GREMLIN Database
DUF4326 - Domain of unknown function (DUF4326)
PFAM: PF14216 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 83 (76)
Sequences: 10312 (8465)
Seq/√Len: 971.0
META: 0.946

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_V78_G3.8591.00
16_G70_W2.1551.00
72_A79_D2.1521.00
20_K58_A2.0701.00
33_T36_E1.9121.00
12_D68_G1.8671.00
27_I37_V1.8551.00
36_E40_K1.7831.00
41_Y80_V1.7741.00
18_P22_G1.7161.00
35_E75_P1.7101.00
58_A61_E1.6601.00
12_D66_D1.6401.00
13_V65_K1.6291.00
42_R46_L1.5941.00
44_W48_R1.5931.00
34_R38_I1.4781.00
14_Y18_P1.4301.00
25_F44_W1.4301.00
16_G19_S1.3881.00
38_I80_V1.3811.00
66_D82_L1.3221.00
28_G33_T1.2571.00
75_P79_D1.2201.00
48_R52_D1.2181.00
9_P12_D1.2111.00
34_R74_K1.2081.00
24_P44_W1.2051.00
8_K68_G1.1951.00
14_Y70_W1.1661.00
54_E58_A1.1541.00
27_I34_R1.1501.00
51_R54_E1.1411.00
38_I75_P1.0951.00
25_F40_K1.0841.00
27_I33_T1.0551.00
11_N66_D1.0461.00
32_G36_E1.0381.00
26_R30_D1.0351.00
52_D55_L1.0241.00
6_W9_P1.0181.00
17_R22_G1.0141.00
56_L60_A1.0061.00
8_K14_Y0.9951.00
56_L59_L0.9851.00
5_G8_K0.9841.00
59_L62_L0.9671.00
20_K61_E0.9651.00
52_D56_L0.9461.00
42_R80_V0.9391.00
55_L58_A0.9371.00
14_Y19_S0.9271.00
32_G40_K0.9211.00
11_N68_G0.9201.00
32_G37_V0.9121.00
53_P57_A0.8781.00
41_Y81_L0.8691.00
36_E39_A0.8581.00
48_R51_R0.8511.00
35_E39_A0.8471.00
8_K11_N0.8251.00
28_G32_G0.8171.00
48_R53_P0.8141.00
67_L78_G0.8061.00
26_R29_K0.7981.00
43_E46_L0.7961.00
5_G9_P0.7941.00
55_L59_L0.7681.00
30_D33_T0.7651.00
19_S22_G0.7601.00
39_A75_P0.7601.00
26_R32_G0.7561.00
48_R55_L0.7531.00
57_A60_A0.7461.00
60_A63_R0.7391.00
62_L65_K0.7281.00
48_R54_E0.7201.00
73_P79_D0.7001.00
21_W81_L0.6881.00
52_D58_A0.6831.00
39_A43_E0.6721.00
30_D40_K0.6701.00
6_W12_D0.6691.00
5_G11_N0.6641.00
54_E57_A0.6631.00
8_K12_D0.6561.00
69_C76_C0.6411.00
45_L80_V0.6321.00
79_D82_L0.6301.00
6_W11_N0.6241.00
27_I30_D0.6191.00
47_G51_R0.6131.00
53_P56_L0.6121.00
34_R37_V0.6081.00
13_V21_W0.6061.00
45_L58_A0.6041.00
43_E47_G0.6041.00
40_K43_E0.6001.00
27_I32_G0.5911.00
72_A75_P0.5731.00
71_C76_C0.5731.00
5_G12_D0.5641.00
41_Y45_L0.5621.00
38_I42_R0.5591.00
44_W47_G0.5561.00
18_P70_W0.5561.00
50_E54_E0.5561.00
6_W10_P0.5491.00
21_W58_A0.5461.00
29_K32_G0.5221.00
54_E59_L0.5201.00
45_L81_L0.5151.00
33_T37_V0.5141.00
6_W70_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qmlC 1 0.253 5 0.905 Contact Map
4bpeL 1 0.9398 4.1 0.909 Contact Map
2kncB 1 0.3494 3.2 0.914 Contact Map
3iogA 1 0.4819 3.2 0.914 Contact Map
4lhdA 2 0.8675 3.1 0.914 Contact Map
1s4xA 1 0.3494 2.9 0.915 Contact Map
2kv9B 1 0.3494 2.8 0.917 Contact Map
4owtC 1 0.3855 2.7 0.917 Contact Map
4um9B 2 0 2.5 0.919 Contact Map
1ffyA 1 0.988 2.4 0.919 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.005 seconds.