GREMLIN Database
COP23 - Circadian oscillating protein COP23
PFAM: PF14218 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 138 (132)
Sequences: 905 (731)
Seq/√Len: 63.6
META: 0.607

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_R91_L3.9631.00
69_V91_L3.8041.00
75_I93_F3.7531.00
42_Q46_Q3.3821.00
53_Q57_D3.0081.00
47_E50_R2.6291.00
19_T22_G2.4851.00
39_W47_E2.4741.00
35_F38_G2.2761.00
39_W43_R2.2591.00
3_F18_R2.2191.00
52_L92_L2.1981.00
49_S53_Q2.1961.00
40_T43_R2.1951.00
93_F123_E2.1591.00
96_K123_E1.9691.00
76_C86_C1.9671.00
55_Y77_V1.9611.00
53_Q56_Y1.8921.00
47_E51_R1.8721.00
124_S127_R1.8441.00
43_R47_E1.7651.00
34_F37_G1.7621.00
93_F99_Q1.7491.00
77_V90_N1.6730.99
5_G16_M1.5670.99
103_Q107_Q1.5490.99
67_G90_N1.5460.99
34_F38_G1.5170.99
44_R94_T1.5150.99
15_T29_W1.5080.98
104_V121_V1.4980.98
31_S34_F1.4780.98
74_V91_L1.4400.98
99_Q104_V1.4320.98
96_K104_V1.4120.98
39_W94_T1.4000.98
69_V74_V1.3870.97
44_R48_V1.3380.97
13_P16_M1.3040.96
52_L112_R1.2770.96
5_G14_T1.2770.96
74_V90_N1.2740.96
74_V94_T1.2710.96
51_R94_T1.2370.95
29_W48_V1.2320.95
27_I108_L1.1770.93
2_F56_Y1.1730.93
64_L105_L1.1330.92
51_R70_N1.1220.92
56_Y59_G1.1150.91
5_G52_L1.1140.91
70_N94_T1.1060.91
52_L115_G1.0980.91
65_T130_Y1.0800.90
67_G74_V1.0790.90
57_D60_L1.0440.88
34_F41_P1.0360.88
31_S120_P1.0270.88
14_T28_R1.0120.87
67_G70_N1.0060.86
67_G108_L1.0020.86
65_T102_E1.0010.86
129_V132_D0.9770.85
66_T101_P0.9610.84
2_F23_P0.9320.82
111_N118_T0.9320.82
122_N125_G0.9300.82
52_L61_L0.9230.81
52_L77_V0.9130.81
78_T83_G0.9100.80
132_D136_F0.8890.79
82_N85_S0.8830.78
64_L67_G0.8740.78
64_L109_F0.8640.77
38_G43_R0.8610.77
16_M23_P0.8590.76
5_G49_S0.8560.76
14_T25_P0.8520.76
51_R69_V0.8480.76
55_Y90_N0.8400.75
39_W44_R0.8390.75
9_S14_T0.8360.74
78_T130_Y0.8230.73
43_R108_L0.8230.73
133_L136_F0.8160.73
65_T75_I0.8140.72
13_P17_A0.8100.72
27_I44_R0.7970.71
36_G94_T0.7900.70
72_Q97_P0.7860.70
5_G9_S0.7860.70
15_T22_G0.7840.70
109_F112_R0.7810.69
35_F108_L0.7780.69
8_T46_Q0.7740.69
112_R115_G0.7540.67
120_P129_V0.7540.67
46_Q110_D0.7470.66
28_R110_D0.7450.66
29_W49_S0.7410.65
3_F16_M0.7410.65
118_T122_N0.7340.65
115_G118_T0.7320.64
71_G77_V0.7320.64
89_D98_G0.7290.64
62_K132_D0.7240.63
43_R135_P0.7220.63
73_P82_N0.7210.63
72_Q106_D0.7110.62
93_F104_V0.7030.61
66_T102_E0.7030.61
65_T85_S0.7000.61
17_A53_Q0.6990.61
15_T19_T0.6990.61
33_Y37_G0.6950.60
62_K134_K0.6920.60
31_S96_K0.6870.59
17_A89_D0.6860.59
55_Y69_V0.6690.57
13_P53_Q0.6670.57
5_G46_Q0.6660.57
12_V30_A0.6660.57
69_V77_V0.6650.57
17_A24_V0.6640.57
24_V52_L0.6610.56
29_W67_G0.6610.56
71_G126_G0.6600.56
102_E116_A0.6590.56
122_N126_G0.6560.56
61_L86_C0.6540.56
44_R51_R0.6530.56
10_N21_R0.6510.55
73_P97_P0.6500.55
129_V134_K0.6500.55
49_S57_D0.6490.55
55_Y65_T0.6470.55
10_N80_E0.6440.55
79_T83_G0.6430.54
68_V126_G0.6400.54
38_G103_Q0.6330.53
64_L89_D0.6290.53
91_L95_L0.6270.53
129_V136_F0.6230.52
51_R74_V0.6170.51
49_S61_L0.6140.51
8_T50_R0.6120.51
50_R130_Y0.6000.49
44_R95_L0.5980.49
5_G10_N0.5960.49
48_V51_R0.5960.49
5_G13_P0.5950.49
79_T82_N0.5920.49
126_G129_V0.5910.48
62_K80_E0.5910.48
56_Y60_L0.5820.47
13_P20_P0.5810.47
9_S13_P0.5800.47
8_T13_P0.5750.47
50_R54_S0.5690.46
96_K99_Q0.5690.46
2_F53_Q0.5650.45
45_C76_C0.5630.45
60_L99_Q0.5610.45
19_T24_V0.5590.45
66_T109_F0.5590.45
24_V53_Q0.5590.45
79_T121_V0.5580.45
106_D129_V0.5560.44
103_Q132_D0.5560.44
128_S132_D0.5560.44
66_T71_G0.5470.43
15_T49_S0.5460.43
59_G64_L0.5420.43
119_G122_N0.5410.43
25_P110_D0.5390.42
100_D104_V0.5380.42
111_N121_V0.5370.42
36_G54_S0.5370.42
43_R54_S0.5350.42
71_G101_P0.5300.41
46_Q49_S0.5260.41
60_L77_V0.5260.41
121_V127_R0.5250.41
101_P110_D0.5240.41
119_G125_G0.5180.40
5_G26_V0.5170.40
45_C86_C0.5160.40
13_P24_V0.5160.40
53_Q96_K0.5160.40
8_T18_R0.5160.40
128_S134_K0.5110.39
11_G47_E0.5090.39
80_E134_K0.5090.39
114_G118_T0.5060.39
55_Y78_T0.5050.39
120_P134_K0.5010.38
17_A49_S0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6zB 2 0.4565 7.2 0.936 Contact Map
3fsgA 3 0.558 6.9 0.937 Contact Map
2l2gA 1 0.3116 6.3 0.938 Contact Map
2l21A 1 0.2971 5.4 0.94 Contact Map
2gu3A 1 0.7029 4.7 0.942 Contact Map
4ml7B 1 0.4855 3.2 0.946 Contact Map
3dmkA 2 0.558 3.2 0.947 Contact Map
2vr9A 1 0.558 3.1 0.947 Contact Map
3mbeC 1 0.4348 3 0.947 Contact Map
2id5A 3 0.6304 2.9 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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