GREMLIN Database
Helitron_like_N - Helitron helicase-like domain at N-terminus
PFAM: PF14214 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 188 (182)
Sequences: 3051 (2404)
Seq/√Len: 178.2
META: 0.656

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
148_H152_K5.0661.00
151_L184_A4.5181.00
115_F154_L4.2751.00
147_F174_I3.4661.00
46_N49_K3.3241.00
122_P126_R3.1731.00
91_Y95_L2.7361.00
120_K125_T2.6441.00
106_F169_A2.6211.00
156_K160_K2.3801.00
172_Y184_A2.3701.00
153_A157_D2.3481.00
130_L134_Q2.2991.00
176_F182_P2.2121.00
159_L167_V2.1761.00
41_N45_K2.1571.00
86_T91_Y2.0761.00
85_F88_S2.0401.00
155_L186_I2.0081.00
136_A143_V1.9661.00
127_L142_I1.9651.00
111_L164_F1.8411.00
52_A55_Y1.8131.00
18_L24_F1.7021.00
96_Y100_M1.6981.00
41_N44_R1.6771.00
103_V109_P1.6441.00
121_W150_K1.6231.00
93_K97_Q1.6141.00
156_K161_K1.6011.00
32_Y36_E1.5501.00
24_F28_I1.5381.00
35_I39_R1.5221.00
158_L188_L1.5191.00
6_L28_I1.5061.00
162_G166_K1.5061.00
95_L98_D1.5001.00
119_P181_L1.4931.00
117_C121_W1.4791.00
151_L186_I1.4741.00
57_G62_D1.4731.00
47_Q50_L1.4721.00
92_M173_R1.4391.00
159_L162_G1.4241.00
174_I184_A1.4191.00
51_R54_L1.3911.00
117_C124_I1.3311.00
109_P187_L1.3291.00
36_E85_F1.3211.00
31_A34_R1.3141.00
83_S94_Q1.3101.00
33_A37_S1.3031.00
99_A171_V1.2921.00
174_I182_P1.2731.00
102_I169_A1.2651.00
149_L153_A1.2551.00
118_N121_W1.2551.00
27_Y31_A1.2381.00
103_V108_K1.2301.00
155_L159_L1.2201.00
54_L57_G1.2111.00
43_I82_P1.2041.00
113_I188_L1.1921.00
147_F182_P1.1851.00
50_L55_Y1.1851.00
91_Y173_R1.1841.00
177_Q182_P1.1711.00
4_Y7_Q1.1641.00
37_S88_S1.1451.00
42_Y49_K1.1441.00
22_R26_Q1.1421.00
113_I186_I1.1401.00
63_A67_G1.1301.00
167_V170_Y1.1241.00
139_R142_I1.1151.00
42_Y46_N1.1141.00
68_D71_G1.1071.00
10_F13_D1.1021.00
176_F180_G1.0821.00
115_F151_L1.0821.00
123_E150_K1.0811.00
134_Q138_D1.0801.00
47_Q51_R1.0771.00
22_R25_Q1.0691.00
125_T136_A1.0671.00
151_L172_Y1.0661.00
26_Q29_V1.0631.00
28_I31_A1.0571.00
159_L170_Y1.0561.00
131_P134_Q1.0371.00
102_I106_F1.0320.99
154_L159_L1.0260.99
12_E138_D1.0230.99
38_N45_K0.9990.99
57_G61_Q0.9910.99
43_I46_N0.9830.99
155_L172_Y0.9830.99
29_V33_A0.9600.99
44_R47_Q0.9560.99
56_T63_A0.9540.99
128_L142_I0.9530.99
8_G11_A0.9530.99
36_E39_R0.9520.99
153_A156_K0.9510.99
67_G73_S0.9490.99
157_D161_K0.9460.99
178_K181_L0.9450.99
94_Q98_D0.9290.99
32_Y35_I0.9150.99
80_I83_S0.9130.99
56_T60_L0.9130.99
142_I150_K0.9070.99
158_L164_F0.9010.99
153_A161_K0.8960.99
81_L90_R0.8880.98
95_L102_I0.8860.98
12_E15_T0.8820.98
13_D19_L0.8820.98
98_D171_V0.8740.98
38_N42_Y0.8730.98
148_H151_L0.8710.98
36_E40_L0.8650.98
177_Q181_L0.8640.98
20_A25_Q0.8630.98
129_E135_T0.8500.98
38_N41_N0.8470.98
35_I42_Y0.8460.98
95_L99_A0.8300.98
42_Y50_L0.8280.98
101_A104_R0.8220.97
165_G169_A0.8210.97
39_R43_I0.8100.97
5_R27_Y0.8090.97
17_L24_F0.8030.97
134_Q139_R0.8010.97
37_S43_I0.7970.97
26_Q36_E0.7950.97
62_D66_N0.7950.97
60_L97_Q0.7930.97
8_G130_L0.7910.97
61_Q65_E0.7900.97
5_R12_E0.7850.97
43_I50_L0.7690.96
3_A19_L0.7660.96
53_E57_G0.7660.96
40_L43_I0.7620.96
11_A139_R0.7530.96
128_L134_Q0.7510.96
82_P90_R0.7450.96
20_A24_F0.7360.95
68_D72_A0.7360.95
14_P18_L0.7330.95
147_F151_L0.7270.95
117_C143_V0.7220.95
26_Q30_D0.7180.95
161_K164_F0.7150.94
15_T19_L0.7120.94
4_Y8_G0.7120.94
42_Y45_K0.7070.94
141_D145_R0.7010.94
98_D118_N0.6970.94
144_A149_L0.6930.93
116_T177_Q0.6910.93
46_N50_L0.6890.93
45_K49_K0.6860.93
37_S41_N0.6850.93
3_A6_L0.6770.93
18_L136_A0.6700.92
88_S186_I0.6680.92
154_L158_L0.6680.92
67_G72_A0.6630.92
17_L25_Q0.6610.92
130_L135_T0.6560.91
71_G75_L0.6540.91
62_D65_E0.6510.91
37_S40_L0.6480.91
36_E42_Y0.6470.91
74_L78_R0.6370.90
48_K52_A0.6360.90
6_L18_L0.6360.90
111_L171_V0.6340.90
145_R149_L0.6340.90
149_L152_K0.6290.90
173_R181_L0.6270.90
56_T62_D0.6250.89
119_P177_Q0.6250.89
175_E183_H0.6220.89
18_L25_Q0.6210.89
6_L10_F0.6200.89
53_E56_T0.6170.89
48_K73_S0.6140.89
162_G167_V0.6110.88
74_L107_G0.6080.88
92_M95_L0.6070.88
51_R55_Y0.6040.88
63_A66_N0.6020.88
34_R38_N0.6020.88
28_I32_Y0.6010.87
46_N55_Y0.6010.87
157_D163_I0.5950.87
132_G135_T0.5880.86
80_I90_R0.5880.86
34_R40_L0.5870.86
23_L116_T0.5860.86
57_G63_A0.5860.86
87_G92_M0.5800.86
7_Q10_F0.5730.85
95_L137_A0.5730.85
5_R8_G0.5710.85
102_I140_P0.5700.85
7_Q18_L0.5690.84
3_A7_Q0.5690.84
60_L106_F0.5670.84
39_R42_Y0.5650.84
50_L53_E0.5650.84
150_K173_R0.5650.84
67_G70_D0.5640.84
34_R37_S0.5610.84
12_E17_L0.5600.84
33_A36_E0.5600.84
115_F184_A0.5590.83
10_F18_L0.5580.83
167_V188_L0.5580.83
56_T64_L0.5580.83
76_G118_N0.5570.83
102_I171_V0.5550.83
96_Y157_D0.5550.83
106_F168_V0.5540.83
137_A151_L0.5510.83
8_G13_D0.5500.82
37_S44_R0.5490.82
175_E185_H0.5490.82
31_A38_N0.5480.82
128_L131_P0.5480.82
27_Y34_R0.5460.82
83_S89_P0.5440.82
109_P113_I0.5430.82
124_I146_V0.5400.81
8_G12_E0.5390.81
31_A35_I0.5390.81
144_A176_F0.5380.81
56_T66_N0.5380.81
76_G113_I0.5370.81
103_V187_L0.5360.81
45_K66_N0.5360.81
87_G180_G0.5360.81
33_A155_L0.5350.81
13_D29_V0.5300.80
35_I40_L0.5290.80
138_D142_I0.5270.80
21_G25_Q0.5270.80
22_R27_Y0.5250.79
19_L22_R0.5240.79
117_C173_R0.5220.79
117_C181_L0.5220.79
76_G112_F0.5220.79
183_H187_L0.5210.79
65_E74_L0.5200.79
66_N72_A0.5190.79
97_Q104_R0.5190.79
21_G24_F0.5190.79
13_D17_L0.5190.79
158_L167_V0.5190.79
109_P117_C0.5160.78
8_G28_I0.5130.78
104_R112_F0.5050.77
23_L26_Q0.5040.77
10_F28_I0.5030.77
26_Q34_R0.5010.76
165_G178_K0.5010.76
74_L135_T0.5000.76
87_G124_I0.5000.76
5_R17_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1l2mA 1 0.3138 23.3 0.934 Contact Map
2hwtA 1 0.2394 9.8 0.944 Contact Map
2hw0A 1 0.2872 7.1 0.948 Contact Map
1m55A 1 0.4681 4.5 0.952 Contact Map
3bxwB 2 0.2819 3.3 0.955 Contact Map
1ny71 4 0.3351 3.1 0.956 Contact Map
1h1jS 1 0.234 2.6 0.958 Contact Map
3mwmA 2 0.4149 2.5 0.958 Contact Map
4pp4A 1 0.6383 2.4 0.958 Contact Map
2fe3A 2 0.4894 2.4 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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