GREMLIN Database
DUF4302 - Domain of unknown function (DUF4302)
PFAM: PF14135 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 238 (234)
Sequences: 1296 (1133)
Seq/√Len: 74.1
META: 0.808

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
7_K15_E7.5881.00
33_M139_M4.2071.00
7_K11_E3.9851.00
17_L79_L3.7861.00
51_M59_V3.3601.00
61_M96_L3.1311.00
101_D108_G3.0371.00
78_R90_D2.7651.00
225_T230_T2.7371.00
75_S93_N2.7091.00
51_M61_M2.4151.00
35_Y113_G2.4041.00
20_Y119_I2.3601.00
17_L85_P2.3071.00
18_A22_D2.2961.00
50_L150_W2.1201.00
54_N58_R2.0681.00
11_E15_E2.0591.00
82_D133_K2.0551.00
36_Y46_G2.0491.00
109_E112_G2.0441.00
219_R233_E2.0321.00
120_L131_K2.0301.00
33_M51_M1.9711.00
127_T142_T1.9561.00
97_H115_F1.9451.00
27_A30_G1.9241.00
34_E219_R1.9001.00
216_T235_T1.8791.00
114_D132_G1.8731.00
225_T228_G1.8381.00
82_D86_V1.8151.00
153_Y157_V1.7331.00
214_T217_G1.7041.00
60_T74_T1.6921.00
131_K136_G1.6701.00
220_F234_F1.6631.00
59_V75_S1.6571.00
15_E19_E1.6381.00
192_I196_Y1.6231.00
151_E155_A1.6180.99
102_P110_G1.6180.99
33_M141_L1.6070.99
116_E133_K1.6020.99
23_L128_I1.5950.99
127_T140_V1.5950.99
8_S11_E1.5940.99
223_P230_T1.5910.99
32_K142_T1.5720.99
16_A20_Y1.5620.99
47_Y99_L1.5040.99
61_M95_Y1.5000.99
123_A128_I1.5000.99
62_A150_W1.4940.99
58_R76_S1.4860.99
130_L141_L1.4810.99
50_L144_A1.4500.99
129_V140_V1.4280.99
60_T72_T1.4130.99
76_S90_D1.4050.99
27_A143_K1.4040.99
189_T192_I1.3970.99
78_R88_S1.3950.98
34_E142_T1.3940.98
49_F99_L1.3920.98
200_E203_E1.3900.98
220_F233_E1.3680.98
42_Q221_Y1.3430.98
104_S107_D1.3360.98
35_Y117_F1.3230.98
76_S91_T1.2890.97
149_D152_E1.2890.97
16_A85_P1.2860.97
211_Y218_I1.2840.97
119_I130_L1.2680.97
52_K60_T1.2650.97
37_P45_G1.2600.97
122_S125_G1.2590.97
58_R74_T1.2550.97
81_A85_P1.2430.97
22_D26_S1.2410.97
32_K144_A1.2280.97
25_T55_D1.2230.97
49_F95_Y1.2090.96
112_G135_N1.2020.96
80_K90_D1.1970.96
86_V133_K1.1600.95
80_K88_S1.1380.95
212_I219_R1.1300.95
62_A72_T1.1270.94
186_D192_I1.1230.94
152_E155_A1.1140.94
190_R194_F1.1130.94
150_W153_Y1.1090.94
122_S126_D1.1090.94
20_Y85_P1.1070.94
146_E150_W1.0980.94
45_G64_D1.0900.93
90_D132_G1.0870.93
220_F223_P1.0790.93
187_S190_R1.0770.93
123_A126_D1.0770.93
21_K77_Y1.0520.92
102_P132_G1.0360.92
37_P135_N1.0340.92
37_P42_Q1.0320.91
50_L62_A1.0210.91
214_T219_R1.0100.91
65_F99_L1.0050.90
122_S129_V1.0010.90
156_K159_A1.0000.90
190_R196_Y1.0000.90
49_F96_L0.9950.90
187_S192_I0.9940.90
13_L81_A0.9930.90
75_S91_T0.9930.90
125_G128_I0.9880.90
207_V224_L0.9820.89
34_E48_T0.9790.89
97_H100_S0.9790.89
223_P231_I0.9740.89
84_G118_L0.9700.89
186_D189_T0.9650.88
200_E205_K0.9640.88
208_T211_Y0.9640.88
14_N18_A0.9630.88
131_K138_K0.9440.87
187_S191_T0.9400.87
122_S127_T0.9370.87
218_I234_F0.9300.87
113_G117_F0.9190.86
92_Y102_P0.9170.86
19_E22_D0.9140.86
68_S72_T0.9130.85
122_S128_I0.9130.85
75_S90_D0.9120.85
90_D102_P0.9100.85
55_D58_R0.9070.85
16_A19_E0.9040.85
120_L138_K0.9040.85
29_N145_T0.8970.84
90_D114_D0.8960.84
185_F192_I0.8960.84
88_S135_N0.8950.84
73_K95_Y0.8910.84
100_S134_K0.8890.84
178_G181_Y0.8880.84
148_E152_E0.8870.84
28_P146_E0.8840.84
129_V138_K0.8780.83
127_T143_K0.8750.83
23_L125_G0.8650.82
62_A154_L0.8630.82
42_Q135_N0.8560.82
118_L131_K0.8530.81
150_W155_A0.8490.81
63_S95_Y0.8400.80
181_Y226_I0.8360.80
156_K215_P0.8320.80
73_K94_E0.8270.79
99_L113_G0.8270.79
172_K177_G0.8240.79
36_Y221_Y0.8210.79
49_F111_L0.8180.79
10_A14_N0.8130.78
88_S116_E0.8090.78
24_L141_L0.8070.78
92_Y97_H0.8010.77
26_S143_K0.7910.76
21_K79_L0.7900.76
132_G135_N0.7900.76
207_V226_I0.7860.76
186_D190_R0.7830.75
80_K101_D0.7700.74
52_K125_G0.7700.74
11_E14_N0.7660.74
179_K182_E0.7640.74
26_S125_G0.7610.73
172_K178_G0.7600.73
83_Q118_L0.7570.73
67_D71_T0.7540.73
119_I122_S0.7530.73
145_T156_K0.7520.73
196_Y199_L0.7490.72
20_Y130_L0.7460.72
155_A159_A0.7430.72
23_L123_A0.7400.71
5_F9_P0.7390.71
153_Y159_A0.7380.71
176_I182_E0.7340.71
124_S127_T0.7320.70
170_Y173_R0.7240.70
124_S128_I0.7190.69
21_K25_T0.7190.69
107_D111_L0.7130.68
123_A129_V0.7070.68
23_L26_S0.7060.68
173_R182_E0.7050.68
59_V96_L0.7040.67
223_P232_Q0.7040.67
101_D110_G0.7030.67
100_S115_F0.7020.67
84_G133_K0.7020.67
146_E153_Y0.6990.67
71_T94_E0.6960.67
34_E212_I0.6940.66
227_G230_T0.6920.66
17_L21_K0.6890.66
126_D143_K0.6850.65
35_Y139_M0.6850.65
116_E134_K0.6840.65
120_L130_L0.6820.65
191_T195_T0.6800.65
85_P119_I0.6690.64
147_A151_E0.6620.63
113_G135_N0.6520.62
191_T194_F0.6500.61
181_Y186_D0.6500.61
126_D129_V0.6480.61
100_S135_N0.6470.61
120_L123_A0.6450.61
75_S89_F0.6450.61
80_K86_V0.6440.61
210_P221_Y0.6430.60
173_R180_T0.6410.60
130_L217_G0.6390.60
176_I179_K0.6370.60
75_S114_D0.6360.60
123_A143_K0.6350.60
24_L45_G0.6340.59
10_A13_L0.6330.59
46_G214_T0.6310.59
63_S97_H0.6310.59
201_D204_V0.6300.59
99_L212_I0.6300.59
13_L85_P0.6300.59
59_V145_T0.6280.59
59_V63_S0.6280.59
50_L157_V0.6270.59
25_T28_P0.6270.59
123_A127_T0.6270.59
172_K182_E0.6260.58
194_F197_N0.6210.58
192_I198_D0.6210.58
69_A72_T0.6200.58
82_D118_L0.6180.57
199_L202_G0.6170.57
82_D134_K0.6160.57
67_D70_T0.6140.57
220_F226_I0.6120.57
32_K48_T0.6080.56
200_E204_V0.6060.56
5_F12_R0.6060.56
213_Y220_F0.6050.56
116_E231_I0.6040.56
145_T149_D0.6030.56
152_E157_V0.6010.55
205_K224_L0.6010.55
190_R197_N0.6000.55
15_E18_A0.5980.55
13_L82_D0.5980.55
5_F8_S0.5970.55
124_S143_K0.5960.55
70_T73_K0.5930.54
175_T178_G0.5920.54
194_F199_L0.5910.54
63_S98_Y0.5910.54
42_Q137_N0.5900.54
145_T148_E0.5900.54
46_G93_N0.5880.54
185_F188_D0.5870.54
106_G111_L0.5870.54
75_S102_P0.5860.54
217_G234_F0.5860.54
47_Y111_L0.5860.54
152_E156_K0.5850.53
157_V215_P0.5850.53
171_F181_Y0.5840.53
45_G65_F0.5830.53
40_D112_G0.5830.53
27_A122_S0.5820.53
97_H141_L0.5810.53
20_Y128_I0.5800.53
69_A73_K0.5800.53
210_P222_E0.5780.53
19_E23_L0.5750.52
143_K150_W0.5740.52
31_W132_G0.5710.52
37_P137_N0.5690.51
209_T220_F0.5680.51
189_T193_T0.5640.51
24_L31_W0.5630.51
34_E140_V0.5630.51
118_L133_K0.5620.51
158_A161_A0.5610.50
23_L122_S0.5600.50
170_Y174_L0.5550.50
193_T211_Y0.5540.50
157_V161_A0.5540.50
29_N150_W0.5530.49
190_R193_T0.5530.49
109_E140_V0.5520.49
86_V118_L0.5500.49
20_Y81_A0.5500.49
50_L113_G0.5490.49
231_I234_F0.5480.49
148_E159_A0.5470.49
167_F188_D0.5430.48
154_L157_V0.5430.48
193_T208_T0.5420.48
222_E225_T0.5380.48
51_M141_L0.5350.47
97_H116_E0.5330.47
144_A148_E0.5330.47
146_E149_D0.5330.47
66_S70_T0.5330.47
20_Y23_L0.5330.47
102_P114_D0.5310.47
153_Y160_M0.5300.47
48_T64_D0.5290.46
32_K99_L0.5280.46
59_V136_G0.5280.46
36_Y212_I0.5270.46
14_N81_A0.5260.46
115_F133_K0.5230.46
86_V101_D0.5230.46
46_G141_L0.5230.46
99_L119_I0.5220.46
179_K185_F0.5200.45
153_Y161_A0.5190.45
80_K116_E0.5170.45
75_S96_L0.5170.45
110_G135_N0.5150.45
138_K143_K0.5150.45
6_D15_E0.5130.44
108_G137_N0.5120.44
171_F174_L0.5120.44
84_G134_K0.5120.44
152_E162_E0.5110.44
26_S29_N0.5110.44
219_R232_Q0.5090.44
52_K150_W0.5070.44
202_G205_K0.5070.44
190_R198_D0.5060.44
109_E134_K0.5040.43
197_N201_D0.5030.43
119_I123_A0.5030.43
82_D115_F0.5030.43
154_L159_A0.5020.43
78_R86_V0.5020.43
190_R195_T0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qniA 5 0.542 8.1 0.958 Contact Map
1sa3A 1 0.4286 7.1 0.959 Contact Map
4lh9A 4 0.1681 3.7 0.964 Contact Map
1q02A 1 0.2185 3.7 0.964 Contact Map
3h4pA 3 0.6933 3.5 0.964 Contact Map
4ujqH 1 0.1975 3.5 0.964 Contact Map
3n91A 1 0.5336 3.4 0.965 Contact Map
4r17F 1 0.7605 2.7 0.966 Contact Map
3j21P 1 0.1681 2.5 0.967 Contact Map
3nqkA 2 0.5294 2.2 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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