GREMLIN Database
DUF4314 - Domain of unknown function (DUF4314)
PFAM: PF14192 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (87)
Sequences: 696 (441)
Seq/√Len: 47.3
META: 0.882

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_M11_Y3.2721.00
42_G57_A3.1241.00
10_Y42_G2.3151.00
93_E102_Y2.2861.00
57_A81_A2.0971.00
45_F58_E2.0130.99
77_I81_A1.9740.99
7_L10_Y1.9230.99
65_L69_E1.9070.99
96_V100_E1.8250.99
88_G92_R1.7780.99
8_M19_V1.6800.98
14_D17_D1.6590.98
84_G87_E1.6320.98
93_E100_E1.5590.97
90_E94_I1.5400.97
44_R81_A1.4940.96
11_Y19_V1.4790.96
42_G76_Y1.4510.95
5_R20_N1.4120.94
70_L74_K1.3700.93
17_D23_V1.3660.93
24_Y60_I1.3390.93
6_G56_V1.3220.92
15_E18_G1.3180.92
48_Y52_F1.3010.91
89_F92_R1.2810.91
78_F82_S1.2690.90
82_S87_E1.2530.90
90_E93_E1.1920.87
11_Y17_D1.1680.86
44_R57_A1.1630.86
84_G88_G1.1550.86
42_G77_I1.1550.86
49_R54_W1.1370.85
100_E104_S1.1200.84
16_D19_V1.0960.82
75_E78_F1.0940.82
83_D91_Q1.0920.82
22_K69_E1.0820.82
46_V104_S1.0820.82
85_W89_F1.0790.81
43_I60_I1.0750.81
65_L84_G1.0330.79
99_G103_V1.0270.78
58_E94_I1.0260.78
69_E87_E1.0200.78
18_G22_K1.0160.77
45_F57_A1.0140.77
19_V23_V1.0130.77
45_F60_I1.0120.77
87_E90_E0.9850.75
64_E70_L0.9770.75
96_V99_G0.9740.74
9_H42_G0.9650.74
59_C73_L0.9580.73
51_G55_G0.9300.71
7_L42_G0.9270.71
79_G91_Q0.9130.69
48_Y54_W0.9130.69
5_R56_V0.8950.68
21_E78_F0.8900.67
79_G82_S0.8860.67
71_E74_K0.8790.66
24_Y78_F0.8630.65
8_M23_V0.8620.65
47_E51_G0.8350.62
83_D87_E0.8220.61
95_K100_E0.8070.60
45_F48_Y0.8050.60
14_D19_V0.8050.60
44_R105_F0.8030.59
8_M22_K0.8010.59
96_V101_L0.7980.59
8_M42_G0.7840.58
20_N23_V0.7610.55
50_E72_L0.7560.55
41_S73_L0.7460.54
93_E104_S0.7380.53
44_R58_E0.7380.53
14_D21_E0.7350.53
15_E19_V0.7350.53
14_D20_N0.7340.53
6_G10_Y0.7300.52
58_E100_E0.7270.52
54_W105_F0.7270.52
61_V71_E0.7220.51
59_C81_A0.7210.51
44_R85_W0.7200.51
65_L70_L0.6970.49
12_D52_F0.6950.49
69_E84_G0.6840.48
24_Y44_R0.6830.48
18_G23_V0.6790.47
95_K106_W0.6760.47
66_T97_D0.6720.46
16_D98_D0.6640.46
64_E69_E0.6480.44
55_G58_E0.6460.44
19_V22_K0.6350.43
80_Q84_G0.6350.43
58_E61_V0.6310.42
8_M61_V0.6280.42
82_S94_I0.6260.42
46_V76_Y0.6220.42
69_E89_F0.6150.41
57_A77_I0.6100.40
58_E92_R0.6060.40
48_Y76_Y0.6050.40
67_G101_L0.5980.39
15_E21_E0.5970.39
76_Y81_A0.5850.38
56_V74_K0.5830.38
50_E54_W0.5770.37
48_Y95_K0.5750.37
85_W88_G0.5700.37
67_G99_G0.5640.36
66_T69_E0.5640.36
11_Y72_L0.5620.36
81_A85_W0.5620.36
52_F60_I0.5590.36
17_D20_N0.5430.34
48_Y58_E0.5370.34
84_G90_E0.5340.33
46_V101_L0.5270.33
7_L55_G0.5190.32
61_V101_L0.5160.32
45_F105_F0.5080.31
61_V89_F0.5040.31
6_G9_H0.5000.30
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j8eG 3 0.4811 3.6 0.933 Contact Map
4c5eE 2 0.2358 3.2 0.935 Contact Map
1sa3A 1 0.4811 2.1 0.941 Contact Map
2l7kA 1 0.6792 2.1 0.941 Contact Map
4c5hB 1 0.1981 2 0.941 Contact Map
4c5iC 1 0.1226 1.8 0.943 Contact Map
4xypA 3 0.5283 1.8 0.943 Contact Map
4epuA 2 0.5 1.7 0.944 Contact Map
4mgqA 1 0.4906 1.6 0.945 Contact Map
3shgA 1 0.8302 1.6 0.945 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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