q0.7091.00
54_E85_E0.7091.00
52_L56_A0.7031.00
74_A78_K0.7011.00
72_K75_A0.6941.00
140_R143_W0.6901.00
47_S50_Q0.6891.00
134_A142_L0.6871.00
78_K82_Y0.6861.00
92_E96_I0.6851.00
62_L75_A0.6851.00
143_W146_S0.6831.00
53_A82_Y0.6811.00
75_A79_I0.6801.00
27_T31_L0.6791.00
8_T125_Q0.6771.00
26_Q118_D0.6741.00
125_Q128_I0.6721.00
152_V156_L0.6691.00
55_L82_Y0.6671.00
24_N27_T0.6661.00
26_Q30_L0.6631.00
20_L23_G0.6621.00
63_L75_A0.6601.00
91_S98_A0.6521.00
51_H54_E0.6511.00
85_E90_E0.6461.00
123_L152_V0.6451.00
57_A79_I0.6441.00
27_T30_L0.6441.00
19_S22_G0.6421.00
5_A13_V0.6421.00
144_Y147_L0.6351.00
64_L72_K0.6291.00
28_E31_L0.6261.00
51_H85_E0.6261.00
98_A105_A0.6231.00
20_L27_T0.6231.00
59_L62_L0.6221.00
26_Q114_A0.6161.00
83_R86_A0.6141.00
54_E58_D0.5890.99
22_G25_A0.5860.99
41_A47_S0.5850.99
123_L149_L0.5850.99
53_A85_E0.5780.99
61_E79_I0.5740.99
19_S26_Q0.5720.99
53_A56_A0.5710.99
51_H89_Y0.5640.99
62_L78_K0.5640.99
23_G27_T0.5640.99
113_R116_R0.5580.99
19_S121_E0.5580.99
125_Q129_V0.5550.99
86_A89_Y0.5550.99
156_L159_L0.5540.99
88_R91_S0.5530.99
70_A74_A0.5510.99
117_F160_G0.5470.99
55_L59_L0.5470.99
106_E110_A0.5410.99
33_Q107_R0.5390.99
47_S92_E0.5390.99
23_G121_E0.5370.99
3_R140_R0.5350.99
43_Y47_S0.5350.99
60_L79_I0.5340.99
104_E107_R0.5340.99
23_G118_D0.5330.99
6_L10_I0.5310.99
16_A21_L0.5310.99
48_I51_H0.5270.99
157_G161_F0.5270.99
40_W104_E0.5260.99
28_E110_A0.5260.99
89_Y96_I0.5220.99
71_A75_A0.5200.99
4_V7_T0.5200.99
47_S51_H0.5190.99
18_A124_L0.5180.99
41_A44_Q0.5170.99
22_G118_D0.5150.98
41_A45_A0.5140.98
9_A12_A0.5130.98
116_R119_L0.5110.98
5_A8_T0.5110.98
18_A121_E0.5110.98
20_L26_Q0.5080.98
6_L13_V0.5070.98
59_L64_L0.5060.98
127_A149_L0.5050.98
42_F97_K0.5030.98
107_R114_A0.5020.98
25_A117_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yy0A 6 0.3168 20.5 0.924 Contact Map
2f95B 2 0.118 11.8 0.932 Contact Map
4wl1A 3 0 11.7 0.932 Contact Map
4aurA 1 0.5963 9.8 0.934 Contact Map
1gmjA 2 0.4037 5.5 0.941 Contact Map
1jcdA 3 0.323 5.3 0.942 Contact Map
3ojaB 1 0.5466 4.9 0.943 Contact Map
3aeiA 3 0.4969 4.7 0.943 Contact Map
3layA 5 0.4845 4.6 0.944 Contact Map
4cgkA 3 0.5963 4.4 0.944 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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