GREMLIN Database
Cys_rich_CPCC - Cysteine-rich CPCC
PFAM: PF14206 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (72)
Sequences: 3613 (2893)
Seq/√Len: 340.9
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D48_R2.9151.00
2_P9_L2.8951.00
18_Y27_E2.6731.00
64_F67_H2.6351.00
48_R51_R2.0841.00
52_E56_R2.0211.00
36_P48_R2.0101.00
60_C64_F1.9951.00
13_E17_S1.9751.00
57_F62_E1.8971.00
53_N57_F1.6791.00
62_E65_L1.6631.00
61_E64_F1.5741.00
20_I27_E1.5501.00
45_V50_A1.5441.00
35_D38_V1.5371.00
25_F59_A1.5311.00
10_T22_P1.4821.00
18_Y30_G1.4741.00
45_V61_E1.4121.00
45_V60_C1.3331.00
8_Y54_F1.3051.00
52_E55_A1.2811.00
12_D19_E1.2771.00
31_Q38_V1.2691.00
4_P11_L1.2391.00
56_R62_E1.2331.00
25_F67_H1.2271.00
34_D39_R1.2261.00
25_F68_V1.1681.00
25_F64_F1.1511.00
28_D33_L1.1151.00
16_G28_D1.0841.00
59_A68_V1.0711.00
5_C47_L1.0681.00
7_G51_R1.0171.00
39_R49_E0.9541.00
57_F65_L0.9451.00
59_A65_L0.9301.00
32_Q42_A0.9281.00
14_R17_S0.9231.00
3_C6_C0.9211.00
44_G64_F0.9191.00
18_Y41_G0.9171.00
31_Q40_G0.9111.00
10_T23_V0.9091.00
2_P7_G0.9081.00
17_S33_L0.8911.00
11_L28_D0.8791.00
29_D42_A0.8641.00
49_E52_E0.8631.00
8_Y23_V0.8561.00
32_Q38_V0.8321.00
20_I25_F0.8231.00
29_D43_N0.8151.00
31_Q36_P0.8061.00
9_L51_R0.8051.00
2_P51_R0.7911.00
30_G34_D0.7731.00
23_V58_G0.7380.99
32_Q41_G0.7370.99
21_C24_C0.7360.99
40_G46_S0.7320.99
4_P33_L0.7090.99
45_V53_N0.7090.99
26_W50_A0.7010.99
67_H72_L0.7010.99
9_L12_D0.6950.99
31_Q35_D0.6870.99
23_V54_F0.6870.99
29_D32_Q0.6770.99
35_D48_R0.6700.99
32_Q40_G0.6700.99
33_L39_R0.6590.99
11_L16_G0.6490.99
13_E16_G0.6370.98
25_F60_C0.6340.98
53_N58_G0.6290.98
43_N46_S0.6270.98
12_D73_P0.6270.98
14_R28_D0.6210.98
70_P74_E0.6160.98
18_Y42_A0.6150.98
16_G30_G0.6130.98
44_G61_E0.6020.98
38_V45_V0.6010.98
11_L17_S0.5980.98
40_G45_V0.5970.98
9_L23_V0.5960.98
23_V69_R0.5950.98
39_R46_S0.5900.97
65_L68_V0.5890.97
9_L55_A0.5750.97
4_P28_D0.5750.97
31_Q42_A0.5720.97
70_P73_P0.5690.97
31_Q34_D0.5580.97
11_L19_E0.5560.96
50_A53_N0.5510.96
34_D37_D0.5480.96
2_P55_A0.5450.96
23_V51_R0.5370.96
5_C54_F0.5360.96
14_R32_Q0.5350.96
50_A60_C0.5140.95
52_E62_E0.5110.94
11_L33_L0.5010.94
54_F58_G0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pwfA 4 0.4267 81.7 0.826 Contact Map
1lkoA 3 0.48 79.4 0.83 Contact Map
1yuzA 2 0.4133 77.4 0.833 Contact Map
1s24A 1 0.48 70.2 0.842 Contact Map
2kn9A 1 0.5067 69.1 0.843 Contact Map
1dx8A 1 0.6267 69 0.843 Contact Map
1vq8Z 1 0.6133 66.1 0.847 Contact Map
4tpuA 3 0.4533 62.6 0.85 Contact Map
1yk4A 1 0.4533 54.9 0.857 Contact Map
2v3bB 1 0.4533 54.9 0.857 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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