GREMLIN Database
DUF4330 - Domain of unknown function (DUF4330)
PFAM: PF14221 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 167 (160)
Sequences: 1799 (1532)
Seq/√Len: 121.1
META: 0.839

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_D109_T4.2911.00
90_T127_E4.0701.00
54_E127_E3.3531.00
92_T127_E3.2041.00
76_K90_T3.1111.00
66_E70_D2.8971.00
99_A121_D2.8491.00
60_R121_D2.7061.00
32_V36_P2.5581.00
15_N19_L2.4261.00
33_F37_G2.3331.00
128_G139_V2.2641.00
56_T127_E2.2251.00
5_D9_R2.1961.00
100_T114_P2.1681.00
93_D125_T2.1091.00
98_P114_P2.0281.00
153_K158_E1.9711.00
73_V93_D1.9641.00
136_G145_K1.9211.00
65_P68_L1.9071.00
100_T112_A1.8561.00
146_V166_V1.8181.00
30_A34_Y1.8141.00
154_T157_Y1.8021.00
94_V124_I1.7821.00
54_E129_K1.7481.00
20_L27_A1.6851.00
52_P129_K1.6841.00
71_I91_I1.6621.00
105_D111_V1.6601.00
55_V130_A1.6511.00
97_E123_L1.6291.00
96_V120_Y1.6181.00
132_I137_I1.6061.00
86_Y89_V1.5991.00
8_G12_G1.5841.00
72_K75_D1.5611.00
71_I75_D1.4751.00
8_G14_I1.4391.00
13_K19_L1.4181.00
146_V165_D1.4031.00
3_I6_E1.3881.00
31_G35_K1.3801.00
29_A33_F1.3531.00
35_K38_G1.3351.00
76_K88_E1.3271.00
61_G159_F1.3021.00
4_I8_G1.2961.00
58_T123_L1.2751.00
73_V94_V1.2751.00
8_G11_F1.2190.99
163_V166_V1.2160.99
95_E123_L1.2090.99
56_T125_T1.2040.99
92_T125_T1.1810.99
151_E158_E1.1690.99
23_L27_A1.1610.99
115_D118_G1.1480.99
95_E125_T1.1390.99
31_G34_Y1.1350.99
149_P160_N1.1340.99
54_E58_T1.1310.99
143_E148_T1.1270.99
115_D120_Y1.1250.99
69_A120_Y1.1230.99
97_E121_D1.1210.99
28_V31_G1.1190.99
62_L121_D1.1040.99
14_I22_I1.0990.99
59_V161_G1.0800.98
77_V126_L1.0750.98
142_Q150_I1.0520.98
75_D156_N1.0420.98
32_V35_K1.0290.98
147_G152_L1.0150.98
15_N18_D1.0120.98
34_Y37_G0.9700.97
123_L164_I0.9600.97
71_I157_Y0.9540.97
10_L14_I0.9440.96
75_D157_Y0.9400.96
145_K153_K0.9280.96
9_R12_G0.9210.96
149_P162_T0.9160.96
135_D143_E0.9090.96
61_G64_V0.8940.95
130_A136_G0.8900.95
144_I148_T0.8900.95
53_V56_T0.8810.95
9_R13_K0.8770.95
66_E120_Y0.8770.95
24_V28_V0.8750.94
63_G119_R0.8740.94
15_N139_V0.8740.94
11_F14_I0.8730.94
66_E118_G0.8630.94
99_A119_R0.8580.94
14_I19_L0.8520.94
101_V115_D0.8470.93
16_I37_G0.8440.93
4_I7_K0.8420.93
128_G142_Q0.8380.93
79_D150_I0.8340.93
61_G65_P0.8270.93
34_Y38_G0.8260.93
99_A115_D0.8240.93
102_A110_V0.8230.92
105_D108_G0.8210.92
5_D25_I0.8210.92
33_F36_P0.8170.92
35_K143_E0.8090.92
60_R123_L0.8020.91
13_K35_K0.7950.91
97_E100_T0.7870.91
3_I66_E0.7860.91
140_G153_K0.7860.91
146_V153_K0.7780.90
56_T60_R0.7760.90
27_A34_Y0.7740.90
104_P110_V0.7670.90
28_V34_Y0.7660.90
104_P107_D0.7540.89
83_N145_K0.7510.89
25_I29_A0.7430.88
28_V32_V0.7380.88
157_Y160_N0.7350.88
17_I38_G0.7330.87
8_G16_I0.7320.87
74_G79_D0.7320.87
57_V61_G0.7230.87
17_I154_T0.7200.86
140_G152_L0.7110.86
5_D14_I0.7030.85
79_D142_Q0.7030.85
142_Q145_K0.6950.84
6_E66_E0.6930.84
63_G102_A0.6920.84
92_T96_V0.6890.84
152_L159_F0.6860.84
69_A96_V0.6850.84
22_I133_T0.6770.83
49_A111_V0.6740.83
138_V141_G0.6730.83
108_G111_V0.6670.82
136_G143_E0.6660.82
130_A153_K0.6650.82
23_L144_I0.6580.81
7_K10_L0.6570.81
138_V143_E0.6570.81
32_V73_V0.6550.81
74_G90_T0.6540.81
105_D113_A0.6520.81
55_V128_G0.6500.80
59_V62_L0.6480.80
56_T63_G0.6460.80
26_L29_A0.6460.80
8_G15_N0.6410.79
143_E151_E0.6390.79
143_E153_K0.6380.79
62_L99_A0.6370.79
133_T138_V0.6330.79
74_G80_S0.6330.79
145_K157_Y0.6300.78
130_A139_V0.6290.78
156_N160_N0.6250.78
57_V128_G0.6230.77
71_I124_I0.6220.77
152_L161_G0.6220.77
31_G154_T0.6180.77
102_A112_A0.6150.77
74_G77_V0.6130.76
96_V122_V0.6120.76
78_Y81_I0.6110.76
5_D8_G0.6100.76
3_I10_L0.6070.76
73_V92_T0.6050.75
99_A117_P0.6040.75
58_T61_G0.6040.75
58_T165_D0.6040.75
16_I95_E0.6020.75
93_D96_V0.5990.75
55_V137_I0.5970.74
17_I21_V0.5970.74
5_D15_N0.5960.74
69_A91_I0.5920.74
42_V45_V0.5910.74
46_G50_T0.5890.73
121_D137_I0.5870.73
108_G115_D0.5870.73
81_I154_T0.5860.73
101_V135_D0.5850.73
154_T158_E0.5850.73
33_F38_G0.5850.73
23_L30_A0.5820.73
13_K16_I0.5810.72
20_L28_V0.5790.72
104_P112_A0.5790.72
151_E160_N0.5720.71
67_E70_D0.5720.71
89_V131_T0.5710.71
80_S83_N0.5680.71
57_V157_Y0.5650.70
108_G113_A0.5640.70
77_V130_A0.5630.70
148_T162_T0.5620.70
74_G124_I0.5620.70
15_N63_G0.5620.70
100_T111_V0.5600.70
62_L122_V0.5580.69
109_T113_A0.5520.69
32_V123_L0.5490.68
8_G17_I0.5470.68
72_K94_V0.5400.67
70_D94_V0.5400.67
25_I50_T0.5370.66
143_E154_T0.5330.66
75_D79_D0.5320.66
128_G140_G0.5300.65
3_I125_T0.5270.65
64_V68_L0.5270.65
141_G148_T0.5260.65
6_E21_V0.5220.64
114_P124_I0.5210.64
83_N88_E0.5200.64
80_S158_E0.5190.64
83_N154_T0.5140.63
7_K92_T0.5130.63
98_P120_Y0.5110.63
78_Y152_L0.5110.63
57_V144_I0.5110.63
9_R117_P0.5100.63
31_G36_P0.5100.63
58_T124_I0.5090.62
35_K141_G0.5080.62
60_R63_G0.5060.62
147_G159_F0.5060.62
123_L136_G0.5040.62
74_G86_Y0.5000.61
145_K154_T0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kxrA 3 0.1677 19.3 0.918 Contact Map
2m7gA 1 0.3593 5.4 0.936 Contact Map
3j1rA 5 0.1557 5.4 0.936 Contact Map
2y6tE 2 0.3593 5 0.937 Contact Map
3umnA 1 0.4731 4.6 0.938 Contact Map
4pliA 1 0.1497 4.2 0.939 Contact Map
2wwbC 1 0.2156 3.6 0.941 Contact Map
2m8rA 1 0.2275 3.5 0.942 Contact Map
2ww9C 1 0.1257 3.4 0.942 Contact Map
3j3wP 1 0.2455 3.2 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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