GREMLIN Database
DUF4317 - Domain of unknown function (DUF4317)
PFAM: PF14199 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 371 (369)
Sequences: 1055 (694)
Seq/√Len: 36.1
META: 0.645

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_E199_S6.5791.00
34_I107_D5.8901.00
105_F109_I5.1201.00
29_D33_E5.0411.00
60_T189_G4.7771.00
196_N201_D3.9361.00
168_D175_K3.9261.00
125_H149_E3.8261.00
219_F223_V3.6771.00
60_T154_S3.6231.00
78_Q84_T3.5161.00
37_E103_E3.4741.00
148_Y191_L3.4161.00
126_D150_Y3.1931.00
71_E196_N3.1201.00
89_M93_D2.9781.00
79_E203_H2.7891.00
107_D111_E2.7801.00
123_L153_C2.7531.00
355_R361_P2.6991.00
12_R126_D2.6031.00
86_E90_A2.5051.00
95_K149_E2.4861.00
358_L362_V2.3621.00
177_R180_D2.3280.99
85_Q192_F2.2870.99
39_K99_D2.1990.99
335_V339_V2.1780.99
8_E198_R2.1590.99
134_T138_E2.1550.99
20_I124_I2.1400.99
297_E301_E2.1300.99
267_I319_A2.0980.99
2_N5_E2.0980.99
9_I191_L2.0740.99
260_H328_F2.0480.99
134_T140_L2.0130.98
295_V299_K2.0120.98
262_N293_S1.9820.98
334_D340_S1.9710.98
334_D343_R1.9360.98
82_G86_E1.9190.98
362_V366_V1.9150.98
102_L106_Y1.9150.98
63_G69_L1.8980.98
328_F368_V1.8730.98
283_K308_E1.8500.97
120_L174_F1.8480.97
270_H279_L1.8410.97
191_L206_L1.8320.97
140_L143_A1.8180.97
287_K304_E1.8170.97
95_K125_H1.7900.97
85_Q89_M1.7460.96
266_M289_I1.7380.96
307_F315_A1.7290.96
242_I290_L1.7160.96
69_L206_L1.7150.96
217_P221_E1.6920.95
24_C39_K1.6710.95
205_V224_L1.6300.94
207_Y217_P1.6290.94
62_S208_Y1.6200.94
177_R181_W1.6010.94
122_L174_F1.5980.94
330_I368_V1.5930.94
159_K184_E1.5730.93
6_I10_R1.5610.93
23_I145_D1.5380.93
250_D296_P1.5330.92
79_E85_Q1.5270.92
60_T152_L1.5260.92
75_P83_G1.5250.92
215_P231_T1.5130.92
132_T140_L1.4830.91
358_L366_V1.4740.91
73_E204_S1.4720.91
337_I347_V1.4710.91
120_L183_V1.4660.91
30_G117_G1.4630.91
352_I357_C1.4520.90
211_K214_E1.4420.90
41_S44_S1.4280.89
12_R150_Y1.4210.89
128_Y195_F1.4170.89
79_E83_G1.4010.88
79_E82_G1.3790.88
6_I65_L1.3740.88
7_A10_R1.3730.87
251_C256_V1.3720.87
75_P85_Q1.3690.87
16_D50_Q1.3600.87
5_E196_N1.3530.87
192_F202_I1.3410.86
350_R353_D1.3390.86
16_D47_E1.3310.86
356_K365_D1.3280.86
25_G38_F1.3180.85
82_G202_I1.3060.85
89_M92_R1.3000.84
26_C106_Y1.2990.84
87_F101_L1.2980.84
77_E80_E1.2960.84
167_Y181_W1.2790.83
168_D171_E1.2780.83
359_V362_V1.2730.83
12_R17_N1.2710.83
152_L191_L1.2710.83
230_M317_L1.2650.83
195_F198_R1.2580.82
235_Q321_N1.2550.82
82_G203_H1.2500.82
28_V121_I1.2490.82
132_T143_A1.2470.82
343_R346_L1.2420.82
90_A104_E1.2330.81
89_M192_F1.2230.81
29_D35_I1.2200.80
133_K139_E1.2170.80
22_R39_K1.2160.80
213_K231_T1.2090.80
52_K56_I1.2080.80
344_L361_P1.1950.79
322_L328_F1.1900.79
163_P176_N1.1900.79
24_C102_L1.1900.79
4_K137_G1.1830.78
72_L205_V1.1780.78
257_Q328_F1.1760.78
13_F154_S1.1760.78
171_E175_K1.1750.78
209_T212_A1.1540.76
10_R58_K1.1520.76
150_Y175_K1.1510.76
133_K143_A1.1460.76
270_H275_E1.1450.76
334_D341_P1.1430.76
154_S189_G1.1380.75
109_I219_F1.1350.75
36_S174_F1.1340.75
75_P82_G1.1280.75
74_F85_Q1.1240.75
334_D363_D1.1140.74
38_F120_L1.1090.74
134_T141_E1.1060.73
230_M238_T1.0960.73
83_G203_H1.0910.72
16_D337_I1.0910.72
72_L224_L1.0900.72
234_E246_T1.0860.72
20_I126_D1.0830.72
237_E240_Q1.0830.72
282_D285_D1.0780.71
136_D142_D1.0740.71
232_A321_N1.0740.71
194_A204_S1.0720.71
327_S338_K1.0700.71
21_T125_H1.0690.71
130_V198_R1.0640.70
210_K313_E1.0640.70
248_G255_V1.0620.70
19_T126_D1.0540.70
243_V247_L1.0450.69
187_E216_H1.0430.69
268_E286_V1.0370.68
128_Y198_R1.0320.68
262_N292_E1.0220.67
301_E305_E1.0110.66
112_N222_A1.0100.66
207_Y215_P1.0040.66
46_P358_L0.9920.65
174_F188_L0.9920.65
57_F126_D0.9830.64
57_F124_I0.9800.64
73_E76_L0.9770.64
42_F45_L0.9770.64
2_N13_F0.9690.63
130_V199_S0.9660.63
214_E217_P0.9620.62
123_L277_E0.9620.62
275_E286_V0.9610.62
214_E269_E0.9570.62
347_V360_I0.9550.62
265_E269_E0.9490.61
10_R371_I0.9450.61
337_I362_V0.9430.61
87_F108_K0.9390.61
201_D204_S0.9320.60
14_K137_G0.9290.60
35_I122_L0.9260.59
60_T191_L0.9200.59
220_I328_F0.9200.59
283_K304_E0.9170.59
220_I228_P0.9150.59
192_F248_G0.9050.58
150_Y166_G0.9020.57
344_L356_K0.8990.57
65_L71_E0.8990.57
74_F192_F0.8950.57
94_S101_L0.8930.57
242_I317_L0.8910.57
331_K336_V0.8890.56
22_R147_V0.8850.56
47_E51_E0.8810.56
340_S349_T0.8770.55
32_K106_Y0.8760.55
242_I307_F0.8720.55
196_N206_L0.8670.54
177_R182_V0.8640.54
253_Y295_V0.8590.54
257_Q260_H0.8510.53
266_M279_L0.8500.53
336_V343_R0.8490.53
263_L319_A0.8480.53
38_F122_L0.8440.52
81_E86_E0.8400.52
24_C352_I0.8400.52
65_L155_I0.8390.52
7_A207_Y0.8380.52
267_I301_E0.8370.52
328_F344_L0.8360.52
214_E264_N0.8360.52
71_E201_D0.8340.52
105_F153_C0.8330.52
62_S96_L0.8320.51
12_R19_T0.8310.51
149_E179_R0.8300.51
133_K212_A0.8270.51
34_I103_E0.8240.51
117_G126_D0.8240.51
188_L216_H0.8220.51
95_K127_A0.8200.50
119_Y198_R0.8160.50
230_M323_I0.8150.50
153_C190_F0.8130.50
346_L349_T0.8130.50
24_C99_D0.8130.50
82_G192_F0.8130.50
259_I294_G0.8090.49
212_A233_A0.8070.49
138_E243_V0.8070.49
103_E209_T0.8060.49
130_V146_E0.8050.49
151_I350_R0.8030.49
337_I366_V0.8010.49
213_K233_A0.7980.48
87_F90_A0.7950.48
151_I220_I0.7920.48
23_I326_K0.7910.48
208_Y366_V0.7880.48
127_A147_V0.7850.47
93_D172_N0.7820.47
76_L79_E0.7810.47
53_Y57_F0.7780.47
195_F200_A0.7770.47
84_T224_L0.7750.46
182_V253_Y0.7740.46
260_H322_L0.7700.46
223_V337_I0.7700.46
21_T95_K0.7690.46
21_T43_L0.7680.46
337_I358_L0.7660.46
337_I346_L0.7650.46
249_E288_R0.7630.45
160_L181_W0.7630.45
100_E200_A0.7620.45
109_I155_I0.7580.45
61_L69_L0.7580.45
119_Y157_P0.7570.45
108_K223_V0.7530.45
324_D327_S0.7520.44
317_L332_T0.7520.44
13_F20_I0.7510.44
307_F316_E0.7500.44
54_L243_V0.7500.44
129_D144_S0.7420.44
247_L256_V0.7410.44
79_E202_I0.7400.43
65_L206_L0.7400.43
146_E200_A0.7390.43
19_T150_Y0.7370.43
60_T69_L0.7360.43
32_K117_G0.7340.43
160_L179_R0.7340.43
355_R358_L0.7340.43
238_T255_V0.7320.43
95_K234_E0.7310.43
158_V180_D0.7310.43
112_N223_V0.7310.43
6_I9_I0.7290.42
166_G177_R0.7290.42
234_E356_K0.7280.42
73_E80_E0.7270.42
76_L203_H0.7270.42
19_T359_V0.7270.42
52_K118_N0.7250.42
28_V110_I0.7240.42
114_D216_H0.7230.42
2_N55_E0.7230.42
301_E304_E0.7220.42
134_T148_Y0.7210.42
82_G90_A0.7200.42
192_F203_H0.7190.42
252_D317_L0.7180.42
83_G87_F0.7120.41
255_V295_V0.7120.41
321_N358_L0.7120.41
50_Q58_K0.7110.41
103_E288_R0.7070.41
11_K304_E0.7050.40
312_G315_A0.7040.40
189_G277_E0.7010.40
39_K44_S0.7000.40
231_T355_R0.7000.40
33_E147_V0.6960.40
224_L362_V0.6920.39
226_C326_K0.6910.39
110_I121_I0.6910.39
92_R200_A0.6900.39
13_F275_E0.6890.39
192_F197_D0.6850.39
1_M10_R0.6830.39
103_E107_D0.6830.39
238_T242_I0.6820.39
324_D361_P0.6820.39
70_L232_A0.6810.38
6_I69_L0.6810.38
360_I369_N0.6790.38
257_Q344_L0.6770.38
357_C363_D0.6750.38
283_K289_I0.6730.38
281_L289_I0.6720.38
292_E320_S0.6700.38
53_Y220_I0.6680.37
85_Q115_Y0.6680.37
166_G175_K0.6680.37
201_D225_G0.6680.37
211_K215_P0.6680.37
70_L209_T0.6660.37
81_E237_E0.6650.37
10_R14_K0.6640.37
6_I56_I0.6630.37
35_I51_E0.6630.37
283_K322_L0.6620.37
262_N266_M0.6610.37
243_V366_V0.6600.37
90_A98_D0.6590.37
27_Y269_E0.6590.37
91_L105_F0.6590.37
51_E54_L0.6580.37
6_I275_E0.6570.37
329_E344_L0.6530.36
337_I368_V0.6510.36
300_L307_F0.6510.36
254_E366_V0.6500.36
122_L156_C0.6490.36
109_I133_K0.6490.36
15_P51_E0.6490.36
263_L289_I0.6480.36
206_L307_F0.6460.36
27_Y106_Y0.6460.36
110_I144_S0.6460.36
15_P23_I0.6450.36
100_E104_E0.6390.35
196_N290_L0.6390.35
22_R358_L0.6380.35
80_E151_I0.6380.35
254_E280_T0.6370.35
232_A236_K0.6360.35
263_L347_V0.6360.35
80_E197_D0.6340.35
347_V359_V0.6320.35
72_L226_C0.6320.35
346_L367_E0.6310.34
106_Y110_I0.6290.34
129_D157_P0.6280.34
13_F47_E0.6280.34
312_G317_L0.6250.34
357_C362_V0.6240.34
10_R340_S0.6200.34
333_P345_D0.6190.33
161_S182_V0.6170.33
34_I111_E0.6170.33
8_E130_V0.6160.33
234_E304_E0.6150.33
75_P218_E0.6140.33
268_E298_E0.6140.33
152_L219_F0.6110.33
63_G180_D0.6110.33
241_E255_V0.6100.33
215_P250_D0.6090.33
196_N204_S0.6090.33
13_F46_P0.6090.33
205_V231_T0.6090.33
86_E98_D0.6080.33
155_I158_V0.6070.33
180_D183_V0.6040.32
151_I205_V0.6030.32
75_P203_H0.6030.32
8_E129_D0.6020.32
57_F319_A0.6020.32
136_D139_E0.6010.32
124_I152_L0.6010.32
53_Y56_I0.6000.32
202_I322_L0.5990.32
266_M286_V0.5970.32
79_E84_T0.5970.32
145_D148_Y0.5970.32
5_E71_E0.5970.32
9_I253_Y0.5970.32
156_C195_F0.5970.32
345_D361_P0.5960.32
81_E90_A0.5960.32
140_L145_D0.5950.32
65_L280_T0.5940.32
289_I323_I0.5940.32
85_Q205_V0.5910.31
224_L337_I0.5910.31
108_K225_G0.5910.31
130_V134_T0.5910.31
77_E358_L0.5900.31
106_Y211_K0.5900.31
188_L219_F0.5890.31
85_Q203_H0.5890.31
262_N289_I0.5890.31
116_E185_A0.5870.31
20_I154_S0.5870.31
153_C267_I0.5860.31
78_Q83_G0.5850.31
340_S361_P0.5850.31
205_V223_V0.5840.31
73_E81_E0.5840.31
8_E195_F0.5820.31
8_E157_P0.5810.31
242_I264_N0.5810.31
268_E326_K0.5810.31
18_C43_L0.5800.31
287_K300_L0.5790.30
27_Y110_I0.5770.30
253_Y363_D0.5760.30
166_G185_A0.5750.30
90_A93_D0.5750.30
75_P79_E0.5750.30
58_K176_N0.5740.30
56_I161_S0.5730.30
52_K179_R0.5730.30
200_A249_E0.5730.30
186_P352_I0.5710.30
211_K335_V0.5710.30
92_R119_Y0.5700.30
21_T127_A0.5690.30
236_K239_F0.5680.30
161_S181_W0.5670.30
166_G181_W0.5660.30
101_L151_I0.5660.30
258_N293_S0.5650.29
204_S226_C0.5650.29
252_D319_A0.5630.29
91_L96_L0.5630.29
296_P299_K0.5630.29
317_L330_I0.5630.29
16_D265_E0.5620.29
40_E44_S0.5620.29
52_K129_D0.5620.29
76_L80_E0.5620.29
281_L286_V0.5610.29
93_D98_D0.5610.29
9_I127_A0.5610.29
146_E150_Y0.5600.29
236_K368_V0.5600.29
215_P220_I0.5600.29
57_F132_T0.5590.29
335_V364_E0.5580.29
309_E353_D0.5560.29
157_P195_F0.5560.29
211_K289_I0.5540.29
94_S98_D0.5540.29
149_E205_V0.5540.29
22_R66_G0.5530.29
29_D118_N0.5530.29
154_S197_D0.5510.28
129_D198_R0.5500.28
3_K53_Y0.5470.28
115_Y201_D0.5470.28
343_R364_E0.5470.28
100_E112_N0.5460.28
109_I223_V0.5460.28
335_V360_I0.5460.28
291_E297_E0.5430.28
22_R46_P0.5420.28
201_D319_A0.5410.28
362_V365_D0.5400.28
330_I349_T0.5400.28
42_F57_F0.5390.28
231_T361_P0.5390.28
337_I349_T0.5380.28
70_L159_K0.5380.28
92_R340_S0.5380.28
58_K297_E0.5370.27
14_K17_N0.5360.27
171_E227_E0.5360.27
265_E292_E0.5360.27
236_K363_D0.5350.27
296_P336_V0.5350.27
8_E28_V0.5340.27
172_N241_E0.5330.27
114_D215_P0.5330.27
8_E128_Y0.5320.27
46_P93_D0.5310.27
46_P56_I0.5310.27
331_K356_K0.5310.27
3_K64_T0.5310.27
115_Y267_I0.5310.27
262_N267_I0.5300.27
172_N183_V0.5300.27
337_I367_E0.5290.27
107_D355_R0.5280.27
58_K65_L0.5270.27
20_I55_E0.5270.27
131_P206_L0.5260.27
127_A248_G0.5250.27
229_P303_F0.5240.27
151_I166_G0.5240.27
284_K287_K0.5240.27
108_K211_K0.5240.27
357_C361_P0.5230.26
53_Y158_V0.5220.26
284_K304_E0.5210.26
168_D174_F0.5210.26
166_G219_F0.5210.26
147_V296_P0.5210.26
320_S366_V0.5200.26
208_Y354_G0.5190.26
237_E294_G0.5190.26
207_Y219_F0.5180.26
126_D216_H0.5170.26
48_E291_E0.5160.26
137_G212_A0.5160.26
35_I120_L0.5130.26
233_A303_F0.5110.26
35_I158_V0.5110.26
11_K14_K0.5110.26
9_I148_Y0.5080.25
149_E347_V0.5080.25
70_L118_N0.5080.25
220_I233_A0.5080.25
245_E350_R0.5070.25
356_K363_D0.5060.25
151_I189_G0.5050.25
58_K97_K0.5040.25
126_D270_H0.5030.25
119_Y155_I0.5030.25
109_I114_D0.5020.25
14_K50_Q0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uwsA 1 0.2722 43.2 0.972 Contact Map
3ja7A 5 0.2749 29.6 0.974 Contact Map
3fhfA 1 0.3935 11.5 0.979 Contact Map
2kzfA 1 0.2291 9.2 0.979 Contact Map
4kcze 1 0.1941 7.6 0.98 Contact Map
3nr7A 2 0.1914 7.5 0.98 Contact Map
4qs1e 1 0.1941 7.4 0.98 Contact Map
1gpjA 2 0.159 7.1 0.98 Contact Map
3zzpA 1 0.1671 7 0.981 Contact Map
5a49A 2 0.2022 7 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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