GREMLIN Database
SieB - Superinfection exclusion protein B
PFAM: PF14163 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 151 (145)
Sequences: 778 (713)
Seq/√Len: 59.2
META: 0.76

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_G40_F4.9921.00
11_L15_L4.5921.00
24_G33_R4.0211.00
100_L107_V3.4421.00
86_I100_L3.0171.00
137_I141_A2.7861.00
8_A41_L2.6501.00
144_Y148_H2.4501.00
137_I142_W2.3431.00
75_R113_K2.2571.00
6_A44_L2.1361.00
94_N146_N2.1071.00
6_A10_G2.0821.00
127_G132_G2.0731.00
106_V109_G1.9881.00
69_K73_K1.9631.00
23_L37_G1.8821.00
72_I140_W1.8731.00
111_V118_R1.8461.00
21_E26_D1.7090.99
100_L116_I1.6880.99
133_F137_I1.6720.99
109_G113_K1.6670.99
96_R142_W1.6380.99
87_L91_I1.6360.99
9_S40_F1.5590.98
34_P38_L1.5530.98
86_I106_V1.4800.98
140_W144_Y1.4430.97
33_R37_G1.4160.97
87_L90_F1.4010.97
118_R122_V1.3940.97
117_Y136_N1.3930.97
141_A145_L1.3770.97
51_L54_W1.3650.96
90_F98_L1.3570.96
89_E93_Q1.3550.96
14_F40_F1.3520.96
27_E30_E1.3250.96
83_E109_G1.3210.96
119_A122_V1.3170.96
142_W146_N1.3100.95
12_L29_R1.3060.95
83_E113_K1.2880.95
138_Q141_A1.2790.95
5_L39_V1.2690.95
15_L19_L1.2680.95
116_I145_L1.2580.94
108_A112_A1.2340.94
20_L29_R1.1900.92
105_G136_N1.1850.92
20_L25_L1.1850.92
135_Y141_A1.1580.91
128_G131_L1.1530.91
89_E98_L1.1510.91
10_G14_F1.1440.91
75_R96_R1.1330.90
105_G120_S1.1280.90
134_P142_W1.1230.90
55_I70_K1.1160.90
96_R113_K1.1000.89
63_I70_K1.0810.88
25_L37_G1.0760.88
51_L55_I1.0720.88
66_K70_K1.0580.87
79_L87_L1.0570.87
4_A49_V1.0460.87
133_F141_A1.0420.86
9_S43_S1.0410.86
137_I145_L1.0390.86
103_D109_G1.0340.86
90_F107_V1.0330.86
129_A132_G1.0130.85
80_T105_G1.0030.84
86_I107_V0.9940.84
115_I141_A0.9790.83
91_I94_N0.9670.82
17_D29_R0.9590.81
27_E31_E0.9590.81
97_T119_A0.9570.81
97_T105_G0.9490.81
8_A45_S0.9420.80
135_Y138_Q0.9300.79
4_A8_A0.9250.79
108_A111_V0.9210.79
127_G134_P0.9120.78
12_L88_R0.9060.78
133_F138_Q0.9050.77
88_R92_I0.8960.77
105_G117_Y0.8890.76
26_D30_E0.8870.76
63_I67_K0.8850.76
102_I120_S0.8670.74
111_V135_Y0.8650.74
106_V116_I0.8570.74
4_A46_L0.8470.73
80_T96_R0.8470.73
83_E96_R0.8330.71
85_A101_P0.8270.71
22_K49_V0.8270.71
98_L107_V0.8250.71
83_E134_P0.8150.70
139_P145_L0.8110.69
11_L16_P0.7990.68
14_F37_G0.7960.68
109_G136_N0.7930.68
83_E106_V0.7910.67
20_L26_D0.7820.67
28_F32_Y0.7770.66
60_K73_K0.7750.66
88_R104_D0.7730.66
37_G41_L0.7710.65
139_P142_W0.7670.65
97_T109_G0.7640.65
76_L140_W0.7570.64
13_L36_I0.7530.64
134_P137_I0.7520.64
24_G119_A0.7510.63
135_Y140_W0.7480.63
74_K112_A0.7480.63
143_E147_K0.7420.62
96_R109_G0.7400.62
92_I101_P0.7370.62
8_A14_F0.7310.61
109_G117_Y0.7300.61
42_L68_L0.7230.60
51_L63_I0.7180.60
29_R36_I0.7160.60
136_N145_L0.7110.59
89_E101_P0.7100.59
45_S48_L0.7070.59
5_L16_P0.7050.59
60_K64_R0.7050.59
100_L113_K0.7030.58
86_I116_I0.6960.58
29_R33_R0.6900.57
86_I103_D0.6870.57
13_L32_Y0.6860.56
135_Y139_P0.6730.55
133_F136_N0.6690.55
143_E146_N0.6690.55
8_A28_F0.6570.53
90_F101_P0.6560.53
35_W96_R0.6490.52
27_E44_L0.6450.52
40_F80_T0.6380.51
65_K68_L0.6340.51
32_Y36_I0.6320.50
65_K114_G0.6260.50
130_G141_A0.6240.50
27_E73_K0.6230.49
128_G134_P0.6190.49
113_K142_W0.6160.49
66_K147_K0.6160.49
98_L116_I0.6120.48
73_K144_Y0.6120.48
95_T142_W0.6110.48
42_L48_L0.6100.48
90_F115_I0.6090.48
10_G57_K0.6070.48
3_L17_D0.6000.47
20_L78_S0.6000.47
11_L74_K0.5980.47
11_L22_K0.5980.47
88_R107_V0.5930.46
14_F86_I0.5910.46
17_D39_V0.5880.46
77_K144_Y0.5870.45
4_A45_S0.5840.45
80_T97_T0.5830.45
137_I140_W0.5830.45
90_F95_T0.5790.45
131_L141_A0.5780.44
115_I134_P0.5750.44
36_I42_L0.5740.44
79_L84_K0.5710.44
103_D106_V0.5700.44
12_L19_L0.5680.43
76_L79_L0.5660.43
89_E92_I0.5660.43
131_L134_P0.5630.43
28_F36_I0.5620.43
23_L41_L0.5610.43
3_L47_L0.5580.42
41_L143_E0.5550.42
74_K78_S0.5550.42
4_A10_G0.5510.42
31_E34_P0.5460.41
84_K87_L0.5410.40
95_T98_L0.5380.40
9_S39_V0.5370.40
128_G132_G0.5360.40
67_K74_K0.5340.40
58_W68_L0.5320.39
29_R76_L0.5320.39
133_F142_W0.5320.39
92_I95_T0.5310.39
3_L8_A0.5280.39
48_L67_K0.5260.39
80_T106_V0.5240.39
95_T107_V0.5240.39
8_A13_L0.5230.39
120_S134_P0.5210.38
80_T117_Y0.5190.38
15_L32_Y0.5160.38
85_A102_I0.5150.38
57_K61_R0.5130.37
90_F116_I0.5110.37
95_T104_D0.5100.37
88_R98_L0.5090.37
28_F34_P0.5060.37
41_L70_K0.5060.37
15_L59_I0.5060.37
48_L79_L0.5050.37
130_G133_F0.5040.37
18_S27_E0.5010.36
70_K74_K0.5010.36
90_F106_V0.5000.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mnuA 2 0.6623 25.6 0.898 Contact Map
3bpvA 2 0.649 19.8 0.903 Contact Map
2a61A 2 0.6556 18.1 0.904 Contact Map
1i1gA 5 0.4768 17.9 0.905 Contact Map
2pn6A 5 0.4768 17.8 0.905 Contact Map
4asnA 2 0.4768 16.8 0.906 Contact Map
1lj9A 2 0.649 16.7 0.906 Contact Map
4l9nA 2 0.6556 16.3 0.907 Contact Map
4h33A 3 0.4305 16.1 0.907 Contact Map
2qq9A 2 0.4437 15.5 0.907 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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