GREMLIN Database
YodL - YodL-like
PFAM: PF14191 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (99)
Sequences: 2089 (1572)
Seq/√Len: 158.0
META: 0.929

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_E24_E3.3521.00
56_E60_I2.6891.00
78_V87_A2.6621.00
80_K85_V2.5321.00
66_F69_H2.3991.00
8_K38_E2.2611.00
3_A39_L2.2231.00
54_I71_L2.0911.00
39_L42_T2.0081.00
71_L77_V1.9531.00
86_T97_E1.9341.00
24_E28_A1.8521.00
3_A85_V1.7471.00
17_Y36_N1.6921.00
59_N70_S1.6791.00
22_L96_K1.6681.00
90_V95_F1.6261.00
21_S24_E1.6181.00
10_D13_E1.5641.00
56_E61_D1.5521.00
7_L14_T1.5401.00
53_D56_E1.5381.00
18_R69_H1.4741.00
55_Y59_N1.4561.00
17_Y30_L1.4321.00
4_I58_F1.4271.00
57_K61_D1.4001.00
25_L89_Y1.3971.00
49_E53_D1.3941.00
51_L88_Y1.3311.00
73_V92_S1.3161.00
41_Y65_D1.2971.00
2_F43_G1.2891.00
3_A42_T1.2711.00
58_F66_F1.2571.00
2_F54_I1.2411.00
41_Y63_P1.2371.00
3_A78_V1.2341.00
74_S89_Y1.1911.00
51_L79_L1.1911.00
81_Q84_E1.1751.00
22_L26_E1.1581.00
20_E28_A1.1461.00
33_D36_N1.1401.00
2_F45_L1.1331.00
50_T53_D1.1321.00
25_L32_V1.1161.00
3_A80_K1.0920.99
45_L50_T1.0860.99
4_I77_V1.0800.99
88_Y97_E1.0790.99
22_L32_V1.0730.99
4_I71_L1.0500.99
19_F72_S1.0060.99
53_D57_K1.0060.99
2_F57_K1.0040.99
41_Y58_F0.9880.99
7_L36_N0.9830.99
9_D18_R0.9670.99
17_Y25_L0.9320.98
54_I79_L0.9310.98
78_V85_V0.9310.98
62_H66_F0.9290.98
19_F74_S0.9070.98
93_F96_K0.9030.98
59_N72_S0.8910.98
46_D49_E0.8840.98
55_Y70_S0.8830.98
32_V36_N0.8820.98
58_F68_G0.8790.98
52_E77_V0.8790.98
52_E56_E0.8740.97
52_E90_V0.8710.97
21_S27_K0.8710.97
34_R39_L0.8570.97
59_N62_H0.8340.97
8_K12_D0.8320.97
45_L57_K0.8160.96
23_D26_E0.8060.96
40_V68_G0.8040.96
63_P66_F0.8020.96
45_L48_G0.8000.96
20_E25_L0.7970.96
5_Y39_L0.7940.96
47_D50_T0.7760.95
48_G52_E0.7660.95
50_T54_I0.7580.94
97_E100_E0.7580.94
65_D68_G0.7560.94
7_L16_D0.7420.94
9_D14_T0.7150.92
51_L77_V0.7100.92
6_Q72_S0.7100.92
14_T17_Y0.7080.92
43_G54_I0.6800.90
43_G57_K0.6800.90
3_A34_R0.6700.90
46_D50_T0.6450.88
10_D14_T0.6440.88
49_E61_D0.6360.87
52_E93_F0.6310.87
22_L95_F0.6260.86
28_A98_L0.6240.86
13_E36_N0.6240.86
14_T20_E0.6210.86
7_L10_D0.6180.86
6_Q68_G0.6180.86
22_L25_L0.6110.85
69_H72_S0.5990.84
17_Y32_V0.5950.83
21_S91_D0.5860.83
37_Y74_S0.5840.82
14_T36_N0.5810.82
24_E27_K0.5790.82
47_D81_Q0.5720.81
7_L69_H0.5720.81
17_Y29_G0.5710.81
40_V69_H0.5660.80
72_S93_F0.5660.80
5_Y17_Y0.5590.79
23_D28_A0.5520.79
52_E95_F0.5510.79
76_V98_L0.5510.79
49_E99_P0.5480.78
4_I66_F0.5420.77
5_Y34_R0.5400.77
55_Y62_H0.5370.77
23_D27_K0.5370.77
45_L81_Q0.5360.77
19_F69_H0.5330.76
58_F74_S0.5320.76
64_A67_K0.5320.76
21_S89_Y0.5290.76
79_L86_T0.5290.76
74_S91_D0.5270.75
82_D85_V0.5250.75
62_H70_S0.5240.75
42_T81_Q0.5180.74
7_L18_R0.5180.74
4_I62_H0.5160.74
7_L15_R0.5150.74
70_S90_V0.5140.74
21_S28_A0.5110.73
49_E57_K0.5090.73
4_I40_V0.5030.72
17_Y20_E0.5000.72
7_L13_E0.5000.72
12_D28_A0.5000.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nazA 2 0.3465 6.5 0.917 Contact Map
1nnvA 1 0.7327 5.7 0.919 Contact Map
1v1cA 1 0.5149 5.5 0.92 Contact Map
4z04A 2 0.3168 5.5 0.92 Contact Map
3r4qA 2 0.3465 4.8 0.922 Contact Map
3g12A 2 0.3168 4.6 0.923 Contact Map
1u7iA 2 0.3366 4.5 0.924 Contact Map
2bjqA 1 0.7426 4.4 0.924 Contact Map
3uj4A 1 0.3168 4.1 0.925 Contact Map
2qntA 2 0.3762 3.9 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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