GREMLIN Database
TnpV - Transposon-encoded protein TnpV
PFAM: PF14198 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (111)
Sequences: 4361 (2584)
Seq/√Len: 245.3
META: 0.937

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_E95_R3.4911.00
4_L9_Y3.3851.00
3_T12_N3.2061.00
78_E102_R2.8361.00
31_R55_H2.7791.00
41_V45_N2.6111.00
26_K30_M2.4001.00
88_D91_E2.3791.00
83_Q87_E2.3591.00
46_L51_K2.2921.00
25_G60_D2.1111.00
33_R37_E1.9201.00
5_V10_I1.8921.00
69_R73_Q1.8091.00
91_E94_G1.7891.00
98_N102_R1.7751.00
4_L7_D1.6921.00
1_T12_N1.6161.00
44_T48_L1.5861.00
27_Y30_M1.5181.00
22_R61_E1.5091.00
60_D64_E1.4941.00
89_Q93_V1.4241.00
108_L112_I1.4151.00
104_E108_L1.3941.00
45_N48_L1.3941.00
35_L42_L1.3571.00
28_G60_D1.3341.00
22_R57_A1.3111.00
26_K104_E1.3091.00
100_R104_E1.2671.00
24_I28_G1.2651.00
66_R110_E1.2321.00
90_M93_V1.2311.00
16_P50_G1.2291.00
66_R69_R1.2251.00
30_M108_L1.2101.00
75_A96_M1.1801.00
1_T9_Y1.1781.00
29_R32_L1.1751.00
61_E65_E1.1741.00
39_R42_L1.1611.00
103_A107_V1.1461.00
67_F71_V1.1221.00
42_L45_N1.1201.00
41_V48_L1.1131.00
55_H59_I1.0831.00
6_G10_I1.0691.00
43_Y47_L1.0671.00
78_E99_I1.0591.00
1_T4_L1.0551.00
31_R34_Y1.0541.00
27_Y108_L1.0481.00
58_E62_Q1.0391.00
95_R99_I1.0311.00
67_F104_E1.0291.00
72_K75_A1.0231.00
80_V99_I1.0131.00
53_N57_A1.0111.00
67_F100_R0.9961.00
72_K76_E0.9941.00
92_W96_M0.9931.00
68_E71_V0.9701.00
51_K54_E0.9671.00
64_E67_F0.9621.00
66_R111_L0.9511.00
73_Q77_A0.9501.00
74_M99_I0.9451.00
66_R70_L0.9411.00
40_P44_T0.9401.00
32_L43_Y0.9341.00
99_I102_R0.9301.00
24_I56_L0.9281.00
62_Q66_R0.9251.00
32_L44_T0.9191.00
57_A61_E0.9111.00
45_N49_S0.9021.00
24_I57_A0.8991.00
32_L35_L0.8560.99
31_R35_L0.8500.99
78_E95_R0.8430.99
63_A107_V0.8400.99
42_L46_L0.8180.99
33_R36_K0.8160.99
32_L36_K0.8060.99
27_Y67_F0.8060.99
73_Q76_E0.8000.99
1_T5_V0.7960.99
74_M102_R0.7650.99
29_R33_R0.7560.98
93_V97_N0.7550.98
15_L18_E0.7520.98
89_Q92_W0.7470.98
80_V95_R0.7430.98
31_R56_L0.7370.98
80_V84_L0.7320.98
75_A81_T0.7180.98
85_K92_W0.7130.98
34_Y38_H0.7050.98
65_E69_R0.7050.98
82_E85_K0.7040.98
70_L106_I0.6970.97
5_V12_N0.6960.97
74_M103_A0.6850.97
17_E20_E0.6740.97
34_Y42_L0.6680.97
22_R53_N0.6620.97
81_T84_L0.6610.97
55_H58_E0.6590.96
57_A60_D0.6510.96
67_F107_V0.6510.96
27_Y104_E0.6430.96
18_E54_E0.6420.96
71_V96_M0.6400.96
17_E21_E0.6360.96
50_G54_E0.6350.96
64_E68_E0.6330.96
71_V100_R0.6320.96
101_N104_E0.6270.95
3_T10_I0.6260.95
75_A79_G0.6250.95
98_N101_N0.6160.95
70_L74_M0.6100.95
18_E21_E0.6080.94
62_Q69_R0.6060.94
67_F103_A0.6060.94
35_L55_H0.6050.94
26_K29_R0.6030.94
9_Y12_N0.6020.94
62_Q111_L0.5990.94
5_V9_Y0.5970.94
71_V75_A0.5960.94
3_T14_T0.5950.94
70_L73_Q0.5940.94
41_V44_T0.5930.94
87_E91_E0.5860.93
94_G98_N0.5860.93
71_V99_I0.5850.93
84_L91_E0.5820.93
32_L47_L0.5790.93
59_I111_L0.5750.93
14_T17_E0.5590.92
102_R105_E0.5590.92
24_I53_N0.5590.92
22_R60_D0.5590.92
36_K43_Y0.5590.92
101_N110_E0.5580.92
24_I60_D0.5560.91
75_A80_V0.5520.91
40_P48_L0.5430.90
74_M106_I0.5420.90
107_V111_L0.5390.90
74_M77_A0.5360.90
71_V103_A0.5330.90
3_T9_Y0.5280.89
97_N100_R0.5270.89
11_P16_P0.5270.89
93_V96_M0.5210.89
70_L103_A0.5150.88
90_M94_G0.5130.88
5_V16_P0.5120.88
31_R42_L0.5120.88
95_R102_R0.5050.87
34_Y39_R0.5040.87
94_G97_N0.5000.86
1_T16_P0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cr2Z 1 0.9554 11.6 0.903 Contact Map
2aplA 1 0.625 11.1 0.904 Contact Map
2rawB 1 0.3929 5.9 0.915 Contact Map
2qfaB 1 0.5268 5.5 0.916 Contact Map
1urjA 1 0.7054 3.2 0.925 Contact Map
4um2A 1 0.4911 3.2 0.925 Contact Map
3j21O 1 0.6071 3 0.926 Contact Map
4rndA 2 0.9018 2.5 0.929 Contact Map
2lseA 1 0.6518 1.8 0.934 Contact Map
2hy6A 3 0.1518 1.6 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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