GREMLIN Database
DUF4307 - Domain of unknown function (DUF4307)
PFAM: PF14155 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (109)
Sequences: 3087 (2276)
Seq/√Len: 218.0
META: 0.723

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_D47_T3.3221.00
45_D102_R2.9281.00
68_A103_A2.7101.00
70_D101_R2.7071.00
75_E78_R2.4571.00
19_W23_A2.3771.00
51_T92_R2.2611.00
47_T96_T2.1621.00
63_V80_E2.1511.00
69_L73_G2.1141.00
56_R62_A2.0921.00
52_F81_V2.0411.00
49_T96_T1.9521.00
66_V95_V1.9011.00
50_V106_G1.8691.00
38_I53_E1.8441.00
51_T94_T1.8291.00
79_R95_V1.8231.00
65_T80_E1.7361.00
42_V48_V1.6891.00
53_E92_R1.6851.00
70_D74_A1.6111.00
36_E53_E1.5771.00
56_R59_G1.5741.00
67_R75_E1.5231.00
21_A25_Y1.4971.00
79_R97_V1.4831.00
67_R107_E1.4761.00
99_T103_A1.4411.00
83_V93_V1.4151.00
71_E104_V1.3821.00
65_T78_R1.3691.00
43_V47_T1.3041.00
55_T90_T1.2651.00
39_G51_T1.2631.00
6_V10_A1.2461.00
52_F95_V1.2411.00
69_L105_T1.2331.00
41_E49_T1.2221.00
22_W26_S1.2191.00
48_V68_A1.2171.00
69_L107_E1.2091.00
14_V17_L1.2031.00
61_P84_P1.1991.00
63_V82_T1.1891.00
42_V102_R1.1671.00
48_V106_G1.1501.00
5_L9_A1.1401.00
19_W22_W1.1181.00
43_V49_T1.1071.00
97_V106_G1.0741.00
4_R7_I1.0641.00
58_D89_R1.0591.00
49_T94_T1.0581.00
56_R61_P1.0381.00
77_G97_V1.0351.00
38_I51_T1.0241.00
61_P82_T1.0201.00
7_I11_V1.0051.00
36_E55_T0.9841.00
56_R83_V0.9841.00
72_D101_R0.9771.00
15_V19_W0.9671.00
35_A52_F0.9621.00
81_V95_V0.9601.00
59_G87_D0.9300.99
52_F108_V0.9240.99
57_P60_S0.9060.99
68_A99_T0.8980.99
40_F105_T0.8890.99
2_R6_V0.8790.99
40_F104_V0.8780.99
8_V12_L0.8730.99
33_V62_A0.8650.99
5_L8_V0.8580.99
42_V103_A0.8580.99
61_P85_A0.8540.99
18_A22_W0.8540.99
20_L23_A0.8540.99
52_F93_V0.8380.99
54_V62_A0.8330.99
35_A108_V0.8230.99
30_T57_P0.8220.99
52_F83_V0.8070.99
48_V103_A0.8010.98
56_R84_P0.7960.98
81_V93_V0.7920.98
37_L40_F0.7850.98
83_V95_V0.7680.98
24_G29_S0.7520.98
5_L12_L0.7440.98
3_R7_I0.7430.98
56_R60_S0.7420.97
67_R109_Y0.7330.97
4_R8_V0.7240.97
53_E90_T0.7160.97
67_R73_G0.7150.97
32_P57_P0.7010.96
67_R78_R0.6930.96
20_L27_H0.6910.96
10_A17_L0.6890.96
16_A20_L0.6860.96
43_V96_T0.6730.96
52_F94_T0.6620.95
76_V101_R0.6600.95
10_A14_V0.6600.95
7_I10_A0.6570.95
50_V97_V0.6530.95
20_L24_G0.6500.95
9_A13_A0.6460.94
38_I92_R0.6450.94
19_W26_S0.6420.94
21_A24_G0.6370.94
62_A83_V0.6330.94
37_L105_T0.6280.94
107_E110_G0.6250.93
58_D61_P0.6200.93
11_V18_A0.6180.93
13_A17_L0.6160.93
52_F66_V0.6010.92
76_V99_T0.6010.92
70_D100_T0.5990.92
61_P83_V0.5950.92
100_T104_V0.5940.92
9_A24_G0.5920.91
6_V9_A0.5880.91
13_A16_A0.5870.91
35_A80_E0.5790.91
41_E51_T0.5710.90
3_R18_A0.5640.89
36_E90_T0.5600.89
21_A26_S0.5550.89
23_A27_H0.5530.89
56_R91_V0.5530.89
8_V16_A0.5490.88
10_A26_S0.5460.88
40_F106_G0.5440.88
65_T75_E0.5440.88
12_L19_W0.5420.88
17_L24_G0.5420.88
12_L15_V0.5420.88
25_Y29_S0.5390.87
87_D96_T0.5370.87
68_A76_V0.5360.87
8_V11_V0.5350.87
5_L16_A0.5330.87
42_V99_T0.5320.87
11_V15_V0.5310.86
30_T34_S0.5310.86
86_G91_V0.5260.86
3_R9_A0.5240.86
108_V111_C0.5220.86
18_A24_G0.5170.85
38_I106_G0.5170.85
85_A93_V0.5150.85
76_V104_V0.5130.85
57_P63_V0.5130.85
69_L74_A0.5120.84
65_T109_Y0.5070.84
50_V108_V0.5060.84
19_W27_H0.5040.84
50_V66_V0.5010.83
19_W24_G0.5010.83
69_L75_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j6da 3 0 12.6 0.897 Contact Map
4i3gA 1 0.9099 6.9 0.908 Contact Map
3aqpA 1 0.9459 6.8 0.909 Contact Map
4v3iA 2 0 4.9 0.915 Contact Map
2yiuB 1 0.2793 4.5 0.916 Contact Map
3abzA 3 0.9009 4.2 0.917 Contact Map
2x41A 1 0.8829 4 0.918 Contact Map
3lb6C 1 0 3.3 0.921 Contact Map
3s88I 1 0.2703 3.1 0.922 Contact Map
4ogqD 1 0.7297 3 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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