GREMLIN Database
DUF4303 - Domain of unknown function (DUF4303)
PFAM: PF14136 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 155 (153)
Sequences: 1218 (1034)
Seq/√Len: 83.6
META: 0.795

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
42_E60_R4.7981.00
6_R118_E4.4821.00
20_T43_E3.5501.00
2_A114_E3.3491.00
116_D126_R3.1031.00
19_E68_Y2.7991.00
62_S65_E2.7971.00
113_K151_R2.7851.00
12_L39_A2.7291.00
40_N66_W2.5381.00
5_A9_F2.4481.00
107_A111_A2.3771.00
61_W130_V2.3021.00
113_K117_A1.9861.00
23_A66_W1.9581.00
17_P21_F1.9301.00
100_F104_L1.8681.00
115_L121_F1.8211.00
132_F149_A1.7881.00
11_E15_E1.7241.00
27_Y36_G1.6991.00
30_D138_D1.6691.00
28_T32_A1.6371.00
40_N67_P1.6361.00
86_R100_F1.6031.00
29_D34_T1.5751.00
22_Y42_E1.5611.00
106_E110_E1.5341.00
115_L118_E1.5221.00
125_E128_D1.4810.99
4_A76_F1.4510.99
140_D143_E1.4220.99
22_Y40_N1.4150.99
111_A115_L1.4060.99
116_D131_L1.3720.99
116_D122_G1.3690.99
135_V138_D1.3610.99
48_V52_Y1.3590.99
24_F37_P1.3420.99
34_T65_E1.3370.99
9_F37_P1.3320.99
52_Y56_D1.3040.98
122_G126_R1.3010.98
106_E113_K1.2870.98
81_E85_E1.2370.98
138_D143_E1.2310.98
16_H19_E1.2190.98
147_E151_R1.2190.98
115_L119_G1.2050.97
105_L109_V1.1890.97
28_T105_L1.1800.97
141_E145_E1.1790.97
103_L107_A1.1670.97
136_S141_E1.1580.97
19_E43_E1.1520.97
116_D124_G1.1470.96
93_D96_D1.1370.96
63_P134_S1.1310.96
2_A6_R1.1300.96
6_R115_L1.1250.96
29_D33_M1.1160.96
53_P56_D1.1030.96
134_S138_D1.1000.96
80_N84_R1.0780.95
135_V141_E1.0590.94
21_F41_T1.0580.94
69_E72_G1.0560.94
72_G75_L1.0350.94
32_A105_L1.0270.94
19_E67_P1.0220.93
22_Y60_R1.0220.93
62_S71_G1.0170.93
52_Y55_D1.0030.93
115_L120_L0.9790.92
55_D59_Y0.9760.92
19_E47_R0.9730.92
10_E14_E0.9710.91
134_S148_S0.9670.91
141_E144_L0.9590.91
120_L129_I0.9580.91
30_D64_A0.9570.91
86_R104_L0.9530.91
63_P66_W0.9420.90
108_M111_A0.9400.90
3_E6_R0.9390.90
109_V151_R0.9170.89
47_R50_A0.9150.89
40_N44_A0.9110.89
124_G129_I0.9050.88
53_P58_Y0.8930.88
80_N83_L0.8820.87
137_D140_D0.8820.87
23_A132_F0.8780.87
3_E7_A0.8770.87
5_A26_L0.8660.86
51_E54_E0.8630.86
86_R90_L0.8600.86
138_D142_E0.8600.86
78_E81_E0.8570.85
134_S137_D0.8560.85
28_T108_M0.8540.85
8_A24_F0.8530.85
116_D121_F0.8480.85
27_Y38_A0.8480.85
35_V108_M0.8470.85
34_T136_S0.8470.85
9_F13_R0.8450.85
23_A40_N0.8410.84
68_Y99_A0.8380.84
38_A64_A0.8280.83
9_F120_L0.8280.83
141_E148_S0.8260.83
27_Y37_P0.8220.83
38_A61_W0.8170.83
29_D136_S0.8150.82
22_Y44_A0.8080.82
6_R10_E0.8020.81
13_R122_G0.7960.81
136_S139_D0.7940.81
25_A38_A0.7890.80
9_F24_F0.7870.80
22_Y45_L0.7800.80
122_G125_E0.7780.79
21_F39_A0.7750.79
9_F25_A0.7750.79
110_E117_A0.7700.79
26_L35_V0.7690.79
27_Y64_A0.7640.78
22_Y43_E0.7590.78
126_R129_I0.7590.78
63_P104_L0.7560.77
25_A66_W0.7550.77
26_L108_M0.7490.77
27_Y69_E0.7420.76
134_S141_E0.7280.75
6_R119_G0.7220.74
76_F80_N0.7190.74
98_E106_E0.7150.73
16_H68_Y0.7140.73
25_A63_P0.7130.73
108_M112_L0.7090.73
23_A63_P0.6980.72
106_E151_R0.6890.71
82_L99_A0.6850.70
28_T31_D0.6850.70
35_V104_L0.6840.70
135_V139_D0.6820.70
124_G154_P0.6790.70
41_T108_M0.6710.69
150_K154_P0.6630.68
22_Y61_W0.6620.68
137_D142_E0.6570.67
50_A53_P0.6560.67
131_L134_S0.6530.67
79_V82_L0.6510.66
48_V51_E0.6510.66
138_D148_S0.6470.66
25_A110_E0.6470.66
44_A60_R0.6430.65
145_E148_S0.6420.65
5_A35_V0.6400.65
20_T42_E0.6350.64
69_E73_D0.6350.64
107_A110_E0.6330.64
78_E95_D0.6330.64
13_R116_D0.6310.64
71_G75_L0.6300.64
4_A79_V0.6290.64
18_D78_E0.6260.63
13_R110_E0.6220.63
14_E99_A0.6180.62
42_E46_E0.6170.62
39_A116_D0.6150.62
9_F115_L0.6100.61
23_A109_V0.6100.61
102_E142_E0.6070.61
40_N61_W0.6030.60
16_H21_F0.5980.60
132_F145_E0.5950.59
65_E139_D0.5930.59
33_M97_F0.5920.59
132_F148_S0.5910.59
138_D141_E0.5910.59
76_F82_L0.5900.59
3_E11_E0.5900.59
13_R24_F0.5900.59
26_L32_A0.5890.59
78_E117_A0.5890.59
25_A132_F0.5880.59
3_E135_V0.5870.58
46_E49_A0.5840.58
134_S145_E0.5750.57
44_A67_P0.5700.56
24_F121_F0.5700.56
8_A72_G0.5680.56
56_D59_Y0.5650.56
34_T64_A0.5630.55
24_F112_L0.5620.55
63_P137_D0.5600.55
140_D149_A0.5570.55
37_P76_F0.5550.54
18_D88_D0.5510.54
138_D145_E0.5490.53
82_L93_D0.5450.53
82_L85_E0.5420.53
133_V138_D0.5400.52
7_A75_L0.5400.52
88_D117_A0.5390.52
32_A135_V0.5380.52
65_E136_S0.5370.52
97_F100_F0.5370.52
27_Y136_S0.5340.51
134_S146_N0.5340.51
76_F79_V0.5320.51
138_D146_N0.5300.51
7_A14_E0.5250.50
36_G133_V0.5230.50
36_G69_E0.5230.50
55_D58_Y0.5200.50
124_G127_E0.5170.49
99_A117_A0.5160.49
5_A76_F0.5150.49
13_R119_G0.5120.49
29_D32_A0.5110.48
139_D143_E0.5050.48
87_P90_L0.5030.47
105_L133_V0.5020.47
79_V139_D0.5010.47
31_D101_R0.5000.47
95_D106_E0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2d8bA 1 0.8645 7.9 0.918 Contact Map
3dawB 1 0.8645 5.8 0.923 Contact Map
3oeqA 3 0.5742 3.7 0.93 Contact Map
4csoA 1 0.8839 3.6 0.93 Contact Map
3zxwB 1 0.271 3 0.933 Contact Map
5csmA 2 0.4 2.7 0.935 Contact Map
1vw42 1 0.3355 2.6 0.935 Contact Map
4bx8A 1 0.9548 2.5 0.936 Contact Map
1ew4A 1 0.6065 2.4 0.936 Contact Map
3j7y8 1 0.1613 2.4 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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