GREMLIN Database
DUF4315 - Domain of unknown function (DUF4315)
PFAM: PF14193 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 79 (73)
Sequences: 1273 (937)
Seq/√Len: 109.7
META: 0.908

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_K27_E4.4831.00
12_T23_L3.3951.00
6_R30_K3.0341.00
39_V43_R2.6641.00
9_I23_L2.5891.00
9_I27_E2.4681.00
38_I42_V2.4551.00
5_I30_K2.2201.00
16_I20_Q2.0431.00
31_T35_N1.9611.00
5_I26_L1.8971.00
9_I30_K1.8671.00
5_I33_L1.7401.00
12_T16_I1.4061.00
67_P70_A1.3811.00
16_I19_L1.3751.00
35_N43_R1.2720.99
54_A57_K1.2640.99
16_I23_L1.2520.99
9_I26_L1.2200.99
29_Q32_E1.2180.99
12_T19_L1.1960.99
66_A70_A1.1880.99
67_P72_E1.1450.99
35_N38_I1.1380.98
34_E43_R1.0860.98
17_A20_Q1.0830.98
55_L59_L1.0740.98
23_L30_K1.0430.97
3_E7_A1.0410.97
51_E54_A1.0340.97
45_M49_P1.0270.97
51_E60_K1.0190.97
14_A18_E1.0060.97
66_A71_K0.9590.96
33_L37_E0.9510.95
69_A72_E0.9490.95
6_R10_E0.9440.95
41_L52_L0.9420.95
19_L23_L0.9390.95
21_A25_E0.9390.95
32_E36_L0.9180.94
65_P68_T0.9140.94
68_T71_K0.8870.93
15_K19_L0.8600.92
35_N39_V0.8580.92
10_E14_A0.8510.92
25_E28_R0.8510.92
11_K24_R0.8370.91
47_L50_E0.8220.90
66_A69_A0.8150.90
39_V45_M0.8000.89
44_S47_L0.7900.89
17_A21_A0.7680.87
38_I41_L0.7630.87
67_P71_K0.7620.87
5_I9_I0.7550.86
2_I53_A0.7550.86
15_K18_E0.7500.86
48_T51_E0.7470.86
3_E56_L0.7460.86
19_L22_R0.7220.84
45_M56_L0.7100.83
26_L29_Q0.7070.82
20_Q39_V0.7070.82
40_A53_A0.7030.82
26_L30_K0.7020.82
9_I13_K0.6910.81
68_T72_E0.6770.80
24_R27_E0.6720.79
8_E15_K0.6690.79
32_E35_N0.6690.79
48_T59_L0.6670.79
13_K23_L0.6570.78
66_A72_E0.6510.77
37_E40_A0.6480.77
10_E13_K0.6470.76
8_E12_T0.6460.76
4_K31_T0.6440.76
57_K60_K0.6410.76
40_A46_N0.6360.75
46_N56_L0.6360.75
34_E39_V0.6250.74
13_K24_R0.6250.74
14_A57_K0.6240.74
7_A14_A0.6230.74
2_I33_L0.6130.73
42_V52_L0.6090.72
67_P73_Q0.6060.72
54_A73_Q0.5940.70
64_P69_A0.5880.69
59_L62_G0.5870.69
70_A73_Q0.5750.68
22_R52_L0.5740.68
49_P56_L0.5740.68
10_E27_E0.5690.67
42_V56_L0.5510.64
58_A63_A0.5460.64
9_I33_L0.5420.63
22_R40_A0.5380.63
24_R28_R0.5370.63
63_A69_A0.5330.62
45_M59_L0.5210.60
36_L40_A0.5200.60
64_P68_T0.5190.60
41_L51_E0.5180.60
65_P71_K0.5150.59
9_I16_I0.5120.59
63_A70_A0.5040.58
28_R32_E0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4y66A 1 0.9747 31 0.818 Contact Map
3nr7A 2 0.6456 24.7 0.827 Contact Map
2akfA 3 0.4051 23.2 0.829 Contact Map
3u59A 2 0.9873 22.9 0.829 Contact Map
2yy0A 6 0.4304 22.5 0.83 Contact Map
4y66B 1 0.9747 21.8 0.831 Contact Map
3u1cA 2 0.9873 20.9 0.832 Contact Map
3hnwA 2 0.5063 18.3 0.837 Contact Map
4q4gX 1 0 18 0.837 Contact Map
3ghgA 2 0.8101 17.7 0.838 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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