GREMLIN Database
DUF4333 - Domain of unknown function (DUF4333)
PFAM: PF14230 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (72)
Sequences: 5428 (4101)
Seq/√Len: 483.3
META: 0.875

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_T68_T2.8401.00
57_T70_T2.4431.00
60_V69_V2.2921.00
27_A42_V1.8131.00
51_K54_A1.7741.00
59_T68_T1.6611.00
42_V60_V1.6181.00
6_C11_G1.5721.00
25_G29_Q1.5691.00
26_I71_V1.5571.00
49_K54_A1.5521.00
26_I29_Q1.5451.00
6_C12_G1.5321.00
52_V76_V1.5231.00
28_D32_D1.4821.00
19_A23_E1.4821.00
59_T66_T1.4211.00
48_V54_A1.4141.00
14_T49_K1.3841.00
25_G28_D1.3571.00
29_Q32_D1.3211.00
54_A73_V1.3141.00
48_V73_V1.3091.00
22_V71_V1.2881.00
61_T66_T1.2541.00
19_A47_D1.2361.00
41_S61_T1.2111.00
29_Q33_Q1.2041.00
55_T70_T1.2001.00
16_T47_D1.1811.00
17_L22_V1.1801.00
50_V73_V1.1801.00
73_V76_V1.1671.00
22_V25_G1.1501.00
27_A39_V1.1351.00
22_V56_F1.1311.00
18_D21_K1.1291.00
62_V67_Y1.1211.00
45_P56_F1.1111.00
31_A38_K1.1101.00
60_V67_Y1.0841.00
15_T50_V1.0741.00
7_S11_G1.0671.00
48_V56_F1.0491.00
30_L69_V1.0311.00
20_A23_E1.0221.00
21_K25_G1.0211.00
18_D56_F1.0181.00
56_F73_V0.9921.00
24_K28_D0.9861.00
4_A11_G0.9581.00
55_T72_T0.9441.00
40_T62_V0.9361.00
8_A11_G0.9231.00
62_V65_E0.9141.00
46_D56_F0.9091.00
27_A31_A0.8821.00
4_A8_A0.8761.00
67_Y71_V0.8651.00
5_G8_A0.8491.00
8_A12_G0.8471.00
52_V73_V0.8461.00
19_A46_D0.8451.00
45_P48_V0.8401.00
27_A40_T0.8211.00
6_C13_G0.7861.00
21_K24_K0.7861.00
4_A7_S0.7591.00
53_G72_T0.7441.00
31_A39_V0.7381.00
42_V45_P0.7321.00
26_I42_V0.7171.00
24_K27_A0.7111.00
7_S12_G0.6961.00
23_E27_A0.6961.00
52_V75_D0.6941.00
22_V26_I0.6751.00
34_Y62_V0.6701.00
17_L73_V0.6551.00
30_L34_Y0.6371.00
45_P57_T0.6301.00
5_G12_G0.6291.00
29_Q62_V0.6261.00
16_T49_K0.6241.00
18_D47_D0.6241.00
75_D78_G0.6090.99
62_V66_T0.6060.99
60_V65_E0.6010.99
44_C58_C0.5870.99
46_D49_K0.5820.99
23_E43_T0.5820.99
16_T50_V0.5810.99
30_L40_T0.5720.99
20_A24_K0.5700.99
7_S13_G0.5690.99
36_V62_V0.5670.99
31_A34_Y0.5640.99
17_L50_V0.5640.99
22_V48_V0.5630.99
4_A12_G0.5540.99
45_P73_V0.5530.99
34_Y39_V0.5270.98
40_T61_T0.5240.98
15_T49_K0.5180.98
11_G14_T0.5130.98
30_L60_V0.5040.98
8_A13_G0.5010.98
46_D51_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bhrA 1 0.8846 14.4 0.823 Contact Map
3pmqA 1 0.3205 10.5 0.834 Contact Map
1s9cA 2 0.9744 5.4 0.854 Contact Map
3khpA 3 0.9615 4.3 0.862 Contact Map
4lm8A 1 0.3846 3.8 0.864 Contact Map
3l0zA 2 0.3846 3.5 0.867 Contact Map
3kh8A 2 0.9744 3.2 0.87 Contact Map
3u4gA 2 0.4487 3 0.871 Contact Map
4q53A 2 0.8846 2.9 0.872 Contact Map
3fdrA 1 0.641 2.9 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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