GREMLIN Database
DUF4320 - Domain of unknown function (DUF4320)
PFAM: PF14208 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 118 (118)
Sequences: 691 (482)
Seq/√Len: 44.4
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_K117_W3.3191.00
21_K25_D3.2311.00
76_I82_F3.1191.00
32_V82_F2.8351.00
27_F53_K2.8251.00
35_A64_W2.2601.00
9_A13_N2.1671.00
11_A15_F2.1031.00
28_A86_L2.0100.99
33_R36_E2.0090.99
42_G95_F2.0000.99
4_A8_L1.9300.99
48_R51_E1.9280.99
33_R114_E1.8900.99
49_F53_K1.7770.98
24_L86_L1.7760.98
34_E112_K1.7480.98
4_A11_A1.7420.98
39_G113_S1.7060.98
51_E54_E1.6650.97
66_A70_N1.6490.97
22_Q29_D1.6250.97
30_E60_P1.5790.96
5_M8_L1.5510.96
38_A44_E1.4720.95
36_E111_G1.4340.94
40_R117_W1.4160.93
44_E47_A1.4020.93
10_L105_L1.3970.93
32_V76_I1.3760.92
113_S118_K1.3350.91
35_A82_F1.3240.91
35_A76_I1.3230.91
69_F72_K1.3080.90
4_A7_V1.3000.90
41_V76_I1.2830.89
30_E79_G1.2750.89
58_L88_Y1.2730.89
49_F62_I1.2610.89
53_K59_D1.2340.87
9_A15_F1.1970.86
22_Q26_T1.1670.84
90_Y97_P1.1660.84
70_N74_G1.1650.84
105_L111_G1.1460.83
79_G112_K1.1410.83
35_A84_V1.1360.83
87_T106_T1.1270.82
25_D28_A1.1260.82
68_Y71_G1.1260.82
16_P24_L1.1190.82
34_E38_A1.1020.81
47_A51_E1.0840.80
85_T108_K1.0760.79
6_L98_F1.0670.79
8_L22_Q1.0660.78
35_A48_R1.0630.78
7_V14_V1.0630.78
8_L11_A1.0610.78
50_N54_E1.0500.77
20_A26_T1.0490.77
31_L71_G1.0480.77
33_R37_I1.0410.77
27_F64_W1.0310.76
47_A53_K1.0280.76
78_L116_Y1.0020.74
56_T86_L0.9980.74
80_D103_I0.9880.73
5_M12_V0.9850.73
59_D62_I0.9680.71
67_T71_G0.9260.68
35_A41_V0.9260.68
70_N73_T0.9230.68
79_G101_F0.9200.67
78_L82_F0.8920.65
66_A69_F0.8830.64
32_V56_T0.8770.64
68_Y72_K0.8600.62
2_L61_T0.8590.62
40_R44_E0.8570.62
1_V36_E0.8550.62
23_Q44_E0.8540.62
6_L12_V0.8510.61
41_V64_W0.8510.61
41_V84_V0.8390.60
1_V5_M0.8370.60
33_R84_V0.8210.59
28_A107_A0.8210.59
7_V18_F0.8140.58
75_K106_T0.8120.58
26_T32_V0.7960.56
95_F101_F0.7930.56
53_K62_I0.7930.56
71_G74_G0.7860.55
114_E118_K0.7810.55
44_E48_R0.7760.54
46_T50_N0.7750.54
20_A24_L0.7710.54
36_E39_G0.7640.53
40_R75_K0.7640.53
43_S118_K0.7620.53
37_I64_W0.7580.53
9_A114_E0.7560.52
3_V50_N0.7540.52
8_L13_N0.7420.51
82_F112_K0.7380.51
14_V49_F0.7340.50
31_L49_F0.7320.50
36_E115_V0.7300.50
97_P101_F0.7270.50
52_L55_Q0.7230.49
34_E60_P0.7200.49
49_F86_L0.7100.48
79_G82_F0.7030.47
3_V11_A0.7020.47
16_P109_A0.7010.47
47_A87_T0.6960.47
3_V7_V0.6960.47
3_V90_Y0.6820.45
85_T106_T0.6790.45
96_G116_Y0.6770.45
16_P20_A0.6750.45
7_V11_A0.6700.44
17_V107_A0.6650.44
83_T97_P0.6640.44
55_Q98_F0.6610.43
102_P117_W0.6590.43
47_A50_N0.6590.43
72_K80_D0.6560.43
84_V114_E0.6560.43
30_E64_W0.6300.40
57_G60_P0.6260.40
26_T37_I0.6240.40
17_V20_A0.6180.39
8_L16_P0.6060.38
54_E87_T0.6060.38
24_L62_I0.6050.38
28_A93_G0.6050.38
3_V6_L0.5970.37
4_A69_F0.5940.37
79_G94_L0.5910.37
18_F21_K0.5890.37
26_T29_D0.5890.37
30_E35_A0.5880.36
13_N82_F0.5830.36
47_A72_K0.5800.36
9_A24_L0.5790.36
109_A114_E0.5790.36
57_G82_F0.5790.36
37_I109_A0.5760.35
41_V82_F0.5750.35
84_V115_V0.5740.35
72_K89_T0.5620.34
39_G78_L0.5600.34
83_T118_K0.5590.34
48_R52_L0.5560.34
84_V88_Y0.5540.33
40_R47_A0.5530.33
70_N75_K0.5520.33
7_V46_T0.5520.33
8_L15_F0.5520.33
63_S71_G0.5500.33
67_T70_N0.5490.33
63_S69_F0.5490.33
5_M58_L0.5460.33
87_T110_S0.5450.33
58_L67_T0.5420.32
43_S59_D0.5410.32
2_L83_T0.5300.31
43_S46_T0.5300.31
80_D89_T0.5290.31
27_F86_L0.5270.31
1_V32_V0.5200.31
7_V78_L0.5190.31
89_T102_P0.5120.30
65_S70_N0.5110.30
30_E48_R0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uiiA 2 0.0763 5.5 0.923 Contact Map
3s8fB 1 0.9492 4.4 0.927 Contact Map
2wb7A 1 0.7119 4.3 0.928 Contact Map
4lebA 1 0.6356 3.8 0.929 Contact Map
2l02A 2 0.6695 3.3 0.932 Contact Map
3l81A 1 0.3814 3.3 0.932 Contact Map
2ksdA 1 0.2203 2.9 0.933 Contact Map
1ftpA 2 0.7119 2.8 0.934 Contact Map
2qo4A 1 0.7034 2.7 0.934 Contact Map
4bgnA 3 0.2627 2.7 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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