GREMLIN Database
DUF4296 - Domain of unknown function (DUF4296)
PFAM: PF14129 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 87 (85)
Sequences: 8761 (7446)
Seq/√Len: 807.6
META: 0.936

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_T80_R2.9501.00
11_V76_K2.7161.00
16_D49_H2.7091.00
52_T55_Q2.0281.00
53_S57_D1.9811.00
12_D80_R1.8861.00
15_T84_E1.8361.00
20_A45_I1.8241.00
18_H74_Y1.8221.00
54_E58_K1.8221.00
11_V80_R1.8081.00
6_P9_K1.7181.00
66_H69_E1.6391.00
7_E69_E1.6221.00
3_N58_K1.6081.00
11_V15_T1.5671.00
46_F56_F1.5651.00
60_L70_L1.5111.00
15_T77_V1.4471.00
10_M59_S1.4331.00
78_I82_S1.4151.00
57_D61_K1.4091.00
7_E76_K1.3611.00
13_I45_I1.3481.00
19_L84_E1.3471.00
43_E47_K1.3341.00
76_K79_D1.3301.00
11_V77_V1.3301.00
4_L59_S1.2721.00
80_R84_E1.2711.00
11_V73_I1.2571.00
75_D79_D1.2541.00
5_I13_I1.2471.00
44_S47_K1.2451.00
71_E75_D1.2331.00
9_K12_D1.2281.00
7_E11_V1.2141.00
41_Y44_S1.1331.00
44_S48_K1.0871.00
46_F51_I1.0831.00
22_A26_T1.0781.00
13_I51_I1.0661.00
7_E72_K1.0591.00
5_I51_I1.0541.00
79_D83_K1.0411.00
12_D49_H1.0141.00
58_K61_K1.0081.00
80_R83_K1.0021.00
76_K80_R0.9981.00
51_I55_Q0.9701.00
51_I59_S0.9661.00
21_E42_Y0.9631.00
9_K49_H0.9531.00
16_D48_K0.9461.00
45_I49_H0.9441.00
12_D15_T0.9401.00
20_A41_Y0.9381.00
79_D82_S0.9371.00
8_D12_D0.9321.00
14_L18_H0.9021.00
61_K65_S0.8971.00
14_L77_V0.8961.00
46_F53_S0.8811.00
17_I42_Y0.8791.00
3_N59_S0.8701.00
18_H22_A0.8691.00
69_E72_K0.8671.00
70_L73_I0.8481.00
38_S42_Y0.8471.00
15_T81_L0.8251.00
43_E53_S0.8161.00
60_L64_A0.8021.00
59_S63_Y0.8011.00
70_L74_Y0.7981.00
15_T19_L0.7941.00
77_V81_L0.7931.00
75_D78_I0.7651.00
23_A27_N0.7641.00
34_D37_K0.7511.00
17_I21_E0.7471.00
7_E63_Y0.7471.00
40_A43_E0.7471.00
15_T18_H0.7431.00
40_A44_S0.7131.00
12_D16_D0.7091.00
59_S62_Y0.7021.00
9_K55_Q0.6931.00
62_Y66_H0.6931.00
39_I43_E0.6871.00
14_L74_Y0.6821.00
68_E72_K0.6691.00
27_N30_K0.6501.00
28_P31_L0.6491.00
74_Y78_I0.6491.00
7_E73_I0.6321.00
64_A70_L0.6291.00
23_A41_Y0.6251.00
73_I77_V0.6231.00
3_N6_P0.6221.00
3_N55_Q0.6211.00
26_T29_L0.6181.00
5_I59_S0.5981.00
61_K64_A0.5971.00
26_T30_K0.5831.00
71_E78_I0.5751.00
14_L17_I0.5651.00
19_L81_L0.5621.00
24_L38_S0.5621.00
67_P70_L0.5561.00
82_S85_K0.5551.00
59_S73_I0.5541.00
23_A26_T0.5531.00
10_M73_I0.5531.00
56_F60_L0.5481.00
20_A23_A0.5461.00
1_P62_Y0.5461.00
74_Y77_V0.5461.00
55_Q58_K0.5451.00
13_I49_H0.5431.00
29_L33_S0.5371.00
54_E57_D0.5361.00
33_S37_K0.5311.00
62_Y69_E0.5271.00
36_A39_I0.5251.00
68_E71_E0.5241.00
5_I55_Q0.5141.00
21_E24_L0.5031.00
29_L32_D0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1dq3A 1 1 11.9 0.849 Contact Map
4yn0B 1 0.931 11.7 0.85 Contact Map
3umhA 1 0.8736 11.2 0.851 Contact Map
3k66A 1 0.9655 7.4 0.863 Contact Map
3pmrA 2 0.908 6.6 0.866 Contact Map
4wjwA 2 0.5287 5.2 0.872 Contact Map
3tbgA 3 0.9425 4.3 0.877 Contact Map
3iyuX 3 0.8161 4.3 0.877 Contact Map
2dlaA 2 0.908 4.1 0.878 Contact Map
5ce7A 1 0.6322 4 0.879 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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