GREMLIN Database
DUF4297 - Domain of unknown function (DUF4297)
PFAM: PF14130 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 217 (212)
Sequences: 1003 (888)
Seq/√Len: 61.0
META: 0.754

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_A12_F5.5891.00
4_G8_A4.1211.00
27_H33_Y4.0391.00
11_R62_T3.4191.00
32_D45_V3.1881.00
19_A37_C3.1231.00
19_A43_I3.0801.00
8_A11_R2.9981.00
68_W107_F2.8531.00
9_R16_D2.7991.00
175_S182_H2.4731.00
175_S178_D2.4691.00
14_Y172_S2.4171.00
7_D11_R2.4131.00
69_T72_E2.3781.00
4_G7_D2.2961.00
4_G11_R2.2451.00
18_W22_K2.2441.00
212_E215_R2.2171.00
18_W108_V2.1981.00
137_K141_K2.1371.00
28_E193_K2.0691.00
40_H44_V2.0321.00
15_Q41_D2.0181.00
63_K66_G2.0091.00
178_D182_H1.9691.00
46_L55_I1.9131.00
41_D94_N1.8911.00
10_N179_H1.8901.00
25_E186_K1.8311.00
74_T143_I1.8241.00
207_R211_D1.8191.00
58_Y106_R1.8131.00
211_D215_R1.8111.00
15_Q19_A1.8101.00
87_I107_F1.7620.99
187_L206_Y1.7210.99
2_E94_N1.6640.99
210_I213_I1.6420.99
95_K105_L1.5880.99
181_T189_E1.5770.99
54_K103_S1.5560.99
71_K75_K1.5460.99
11_R16_D1.5070.98
184_I187_L1.4500.98
22_K26_L1.4400.98
72_E75_K1.4280.98
20_L23_L1.4190.97
32_D48_S1.4160.97
14_Y38_E1.4030.97
171_R174_L1.4010.97
18_W43_I1.3890.97
20_L213_I1.3890.97
162_L165_S1.3880.97
37_C43_I1.3740.97
14_Y60_V1.3590.97
178_D181_T1.3500.96
2_E40_H1.3490.96
140_L144_K1.3160.96
56_E103_S1.3100.96
56_E104_S1.2970.96
141_K145_K1.2930.96
41_D57_F1.2670.95
79_G84_P1.2540.95
37_C213_I1.2520.95
180_E184_I1.2350.94
15_Q38_E1.2260.94
118_K137_K1.1880.93
165_S169_F1.1860.93
26_L45_V1.1790.93
40_H57_F1.1620.92
26_L32_D1.1610.92
17_H179_H1.1560.92
57_F63_K1.1560.92
182_H185_G1.1540.92
135_L139_L1.1520.92
41_D44_V1.1420.91
9_R12_F1.1290.91
77_K80_K1.1240.91
2_E5_G1.1230.91
203_N208_A1.1110.90
141_K144_K1.1100.90
107_F113_F1.1100.90
34_L38_E1.1090.90
12_F15_Q1.0910.89
38_E115_L1.0870.89
6_S38_E1.0840.89
174_L190_F1.0830.89
79_G83_K1.0340.87
40_H98_F1.0260.86
6_S11_R1.0050.85
6_S14_Y0.9870.84
36_F40_H0.9870.84
22_K58_Y0.9820.84
11_R17_H0.9780.84
197_D200_S0.9690.83
11_R176_L0.9680.83
146_K149_K0.9650.83
211_D214_R0.9630.83
76_R89_G0.9600.82
67_K72_E0.9570.82
91_L94_N0.9550.82
57_F94_N0.9510.82
195_F198_S0.9500.82
131_C134_D0.9400.81
147_L150_E0.9330.81
89_G150_E0.9330.81
73_L107_F0.9290.80
68_W72_E0.9260.80
115_L169_F0.9210.80
77_K81_K0.9210.80
40_H86_S0.9200.80
69_T114_S0.9170.79
20_L32_D0.9150.79
42_D59_Q0.9120.79
184_I203_N0.9050.79
11_R37_C0.9010.78
148_K153_L0.8950.78
93_K97_D0.8900.77
3_K6_S0.8900.77
117_L120_L0.8890.77
116_K136_D0.8840.77
109_S113_F0.8820.77
191_L202_A0.8820.77
16_D38_E0.8810.77
66_G111_A0.8810.77
68_W109_S0.8790.77
104_S142_K0.8780.76
184_I189_E0.8760.76
18_W58_Y0.8620.75
106_R167_L0.8610.75
192_E203_N0.8560.75
63_K72_E0.8550.75
181_T186_K0.8530.74
9_R15_Q0.8530.74
86_S91_L0.8460.74
36_F94_N0.8440.74
5_G12_F0.8420.73
154_S157_D0.8390.73
15_Q42_D0.8380.73
17_H206_Y0.8380.73
187_L205_I0.8370.73
139_L142_K0.8340.73
41_D95_K0.8330.73
22_K91_L0.8240.72
36_F39_Y0.8160.71
60_V76_R0.8150.71
194_L198_S0.8090.70
200_S208_A0.8090.70
186_K213_I0.8050.70
199_K204_A0.8020.70
207_R212_E0.8020.70
57_F86_S0.7840.68
205_I213_I0.7710.67
147_L151_L0.7690.66
141_K146_K0.7660.66
6_S10_N0.7630.66
13_D18_W0.7590.65
11_R102_I0.7580.65
210_I215_R0.7570.65
37_C105_L0.7560.65
123_S126_S0.7540.65
38_E44_V0.7540.65
21_C183_L0.7530.65
18_W21_C0.7520.65
131_C138_E0.7520.65
32_D60_V0.7510.65
23_L182_H0.7510.65
39_Y57_F0.7450.64
15_Q40_H0.7450.64
145_K154_S0.7410.64
179_H183_L0.7370.63
62_T110_N0.7370.63
189_E203_N0.7340.63
14_Y62_T0.7330.63
37_C62_T0.7320.63
118_K124_L0.7300.62
203_N207_R0.7290.62
163_D166_K0.7280.62
132_L140_L0.7270.62
33_Y185_G0.7240.62
149_K152_S0.7230.62
92_L111_A0.7210.61
11_R40_H0.7150.61
5_G15_Q0.7140.61
107_F119_D0.7140.61
13_D214_R0.7130.61
43_I213_I0.7110.60
144_K153_L0.7110.60
118_K127_R0.7080.60
26_L35_V0.7030.60
196_P206_Y0.6980.59
109_S171_R0.6950.59
156_E160_E0.6950.59
63_K110_N0.6940.59
80_K152_S0.6940.59
49_E52_P0.6940.59
8_A16_D0.6920.58
202_A205_I0.6920.58
2_E57_F0.6920.58
179_H182_H0.6880.58
12_F176_L0.6850.58
60_V85_S0.6790.57
109_S201_N0.6780.57
38_E113_F0.6750.56
22_K45_V0.6750.56
145_K149_K0.6720.56
184_I188_A0.6720.56
192_E207_R0.6690.56
198_S207_R0.6670.56
5_G8_A0.6660.55
36_F46_L0.6640.55
69_T82_G0.6640.55
71_K74_T0.6630.55
42_D61_K0.6630.55
205_I212_E0.6620.55
78_K84_P0.6620.55
41_D46_L0.6580.55
45_V56_E0.6510.54
140_L143_I0.6480.53
199_K205_I0.6450.53
13_D210_I0.6450.53
54_K102_I0.6410.53
180_E187_L0.6380.52
170_I173_D0.6370.52
157_D160_E0.6350.52
198_S210_I0.6330.52
24_L187_L0.6320.52
7_D10_N0.6300.51
204_A208_A0.6280.51
125_D140_L0.6270.51
112_G169_F0.6260.51
198_S205_I0.6230.51
9_R17_H0.6220.50
57_F70_L0.6220.50
99_P148_K0.6200.50
86_S90_K0.6200.50
81_K84_P0.6200.50
32_D49_E0.6170.50
197_D205_I0.6150.50
43_I175_S0.6130.49
132_L167_L0.6110.49
172_S175_S0.6100.49
20_L105_L0.6030.48
38_E94_N0.5980.48
56_E106_R0.5970.48
113_F169_F0.5960.48
44_V55_I0.5920.47
66_G105_L0.5920.47
103_S154_S0.5920.47
90_K105_L0.5910.47
68_W87_I0.5880.47
55_I102_I0.5880.47
4_G10_N0.5840.46
31_D142_K0.5830.46
5_G62_T0.5800.46
195_F201_N0.5770.45
199_K202_A0.5740.45
136_D139_L0.5740.45
62_T94_N0.5700.45
93_K124_L0.5700.45
127_R156_E0.5690.44
32_D56_E0.5680.44
15_Q59_Q0.5660.44
204_A211_D0.5650.44
14_Y18_W0.5640.44
17_H20_L0.5630.44
50_S64_E0.5610.44
200_S203_N0.5600.43
8_A13_D0.5590.43
21_C43_I0.5590.43
13_D46_L0.5560.43
44_V63_K0.5560.43
23_L113_F0.5550.43
3_K7_D0.5550.43
91_L105_L0.5540.43
64_E67_K0.5510.42
35_V43_I0.5490.42
20_L33_Y0.5490.42
71_K144_K0.5480.42
196_P199_K0.5470.42
23_L90_K0.5470.42
88_L109_S0.5430.42
135_L149_K0.5420.41
11_R179_H0.5420.41
80_K83_K0.5410.41
71_K142_K0.5410.41
60_V71_K0.5410.41
29_D133_S0.5400.41
13_D17_H0.5390.41
99_P102_I0.5350.41
107_F160_E0.5310.40
77_K134_D0.5300.40
132_L147_L0.5300.40
19_A66_G0.5270.40
55_I162_L0.5270.40
79_G82_G0.5250.40
6_S17_H0.5230.39
26_L91_L0.5230.39
17_H92_L0.5220.39
40_H62_T0.5210.39
150_E163_D0.5160.39
33_Y150_E0.5150.39
10_N62_T0.5150.39
74_T200_S0.5120.38
195_F203_N0.5120.38
105_L115_L0.5120.38
150_E155_G0.5120.38
136_D141_K0.5100.38
203_N215_R0.5090.38
44_V57_F0.5070.38
36_F57_F0.5060.38
151_L166_K0.5060.38
66_G69_T0.5050.37
195_F208_A0.5030.37
35_V44_V0.5010.37
28_E125_D0.5000.37
41_D105_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wteA 2 0.8249 6.1 0.945 Contact Map
1ob8A 1 0.5622 5.2 0.947 Contact Map
1y88A 5 0.788 4.9 0.947 Contact Map
1nh2B 1 0.0876 3.5 0.951 Contact Map
1x4qA 1 0.3917 2.8 0.953 Contact Map
3p6zC 1 0 2.7 0.954 Contact Map
3wolA 2 0.6129 2.4 0.955 Contact Map
1nvpB 1 0.0783 2.3 0.956 Contact Map
2avaA 1 0.3548 2.2 0.956 Contact Map
2p7vA 1 0.3041 2.1 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0073 seconds.