GREMLIN Database
YrhK - YrhK-like protein
PFAM: PF14145 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 62 (58)
Sequences: 2411 (1448)
Seq/√Len: 190.2
META: 0.778

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_S47_S4.2101.00
26_F44_L2.4931.00
19_L44_L2.1581.00
24_L35_W2.1001.00
36_W40_T1.9381.00
35_W38_A1.7191.00
44_L48_V1.6991.00
12_A51_G1.6571.00
17_C49_L1.6511.00
25_F43_F1.6161.00
7_S53_S1.5401.00
15_S50_F1.5241.00
19_L48_V1.4711.00
21_G25_F1.4691.00
12_A55_V1.4511.00
26_F41_W1.4421.00
14_G50_F1.3841.00
17_C42_L1.3741.00
18_F47_S1.2561.00
29_V34_S1.1941.00
4_E57_R1.1801.00
28_E31_H1.1481.00
32_R35_W1.1081.00
29_V33_W1.0901.00
36_W39_G1.0701.00
27_A30_C1.0451.00
34_S38_A1.0421.00
30_C33_W1.0321.00
11_D53_S1.0181.00
23_V27_A1.0101.00
53_S56_A1.0081.00
50_F53_S1.0011.00
23_V30_C0.9950.99
38_A42_L0.9720.99
21_G47_S0.9720.99
14_G49_L0.9670.99
30_C34_S0.9490.99
37_I40_T0.9230.99
4_E60_R0.9050.99
3_Y7_S0.8950.99
23_V44_L0.8930.99
25_F39_G0.8460.98
23_V32_R0.8320.98
21_G27_A0.8290.98
11_D54_A0.8160.98
35_W39_G0.8030.98
50_F54_A0.7970.98
15_S51_G0.7910.97
18_F50_F0.7820.97
13_L17_C0.7740.97
4_E8_T0.7480.96
7_S57_R0.7320.96
11_D50_F0.7300.96
22_S25_F0.7280.96
10_N49_L0.7210.96
3_Y11_D0.7020.95
5_A8_T0.6950.95
14_G53_S0.6940.95
11_D15_S0.6890.94
53_S57_R0.6870.94
4_E7_S0.6850.94
33_W36_W0.6770.94
13_L49_L0.6730.94
39_G50_F0.6590.93
34_S37_I0.6490.92
48_V52_I0.6480.92
21_G24_L0.6380.92
13_L16_I0.6290.91
52_I55_V0.6260.91
5_A9_A0.6180.90
15_S54_A0.6170.90
18_F41_W0.6110.90
5_A48_V0.6070.90
49_L52_I0.6010.89
12_A50_F0.5920.88
27_A31_H0.5910.88
21_G43_F0.5790.87
5_A17_C0.5610.86
11_D14_G0.5590.85
21_G39_G0.5520.85
12_A60_R0.5490.84
7_S10_N0.5380.83
43_F47_S0.5350.83
29_V38_A0.5190.81
9_A48_V0.5150.80
54_A57_R0.5080.80
23_V28_E0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wxwA 1 0.9355 7.5 0.839 Contact Map
1v54A 1 0.629 4.4 0.855 Contact Map
3wfdB 1 0.4839 4 0.858 Contact Map
4x5mA 2 0.871 2.5 0.873 Contact Map
1eysM 1 1 2.5 0.873 Contact Map
1fftA 1 1 2.4 0.873 Contact Map
2wjnM 1 1 2.4 0.874 Contact Map
1eysL 1 1 2.3 0.874 Contact Map
4p79A 1 1 2.3 0.875 Contact Map
1vryA 1 0.871 2.1 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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