GREMLIN Database
YaaC - YaaC-like Protein
PFAM: PF14175 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 319 (303)
Sequences: 791 (732)
Seq/√Len: 42.0
META: 0.645

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
142_L267_I7.4461.00
52_A64_L4.0531.00
44_Q61_P3.6781.00
46_R50_E3.6201.00
44_Q62_L3.4281.00
106_F109_D3.3921.00
142_L271_L3.0571.00
273_Y277_M2.8861.00
72_A122_L2.7841.00
62_L279_A2.6551.00
272_M312_F2.6231.00
94_V270_L2.5661.00
304_F308_S2.5091.00
4_T10_Y2.5081.00
45_A71_L2.5061.00
49_Y68_F2.4261.00
65_Y69_L2.3991.00
140_K159_K2.2261.00
65_Y303_E2.1641.00
13_L17_R2.1180.99
272_M304_F2.0830.99
53_E310_R2.0150.99
264_E311_Q1.9960.99
4_T11_V1.9910.99
49_Y304_F1.9780.99
48_F299_W1.9720.99
121_E124_E1.9420.99
192_T196_F1.9370.99
43_E47_E1.9290.99
153_Y300_L1.9200.99
191_M195_R1.8620.98
124_E130_K1.8510.98
285_W289_L1.8290.98
6_D46_R1.8250.98
65_Y70_N1.7810.98
67_G286_W1.7800.98
67_G313_P1.7690.98
65_Y283_P1.7440.98
50_E54_N1.7430.98
8_W36_Y1.7420.98
13_L16_K1.7330.98
55_A59_S1.7220.97
11_V17_R1.7160.97
303_E311_Q1.6920.97
143_L304_F1.6800.97
311_Q314_Y1.6580.97
100_K109_D1.6510.97
7_S317_A1.6450.97
65_Y276_S1.6300.96
310_R314_Y1.6120.96
126_L265_L1.5930.96
151_R163_F1.5910.96
9_E21_K1.5910.96
69_L118_L1.5760.96
4_T8_W1.5740.96
142_L264_E1.5720.96
173_D176_T1.5690.96
94_V119_F1.5590.95
150_H311_Q1.5490.95
128_H131_P1.5480.95
60_K309_P1.5470.95
56_P59_S1.5430.95
65_Y268_H1.5310.95
47_E59_S1.5240.95
45_A49_Y1.5200.95
49_Y269_Y1.5150.95
65_Y285_W1.5100.95
50_E53_E1.5040.94
105_S109_D1.4980.94
68_F272_M1.4930.94
71_L273_Y1.4780.94
4_T13_L1.4740.94
152_A303_E1.4490.93
43_E56_P1.4340.93
8_W11_V1.4270.93
68_F309_P1.4030.92
143_L267_I1.3980.92
8_W14_W1.3780.91
250_L254_L1.3770.91
73_K117_G1.3750.91
55_A63_L1.3660.91
70_N293_L1.3610.91
150_H163_F1.3560.91
195_R199_Y1.3550.91
145_N298_Y1.3530.91
13_L23_A1.3520.90
122_L312_F1.3480.90
193_P196_F1.3470.90
263_P266_L1.3470.90
4_T9_E1.3470.90
226_L238_R1.3410.90
251_Y254_L1.3270.90
119_F266_L1.3210.89
303_E314_Y1.3210.89
139_L271_L1.3200.89
10_Y13_L1.3170.89
75_L316_I1.3140.89
275_L301_I1.3060.89
71_L276_S1.2980.89
148_E268_H1.2860.88
63_L67_G1.2860.88
276_S308_S1.2720.88
117_G196_F1.2470.87
52_A63_L1.2390.86
106_F110_E1.2340.86
68_F307_I1.2280.86
151_R161_E1.2240.85
148_E311_Q1.2220.85
193_P197_L1.2180.85
310_R317_A1.2170.85
9_E16_K1.2140.85
95_S112_K1.2060.85
66_Y93_G1.2010.84
93_G280_R1.1970.84
51_A56_P1.1890.84
45_A304_F1.1860.84
44_Q139_L1.1680.83
5_F8_W1.1650.82
77_L273_Y1.1600.82
127_F130_K1.1320.81
77_L282_E1.1260.80
277_M286_W1.1240.80
90_L139_L1.1210.80
225_L228_N1.1170.80
10_Y18_C1.1140.80
66_Y92_H1.1090.79
92_H280_R1.1080.79
93_G281_Y1.1010.79
279_A287_G1.1000.79
12_Q19_Y1.0980.79
242_L278_I1.0930.78
141_D306_S1.0930.78
165_P269_Y1.0900.78
48_F59_S1.0790.77
192_T197_L1.0770.77
59_S299_W1.0670.77
251_Y260_L1.0650.76
44_Q75_L1.0620.76
150_H303_E1.0590.76
44_Q51_A1.0560.76
191_M200_L1.0540.76
84_P282_E1.0350.74
274_N277_M1.0220.73
70_N286_W1.0170.73
92_H281_Y1.0080.72
80_D121_E1.0070.72
195_R198_E1.0070.72
55_A276_S1.0070.72
107_L117_G0.9960.71
10_Y16_K0.9910.71
200_L203_D0.9870.71
139_L274_N0.9830.70
66_Y280_R0.9790.70
295_S302_S0.9740.70
74_A269_Y0.9730.70
11_V16_K0.9720.70
194_E199_Y0.9710.69
11_V14_W0.9700.69
12_Q17_R0.9670.69
230_L234_H0.9600.69
61_P75_L0.9590.68
146_I261_R0.9580.68
150_H251_Y0.9490.68
73_K311_Q0.9460.67
272_M299_W0.9450.67
242_L245_N0.9390.67
290_L294_D0.9370.67
253_P279_A0.9360.67
309_P313_P0.9360.67
75_L94_V0.9320.66
45_A128_H0.9290.66
64_L146_I0.9260.66
45_A192_T0.9240.66
44_Q278_I0.9240.66
15_L19_Y0.9220.65
303_E312_F0.9170.65
61_P275_L0.9130.65
65_Y277_M0.9130.65
280_R283_P0.9090.64
43_E58_S0.9090.64
145_N314_Y0.9080.64
196_F200_L0.9050.64
67_G70_N0.9050.64
55_A244_I0.9030.64
64_L139_L0.8990.63
47_E56_P0.8980.63
193_P200_L0.8940.63
214_T217_N0.8930.63
211_F216_E0.8930.63
17_R22_L0.8920.63
57_L278_I0.8870.62
181_F247_Y0.8850.62
11_V62_L0.8830.62
153_Y159_K0.8810.62
59_S62_L0.8810.62
64_L68_F0.8810.62
274_N282_E0.8790.62
66_Y281_Y0.8790.62
104_Y114_Q0.8780.62
272_M305_L0.8770.61
91_A114_Q0.8740.61
196_F232_E0.8730.61
9_E14_W0.8720.61
70_N283_P0.8680.61
8_W12_Q0.8670.61
191_M196_F0.8580.60
23_A38_F0.8550.59
11_V39_L0.8550.59
166_L183_A0.8510.59
60_K306_S0.8410.58
7_S11_V0.8380.58
262_L301_I0.8320.57
6_D39_L0.8250.57
12_Q39_L0.8250.57
182_P282_E0.8200.56
6_D19_Y0.8200.56
13_L21_K0.8190.56
14_W18_C0.8190.56
236_L262_L0.8170.56
94_V113_I0.8140.56
73_K274_N0.8120.56
44_Q49_Y0.8050.55
14_W23_A0.8050.55
206_R213_W0.8040.55
296_K309_P0.8040.55
67_G235_P0.8030.55
9_E12_Q0.8020.55
111_V168_I0.8010.55
145_N150_H0.8010.55
14_W22_L0.7990.54
94_V289_L0.7980.54
250_L253_P0.7950.54
164_I205_I0.7940.54
4_T7_S0.7940.54
67_G109_D0.7870.53
14_W17_R0.7870.53
303_E309_P0.7850.53
143_L307_I0.7840.53
303_E307_I0.7820.53
65_Y311_Q0.7810.53
99_R195_R0.7770.52
150_H161_E0.7730.52
194_E202_K0.7710.52
286_W313_P0.7700.52
194_E198_E0.7700.52
73_K269_Y0.7700.52
73_K309_P0.7690.52
70_N303_E0.7690.52
72_A118_L0.7660.51
226_L229_L0.7640.51
109_D118_L0.7620.51
13_L20_K0.7610.51
101_K109_D0.7550.50
72_A84_P0.7530.50
137_Y152_A0.7500.50
115_K134_G0.7480.50
11_V15_L0.7470.49
107_L110_E0.7470.49
20_K23_A0.7440.49
69_L73_K0.7430.49
68_F304_F0.7410.49
14_W95_S0.7410.49
69_L277_M0.7400.49
75_L79_K0.7350.48
166_L218_I0.7330.48
152_A299_W0.7330.48
10_Y15_L0.7300.48
170_R227_L0.7300.48
49_Y67_G0.7280.48
274_N283_P0.7230.47
69_L286_W0.7220.47
44_Q274_N0.7180.47
166_L246_G0.7170.47
112_K135_E0.7160.47
80_D115_K0.7140.46
48_F303_E0.7110.46
299_W314_Y0.7110.46
114_Q117_G0.7100.46
297_D300_L0.7060.46
117_G301_I0.7030.45
58_S64_L0.7010.45
291_K313_P0.6990.45
70_N312_F0.6990.45
41_Y305_L0.6950.45
181_F205_I0.6950.45
151_R303_E0.6930.44
6_D11_V0.6900.44
77_L84_P0.6850.44
111_V196_F0.6850.44
76_L308_S0.6840.44
69_L152_A0.6840.44
264_E268_H0.6840.44
178_E198_E0.6830.43
95_S114_Q0.6820.43
4_T16_K0.6810.43
154_L300_L0.6760.43
198_E202_K0.6750.43
48_F63_L0.6730.43
65_Y273_Y0.6720.42
114_Q120_P0.6720.42
60_K87_T0.6710.42
84_P100_K0.6710.42
37_R41_Y0.6680.42
49_Y56_P0.6670.42
233_L240_P0.6650.42
144_S252_L0.6620.42
300_L304_F0.6600.41
47_E58_S0.6590.41
64_L309_P0.6590.41
5_F19_Y0.6550.41
184_E276_S0.6550.41
8_W48_F0.6520.41
239_K258_K0.6500.40
106_F114_Q0.6480.40
274_N286_W0.6470.40
68_F73_K0.6440.40
227_L230_L0.6430.40
289_L299_W0.6380.39
138_S141_D0.6380.39
104_Y110_E0.6380.39
51_A263_P0.6350.39
49_Y185_I0.6320.39
45_A186_L0.6310.39
279_A291_K0.6300.39
62_L312_F0.6290.39
106_F301_I0.6290.39
83_Y97_R0.6280.38
13_L22_L0.6270.38
145_N163_F0.6260.38
77_L83_Y0.6210.38
65_Y286_W0.6210.38
286_W311_Q0.6200.38
185_I188_D0.6200.38
61_P90_L0.6160.37
44_Q70_N0.6150.37
148_E313_P0.6150.37
206_R209_K0.6150.37
138_S152_A0.6140.37
16_K21_K0.6090.37
63_L273_Y0.6070.37
83_Y118_L0.6050.36
10_Y22_L0.6020.36
254_L266_L0.6020.36
314_Y317_A0.6010.36
148_E308_S0.5980.36
84_P104_Y0.5980.36
8_W70_N0.5970.36
49_Y268_H0.5960.36
73_K90_L0.5960.36
192_T198_E0.5960.36
8_W51_A0.5950.36
185_I250_L0.5940.36
283_P304_F0.5930.35
70_N287_G0.5930.35
117_G286_W0.5920.35
73_K277_M0.5880.35
153_Y156_Y0.5880.35
43_E123_S0.5860.35
12_Q253_P0.5850.35
56_P243_Y0.5840.35
60_K83_Y0.5830.35
282_E305_L0.5820.34
89_V272_M0.5820.34
156_Y315_L0.5820.34
77_L148_E0.5810.34
232_E265_L0.5810.34
69_L273_Y0.5770.34
269_Y277_M0.5770.34
205_I223_E0.5760.34
61_P286_W0.5760.34
262_L295_S0.5740.34
149_I164_I0.5700.33
262_L315_L0.5690.33
80_D85_E0.5690.33
90_L118_L0.5680.33
52_A288_E0.5680.33
74_A148_E0.5670.33
145_N299_W0.5660.33
16_K23_A0.5660.33
77_L90_L0.5650.33
58_S279_A0.5640.33
100_K117_G0.5630.33
118_L272_M0.5620.33
196_F222_E0.5620.33
145_N279_A0.5610.33
18_C21_K0.5610.33
6_D10_Y0.5590.33
167_E231_K0.5570.32
14_W298_Y0.5560.32
41_Y85_E0.5550.32
67_G277_M0.5540.32
178_E212_K0.5540.32
213_W236_L0.5530.32
303_E313_P0.5530.32
272_M308_S0.5530.32
62_L119_F0.5510.32
48_F131_P0.5500.32
211_F300_L0.5500.32
54_N257_D0.5490.32
108_E210_R0.5490.32
192_T195_R0.5480.32
70_N292_H0.5470.32
21_K231_K0.5440.31
16_K22_L0.5430.31
226_L276_S0.5420.31
244_I300_L0.5410.31
146_I307_I0.5400.31
165_P300_L0.5370.31
18_C124_E0.5370.31
252_L276_S0.5360.31
38_F81_P0.5350.31
21_K217_N0.5340.31
38_F41_Y0.5340.31
112_K130_K0.5330.30
55_A315_L0.5330.30
20_K214_T0.5330.30
149_I300_L0.5330.30
110_E117_G0.5300.30
69_L312_F0.5300.30
220_T231_K0.5300.30
149_I304_F0.5290.30
43_E46_R0.5260.30
160_K248_G0.5260.30
147_P308_S0.5250.30
10_Y14_W0.5240.30
11_V246_G0.5240.30
112_K136_K0.5240.30
64_L152_A0.5230.30
139_L301_I0.5230.30
63_L290_L0.5190.29
164_I184_E0.5190.29
16_K20_K0.5190.29
12_Q16_K0.5180.29
6_D22_L0.5160.29
311_Q315_L0.5160.29
238_R243_Y0.5160.29
76_L118_L0.5140.29
149_I260_L0.5140.29
108_E212_K0.5120.29
64_L113_I0.5120.29
45_A48_F0.5120.29
197_L215_E0.5090.29
273_Y276_S0.5070.28
98_K112_K0.5060.28
104_Y109_D0.5060.28
305_L312_F0.5060.28
237_L242_L0.5050.28
57_L146_I0.5040.28
119_F123_S0.5040.28
97_R282_E0.5040.28
71_L313_P0.5030.28
116_N190_H0.5020.28
90_L96_T0.5010.28
289_L304_F0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hsbA 2 0.373 8.2 0.963 Contact Map
1ufbA 3 0.3636 5.4 0.966 Contact Map
1wolA 1 0.3699 4.6 0.967 Contact Map
4lrvA 5 0.1442 3.6 0.969 Contact Map
4nqfA 2 0.4389 3.5 0.969 Contact Map
2h7bA 1 0.163 3.2 0.969 Contact Map
1bajA 2 0.1129 3.1 0.97 Contact Map
3o10A 2 0.4075 2.7 0.97 Contact Map
1o3uA 2 0.3574 2.3 0.972 Contact Map
2ld7B 1 0.2351 1.9 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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