GREMLIN Database
DUF4304 - Domain of unknown function (DUF4304)
PFAM: PF14137 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 117 (114)
Sequences: 3256 (2835)
Seq/√Len: 265.5
META: 0.911

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_E74_R3.4151.00
19_R26_Q3.4031.00
44_T89_W3.3631.00
31_Q46_N3.3181.00
16_T29_N3.1561.00
107_E111_E2.3621.00
48_G71_C2.2831.00
46_N76_R2.2151.00
29_N46_N2.1961.00
3_P7_P2.0451.00
47_L113_A1.9351.00
50_Y55_A1.9301.00
20_E52_P1.9071.00
31_Q76_R1.8291.00
6_K12_K1.7851.00
73_I116_W1.6711.00
44_T87_D1.6441.00
106_A110_E1.5961.00
32_K41_G1.5851.00
44_T76_R1.5501.00
42_S91_D1.5491.00
10_F26_Q1.4561.00
17_F30_F1.4471.00
4_L8_L1.4391.00
21_S26_Q1.4231.00
96_T101_L1.4101.00
54_L72_H1.4061.00
99_E103_E1.3761.00
27_V71_C1.3601.00
77_L113_A1.3501.00
33_S36_N1.3391.00
18_Y66_P1.3261.00
5_L28_I1.3251.00
24_L51_S1.3241.00
90_W108_A1.2681.00
2_A12_K1.2671.00
27_V48_G1.2601.00
102_A106_A1.2601.00
29_N68_E1.2271.00
57_W60_K1.2221.00
35_W42_S1.1971.00
71_C74_R1.1971.00
43_F105_V1.1831.00
15_R32_K1.1641.00
78_G88_K1.1511.00
33_S42_S1.1471.00
78_G87_D1.1451.00
3_P43_F1.1371.00
13_S65_K1.1301.00
18_Y25_I1.1231.00
28_I109_L1.0981.00
30_F43_F1.0821.00
8_L110_E1.0801.00
104_E108_A1.0671.00
44_T78_G1.0511.00
4_L7_P1.0491.00
67_K70_D1.0401.00
81_L108_A1.0171.00
110_E113_A1.0101.00
108_A112_Y1.0021.00
93_D96_T0.9651.00
45_V77_L0.9531.00
58_G62_P0.9321.00
2_A17_F0.9301.00
76_R87_D0.9261.00
28_I45_V0.9231.00
25_I52_P0.9171.00
40_G91_D0.9091.00
103_E107_E0.9081.00
44_T80_L0.8951.00
26_Q49_V0.8931.00
18_Y27_V0.8911.00
47_L77_L0.8901.00
21_S24_L0.8901.00
68_E71_C0.8791.00
13_S18_Y0.8781.00
36_N41_G0.8751.00
97_D100_E0.8731.00
63_P67_K0.8691.00
24_L49_V0.8611.00
66_P70_D0.8561.00
2_A6_K0.8481.00
10_F19_R0.8441.00
18_Y65_K0.8270.99
36_N40_G0.8190.99
32_K36_N0.8160.99
50_Y72_H0.8160.99
97_D101_L0.8060.99
101_L105_V0.8050.99
51_S72_H0.8000.99
34_R42_S0.7990.99
50_Y71_C0.7950.99
58_G61_P0.7930.99
89_W104_E0.7910.99
66_P71_C0.7870.99
12_K17_F0.7860.99
82_P112_Y0.7850.99
23_D53_E0.7780.99
100_E104_E0.7710.99
53_E56_E0.7610.99
109_L114_L0.7530.99
105_V108_A0.7470.99
51_S54_L0.7310.99
16_T27_V0.7310.99
85_E88_K0.7300.99
75_A79_S0.7180.98
33_S44_T0.7120.98
35_W40_G0.7000.98
78_G82_P0.6940.98
44_T90_W0.6900.98
77_L90_W0.6840.98
33_S39_D0.6720.98
4_L106_A0.6710.97
109_L113_A0.6690.97
2_A15_R0.6690.97
4_L110_E0.6650.97
81_L84_G0.6650.97
55_A65_K0.6590.97
52_P55_A0.6530.97
98_L102_A0.6420.97
37_T40_G0.6330.96
31_Q44_T0.6280.96
56_E61_P0.6250.96
99_E107_E0.6180.96
25_I55_A0.6160.96
47_L80_L0.6150.96
40_G93_D0.6140.96
107_E110_E0.6130.96
25_I50_Y0.6120.96
50_Y54_L0.6110.96
50_Y66_P0.6080.96
78_G81_L0.6070.96
59_G62_P0.6020.95
30_F45_V0.5990.95
83_G88_K0.5940.95
13_S17_F0.5920.95
61_P65_K0.5890.95
103_E110_E0.5870.95
81_L112_Y0.5840.94
94_D101_L0.5840.94
55_A72_H0.5820.94
13_S64_K0.5810.94
38_A41_G0.5740.94
36_N39_D0.5730.94
12_K15_R0.5720.94
79_S85_E0.5700.94
11_K20_E0.5640.93
17_F101_L0.5610.93
49_V73_I0.5600.93
44_T77_L0.5570.93
29_N76_R0.5480.92
113_A116_W0.5480.92
99_E110_E0.5460.92
32_K51_S0.5370.92
80_L112_Y0.5300.91
81_L85_E0.5260.91
88_K104_E0.5250.91
112_Y115_P0.5180.90
26_Q51_S0.5180.90
98_L101_L0.5160.90
35_W91_D0.5140.90
36_N42_S0.5130.90
24_L73_I0.5120.90
67_K71_C0.5100.89
57_W61_P0.5070.89
31_Q89_W0.5040.89
48_G54_L0.5040.89
52_P91_D0.5040.89
93_D101_L0.5040.89
78_G90_W0.5030.89
50_Y77_L0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ofkA 1 0.3333 16 0.876 Contact Map
1gm6A 1 0.2479 5.4 0.899 Contact Map
1y8cA 1 0.3333 4.4 0.903 Contact Map
3ui3A 2 0.5983 3.3 0.909 Contact Map
3dp7A 2 0.265 3.2 0.91 Contact Map
3h2bA 2 0.2735 3.1 0.911 Contact Map
4wxhA 2 0.2991 3.1 0.911 Contact Map
2a2pA 1 0.4103 3 0.911 Contact Map
4crwA 1 0.3333 2.8 0.913 Contact Map
4pv6C 3 0.3077 2.7 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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